kfmrc@kau.edu.sa

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About Scientific Acheivemnets Team Members Education Contact
Vaccines and Immunotherapy Unit

The vaccines and immunotherapy unit aims to become a leading unit in the field of vital industry research by producing vaccines and viral and immunological treatments for priority diseases locally and globally by promoting and integrating basic, applied, and clinical research.

Also, translating the progress made in applied immunity research to produce and develop new, effective, and preventive immunological vaccines and treatments against cancer, and infectious and immune diseases, and to contribute to preparing a new generation of scientists and researchers specialized in these areas.



Research Areas
  • Infectious diseases
  • Allergies and chronic immune disorders
  • Organ transplantation
  • Cancer

+145

Publications

+8

Scientific Activities

+23

Patents

+6

Education and Training

+28

Partnerships & Consultations

+57

Students

Research Output

Scientific Acheivemnets


2023 Publications

1 Raman SNT, Zetner A, Hashem AM, Patel D, Wu J, Gravel C, Gao J, Zhang W, Pfeifle A, Tamming L, Parikh K, Cao J, Tam R, Safronetz D, Chen W, Johnston MJW, Wang L, Sauve S, Rosu-Myles M, Domselaar GV, Li X. Bivalent vaccines effectively protect mice against influenza A and respiratory syncytial viruses. Emerg Microbes Infect. 2023 Dec;12(1):2192821. doi: 10.1080/22221751.2023.2192821.


2 Wagstaff JM, Planelles-Herrero VJ, Sharov G, Alnami A, Kozielski F, Derivery E, Löwe J. Diverse cytomotive actins and tubulins share a polymerization switch mechanism conferring robust dynamics. Sci Adv. 2023 Mar 29;9(13):eadf3021. doi: 10.1126/sciadv.adf3021.


3 Alzahrani MM, Bamashmous S, Alkharobi H, Alghamdi A, Alharbi RH, Hassan AM, Darwish M, Bukhari A, Mahmoud AB, Alfaleh MA, Mirza AA, Abuzenadah AM, Abujamel TS, Hashem AM. Mouth rinses efficacy on salivary SARS-CoV-2 viral load: A randomized clinical trial. J Med Virol. 2023 Jan;95(1):e28412. doi: 10.1002/jmv.28412.


4 Shuaib M, Adroub S, Mourier T, Mfarrej S, Zhang H, Esau L, Alsomali A, Alofi FS, Ahmad AN, Shamsan A, Khogeer A, Hashem AM, Almontashiri NAM, Hala S, Pain A. Impact of the SARS-CoV-2 nucleocapsid 203K/204R mutations on the inflammatory immune response in COVID-19 severity. Genome Med. 2023 Jul 21;15(1):54. doi: 10.1186/s13073-023-01208-0


5 Alhabbab RY, Algaissi A, Mahmoud AB, Alkayyal AA, Al-Amri S, Alfaleh MA, Basabrain M, Alsubki RA, Almarshad IS, Alhudaithi AM, Gafari OAA, Alshamlan YA, Aldossari HM, Alsafi MM, Bukhari A, Bajhmom W, Memish ZA, Al Salem WS, Hashem AM. Middle East Respiratory Syndrome Coronavirus Infection Elicits Long-lasting Specific Antibody, T and B Cell Immune Responses in Recovered Individuals. Clin Infect Dis. 2023 Feb 8;76(3):e308-e318. doi: 10.1093/cid/ciac456.


6 Altorki TA, Abdulal RH, Suliman BA, Aljeraisi TM, Alsharef A, Abdulaal WH, Alfaleh MA, Algaissi AA, Alhabbab RY, Ozbak H, Eid HM, Almutawif YA, Li X, Al-Rabia MW, Zhang Q, Mahmoud AB, Mahallawi WH, Hashem AM. Robust memory humoral immune response to SARS-CoV-2 in the tonsils of adults and children. Front Immunol. 2023 Dec 11;14:1291534. doi: 10.3389/fimmu.2023.1291534.


7 Alfaleh MA, Alsulaiman RM, Almahboub SA, Nezamuldeen L, Zawawi A, Aljehani ND, Yasir M, Abdulaal RH, Alkhaldi R, Helal A, Alamri SS, Malki J, Alhabbab RY, Abujamel TS, Alhakamy NA, Alnami A, Algaissi A, Hassanain M, Hashem AM. ACE2-Fc and DPP4-Fc decoy receptors against SARS-CoV-2 and MERS-CoV variants: A quick therapeutic option for current and future coronaviruses outbreaks. Antibody Therapeutics, 2023;, tbad030, https://doi.org/10.1093/abt/tbad030


8 Harakeh S, Saber SH, Al-Raddadi R, Alamri T, Al-Jaouni S, Qari M, Qari Y, Haque S, Zawawi A, Ali SS, Elmageed ZYA, Mousa S. Novel curcumin nanoformulation induces apoptosis, and reduces migration and angiogenesis in liver cancer cells. Artif Cells Nanomed Biotechnol. 2023 Dec;51(1):361-370. doi: 10.1080/21691401.2023.2238756.


9 Ahmed MM, Fatima F, Alnami A, Alsenaidy M, Aodah AH, Aldawsari MF, Almutairy B, Anwer MK, Jafar M. Design and Characterization of Baricitinib Incorporated PLA 3D Printed Pills by Fused Deposition Modeling: An Oral Pill for Treating Alopecia Areata. Polymers (Basel). 2023 Apr 8;15(8):1825. doi: 10.3390/polym15081825.


10 Yacoub HA, Mahmoud MM, Al-Hejin AM, Abujamel TS, Tabrez S, Abd-Elmaksoud S. Effect of Nk-lysin peptides on bacterial growth, MIC, antimicrobial resistance, and viral activities. Anim Biotechnol. 2023 Dec 15:1-19. doi: 10.1080/10495398.2023.2290520.


11 Mahmoud MM, Al-Hejin AM, Abujamel TS, Ghetas AM, Yacoub HA. Chicken β-defensin-1 peptide as a candidate anticoccidial agent in broiler chickens. Anim Biotechnol. 2023 Dec;34(7):3108-3125. doi: 10.1080/10495398.2022.2136677.


12 Alfaleh MA, Razeeth Shait Mohammed M, Hashem AM, Abujamel TS, Alhakamy NA, Imran Khan M. Extracellular matrix detached cancer cells resist oxidative stress by increasing histone demethylase KDM6 activity. Saudi J Biol Sci. 2024 Jan;31(1):103871. doi: 10.1016/j.sjbs.2023.103871.


13 Abdulal RH, Khan MY, Aljehani ND, Fallata ZI, AlHarbi RH, Alsulaiman RM, Ghazal EA, Basabrain M, Sanki MA, Ganash M, Qadri I, Abdulaal WH, Alrabia MW, Hassanain M, Alfaleh MA, Raman SNT, Tamming L, Altorki T, Abujamel TS, Li X, Algaissi A, Alhabbab RY, Hashem AM. A Modified Recombinant DNA-Based SARS-CoV-2 Vaccine Expressing Stabilized Uncleavable Spike Protein Elicits Humoral and Cellular Immunity against Various SARS-CoV-2 Variants of Concern. Transbound Emerg Dis. 2023, Article ID 5279979, 11 pages.


14 Chauhan M, Garg V, Zia G, Dutt R, Alghamdi BS, Zawawi A, Ashraf GM, Farhana A. Effect of Extraction Methods on the Antioxidant Potential and Cytotoxicity of the Combined Ethanolic Extracts of Daucus carota L., Beta vulgaris L., Phyllanthus emblica L. and Lycopersicon esculentum against Gastric Adenocarcinoma Cells. Molecules. 2023 Sep 13;28(18):6589. doi: 10.3390/molecules28186589.


15 Cui TM, Altaf M, Aldarhami A, Bazaid AS, Saeedi NH, Alkayyal AA, Alshabrmi FM, Ali F, Aladhadh M, Khan MY, Alsaiari AA, Ma YR. Dihydropyrimidone Derivatives as Thymidine Phosphorylase Inhibitors: Inhibition Kinetics, Cytotoxicity, and Molecular Docking. Molecules. 2023 Apr 21;28(8):3634. doi: 10.3390/molecules28083634.


16 Mueed A, Shibli S, Al-Quwaie DA, Ashkan MF, Alharbi M, Alanazi H, Binothman N, Aljadani M, Majrashi KA, Huwaikem M, Abourehab MAS, Korma SA, El-Saadony MT. Extraction, characterization of polyphenols from certain medicinal plants and evaluation of their antioxidant, antitumor, antidiabetic, antimicrobial properties, and potential use in human nutrition. Front Nutr. 2023 Jun 21;10:1125106. doi: 10.3389/fnut.2023.1125106.


17 Nezamuldeen L, Jafri MS. Protein-Protein Interaction Network Extraction Using Text Mining Methods Adds Insight into Autism Spectrum Disorder. Biology (Basel). 2023 Oct 18;12(10):1344. doi: 10.3390/biology12101344.


18 Alhabbab RY. Economical and Easily Obtainable Tools to Manually Develop Lateral Flow Immunoassay Strips. ACS Omega. 2023 Mar 1;8(10):9170-9178. doi: 10.1021/acsomega.2c07014.


19 Singh M, Agarwal V, Jindal D, Pancham P, Agarwal S, Mani S, Tiwari RK, Das K, Alghamdi BS, Abujamel TS, Ashraf GM, Jha SK. Recent Updates on Corticosteroid-Induced Neuropsychiatric Disorders and Theranostic Advancements through Gene Editing Tools. Diagnostics (Basel). 2023 Jan 17;13(3):337. doi: 10.3390/diagnostics13030337.


20 Bakar A, Shams S, Bibi N, Ullah A, Ahmad W, Jelani M, Muthaffar OY, Abdulkareem AA, Abujamel TS, Haque A, Naseer MI, Khan B. A Novel Homozygous Nonsense Variant in the DYM Underlies Dyggve-Melchior-Clausen Syndrome in Large Consanguineous Family. Genes (Basel). 2023 Feb 17;14(2):510. doi: 10.3390/genes14020510.


21 Alhhazmi AA, Almutawif YA, Mumena WA, Alhazmi SM, Abujamel TS, Alhusayni RM, Aloufi R, Al-Hejaili RR, Alhujaily R, Alrehaili LM, Alsaedy RA, Khoja RH, Ahmed W, Abdelmohsen MF, Mohammed-Saeid W. Identification of Gut Microbiota Profile Associated with Colorectal Cancer in Saudi Population. Cancers (Basel). 2023 Oct 17;15(20):5019. doi: 10.3390/cancers15205019.


22 Elfadil A, Alzahrani AM, Abdullah H, Alsamhan H, Abujamel TS, Ahmed HE, Jiman-Fatani A. Evaluation of the Antibacterial Activity of Quinoxaline Derivative Compound Against Methicillin-Resistant Staphylococcus aureus. Infect Drug Resist. 2023 Apr 18;16:2291-2296. doi: 10.2147/IDR.S401371.


23 Alsaady IM, Altwaim S, Gattan HS, Alghanmi M, Zawawi A, Ahmedah H, Wakid MH, Azhar EI. Prevalence of permethrin-resistant kdr mutation in head lice (Pediculus humanus capitis) from elementary school students in Jeddah, Saudi Arabia. PeerJ. 2023 Oct 25;11:e16273. doi: 10.7717/peerj.16273. PMID: 37901472; PMCID: PMC10612490.


24 Alamri SS, Alsaieedi A, Khouqeer Y, Afeef M, Alharbi S, Algaissi A, Alghanmi M, Altorki T, Zawawi A, Alfaleh MA, Hashem AM, Alhabbab R. The importance of combining serological testing with RT-PCR assays for efficient detection of COVID-19 and higher diagnostic accuracy. PeerJ. 2023 Apr 11;11:e15024. doi: 10.7717/peerj.15024.


25 Al-Numaani SA, Al-Nemari AT, El-Kafrawy SA, Hassan AM, Tolah AM, Alghanmi M, Zawawi A, Masri BE, Hindawi SI, Alandijany TA, Bajrai LH, Bukhari A, Mahmoud AB, Al Salem WS, Algaissi A, Charrel RN, Azhar EI, Hashem AM. Seroprevalence of Toscana and sandfly fever Sicilian viruses in humans and livestock animals from western Saudi Arabia. One Health. 2023 Jul 11;17:100601. doi: 10.1016/j.onehlt.2023.100601.


26 Binothman N, Aljadani M, Alghanem B, Refai MY, Rashid M, Al Tuwaijri A, Alsubhi NH, Alrefaei GI, Khan MY, Sonbul SN, Aljoud F, Alhayyani S, Abdulal RH, Ganash M, Hashem AM. Identification of novel interacts partners of ADAR1 enzyme mediating the oncogenic process in aggressive breast cancer. Sci Rep. 2023 May 23;13(1):8341. doi: 10.1038/s41598-023-35517-6.


27 Rafeeq MM, Habib AH, Nahhas AF, Binothman N, Aljadani M, Almulhim J, Sain ZM, Alam MZ, Alturki NA, Alam Q, Manish M, Singh RK. Targeting Kaposi's sarcoma associated herpesvirus encoded protease (ORF17) by a lysophosphatidic acid molecule for treating KSHV associated diseases. Front Cell Dev Biol. 2023 Jan 17;11:1060156. doi: 10.3389/fcell.2023.1060156.


28 Almuhayawi MS, Hassan EA, Almasaudi SB, Zabermawi NM, Azhar EI, Najjar AA, Alkuwaity K, Abujamel TS, Alamri TA, Harakeh S. Biodiesel Production through Rhodotorula toruloides Lipids and Utilization of De-Oiled Biomass for Congo Red Removal. Sustainability 2023, 15, 13412. https://doi.org/10.3390/su151813412


29 Almuhayawi MS, Hassan EA, Alkuwaity K, Abujamel TS, Mokhtar JA, Niyazi HA, Almasaudi SB, Alamri TA, Najjar AA, Zabermawi NM, Azhar EI, Makki RM, Niyazi HA, Harakeh S. Enzymatic-Based Hydrolysis of Digested Potato Peel Wastes by Amylase Producing Fungi to Improve Biogas Generation. Catalysts 2023, 13, 913. https://doi.org/10.3390/catal13050913


30 Abdulal RH, Malki JS, Ghazal E, Alsaieedi AA, Almahboub SA, Khan MY, Alsulaiman RM, Ghaith MM, Abujamel TS, Ganash M, Mahmoud AB, Alkayyal AA, Hashem AM. Construction of VSVΔ51M oncolytic virus expressing human interleukin-12. Front Mol Biosci. 2023 May 15;10:1190669. doi: 10.3389/fmolb.2023.1190669.


31 Wahid M, Mandal RK, Jawed A, Alsulimani A, Hashem AM, Harakeh S, Hussain A, Fagoonee S, Pellicano R, Haque S. Combined effect of ipilimumab and nivolumab improves oncology endpoints in metastatic melanoma patients. Biotechnol Genet Eng Rev. 2023 Jan 8:1-14. doi: 10.1080/02648725.2022.2147683.


32 Kaur H, Singh A, Kaur K, Kumar A, Attri S, Rashid F, Singh S, Bedi N, Tuli HS, Haque S, Alkuwaity K, Tashkandi HM, Harakeh S, Arora S. 4-methylthiobutyl isothiocyanate synergize the antiproliferative and pro-apoptotic effects of paclitaxel in human breast cancer cells. Biotechnol Genet Eng Rev. 2023 Jan 22:1-25. doi: 10.1080/02648725.2022.2162232.


33 Teklemariam AD, Al Hindi R, Qadri I, Alharbi MG, Hashem AM, Alrefaei AA, Basamad NA, Haque S, Alamri T, Harakeh S. Phage cocktails - an emerging approach for the control of bacterial infection with major emphasis on foodborne pathogens. Biotechnol Genet Eng Rev. 2023 Mar 17:1-29. doi: 10.1080/02648725.2023.2178870.


34 Al Eissa MM, Almsned F, AlQurashi R, Alsanosi SM, Alshanberi AM, Saleh N, Alsaieedi AA, Alkharji RR, Halawani AJ. Perceptions of Saudis Toward Participating in the COVID-19 Convalescent Plasma Clinical Trial. Cureus. 2023 Nov 16;15(11):e48879. doi: 10.7759/cureus.48879.


35 Abou El-Kassem LT, Hawas UW, F Ahmed E, Binothman N, Alghamdi RA. Induction of apoptosis by emestrin from the plant endophytic fungus Emericella nidulans ATCC 38163 in Huh-7 human hepatocellular carcinoma cells. Nat Prod Res. 2023 Nov-Dec;37(24):4244-4250. doi: 10.1080/14786419.2023.2176489.


36 Harakeh S, Saber SH, Alamri T, Al-Raddadi R, Al-Jaouni S, Tashkandi H, Qari M, Qari Y, Akefe IO, Elmageed ZYA, Haque S, Hashem AM, Albajri EE, Mousa S. Novel 3′-diindolylmethane nanoformulation induces apoptosis, and reduces migration and angiogenesis in liver cancer cells. J King Saud University-Science. 2023 Nov;35(8):102864. doi: 10.1016/j.jksus.2023.102864.


37 Altwaim SA, Alsaady I, Gattan HS, Alruhaili MH, Alghanmi M, Abdalal SA, Kamaludeen J, Barnawi A. 2023. Awareness of Neglected Tropical Diseases Among Medical and Health Sciences Students at King Abdulaziz University, Jeddah: A Cross-Sectional Study. Bahrain Medical Bulletin, 45(3).


38 Abdalal SA, Yukich J, Andrinopoulos K, Alghanmi M, Wakid MH, Zawawi A, Harakeh S, Altwaim SA, Gattan H, Baakdah F, Gaddoury MA, Niyazi HA, Mokhtar JA, Alruhaili MH, Alsaady I, Alhabbab R, Alfaleh M, Hashem AM, Alahmadey ZZ, Keating J. Livelihood activities, human mobility, and risk of malaria infection in elimination settings: a case-control study. Malar J. 2023 Feb 13;22(1):53. doi: 10.1186/s12936-023-04470-0.


39 Rabaan AA, AlSaihati H, Bukhamsin R, Bakhrebah MA, Nassar MS, Alsaleh AA, Alhashem YN, Bukhamseen AY, Al-Ruhimy K, Alotaibi M, Alsubki RA, Alahmed HE, Al-Abdulhadi S, Alhashem FA, Alqatari AA, Alsayyah A, Farahat RA, Abdulal RH, Al-Ahmed AH, Imran M, Mohapatra RK. Application of CRISPR/Cas9 Technology in Cancer Treatment: A Future Direction. Curr Oncol. 2023 Feb 6;30(2):1954-1976. doi: 10.3390/curroncol30020152.


40 Brek T, Alghamdi AK, Abujamel TS, Yasir M, Alattas EM, Hazazi MS, Al-Zahrani IA. Prevalence and molecular determinants of carbapenemase-producing Klebsiella pneumoniae isolated from Jazan, Saudi Arabia. J Infect Dev Ctries. 2023 Oct 31;17(10):1420-1429. doi: 10.3855/jidc.17662.


41 Al-Raddadi, Rajaa Mohammad, et al. "Immunological Response to Conventional COVID-19 Vaccines in a Cohort of Pakistani Healthy Recipients." Indian Journal of Pharmaceutical Sciences 85 (2023).


42 Alamri T, Harakeh S, Saber H, Akefe IO, Ali SS, Naseeb M, Alkuwaity K, Niyazi HA, Niyazi HA, Mokhtar JA, Rath M, Niedzwiecki A, Zgool T. "Protective and Therapeutic Potential of a Novel Phytobiological Formulation of Nutrients in the Treatment of Indomethacin-Induced Gastric Ulcer. Indian J Pharm Sci 2023:85(2) Spl Issue “103-111”.


43 Mohammad R, Tanwir AMd, Abdulrahman AS, Deepak K, Raj K, Keun WL, Alnami A. New SARS-CoV-2 Mpro Inhibitor by Ascorbic Acid: Design, Molecular docking, Lipinski’s Rule and ADMET Analysis. Coronaviruses. 2023; 4 () : e141123223563 . https://dx.doi.org/10.2174/0126667975266805231107110146


44 Chapter Immunotherapy and Cancer Stem Cells (Molecular Targets and Cancer Therapeutics) By Ravi Teja Chitturi Suryaprakash, Mohammad Ayman Abdulkarim Safi, Noufa Alonazi, Ahdab A. Alsaieedi, Omar Kujan


2022 Publications

1 Alfaleh MA, Zawawi A, Al-Amri SS, Hashem AM. David versus goliath: ACE2-Fc receptor traps as potential SARS-CoV-2 inhibitors. MAbs. 2022 Jan-Dec;14(1):2057832.


2 Awan ZA, AlGhamdi SA, Alhakamy NA, Okbazghi SZ, Alfaleh MA, Badr-Eldin SM, Aldawsari HM, Abourehab MAS, Asfour HZ, Zakai SA, Alrabia MW, Negm AA, El-Moselhy MA, Sharkawi SS, Rizg WY. Optimized 2-methoxyestradiol invasomes fortified with apamin: a promising approach for suppression of A549 lung cancer cells. Drug Deliv. 2022 Dec;29(1):1536-1548.


3 Alzahrani MM, Bamashmous S, Alkharobi H, Alghamdi A, Alharbi RH, Hassan AM, Darwish M, Bukhari A, Mahmoud AB, Alfaleh MA, Mirza AA, Abuzenadah AM, Abujamel TS, Hashem AM. Mouth rinses efficacy on salivary SARS-CoV-2 viral load: A randomized clinical trial. J Med Virol. 2023 Jan;95(1):e28412.


4 Alfaleh MA, Fahmy O, Al-Rabia MW, Abourehab MAS, Ahmed OAA, Fahmy UA, H Alsulimani H, Badr-Eldin SM, Aldawsari HM, Aldhabi BM, Alharbi AS, Alhakamy NA. Hybrid nanoparticulate system of Fluvastatin loaded phospholipid, alpha lipoic acid and melittin for the management of colon cancer. Sci Rep. 2022 Nov 14;12(1):19446.


5 Latif K, Ullah A, Shkodina AD, Boiko DI, Rafique Z, Alghamdi BS, Alfaleh MA, Ashraf GM. Drug reprofiling history and potential therapies against Parkinson's disease. Front Pharmacol. 2022 Oct 26;13:1028356. 10.3389/fphar.2022.1028356.


6 Alfaleh MA, Hashem AM, Abujamel TS, Alhakamy NA, Kalam MA, Riadi Y, Md S. Apigenin Loaded Lipoid-PLGA-TPGS Nanoparticles for Colon Cancer Therapy: Characterization, Sustained Release, Cytotoxicity, and Apoptosis Pathways. Polymers (Basel). 2022 Aug 30;14(17):3577.


7 Alhabbab RY, Algaissi A, Mahmoud AB, Alkayyal AA, Al-Amri S, Alfaleh MA, Basabrain M, Alsubki RA, Almarshad IS, Alhudaithi AM, Gafari OAA, Alshamlan YA, Aldossari HM, Alsafi MM, Bukhari A, Bajhmom W, Memish ZA, Alsalem W, Hashem AM. MERS-CoV infection elicits long-lasting specific antibody, T and B cell immune responses in recovered individuals. Clin Infect Dis. 2022 Jun 8:ciac456.


8 Alhabbab RY, Alfaleh MA, Alsulaiman RM, Alamri SS, Eyouni MS, ElAssouli MZ, Abuzenadah AM, Hashem AM. Amplifying Lateral Flow Assay Signals for Rapid Detection of COVID-19 Specific Antibodies. Glob Chall. 2022 May 11;6(7):2200008.


9 Alhakamy NA, Okbazghi SZ, A Alfaleh M, H Abdulaal W, Bakhaidar RB, Alselami MO, Zahrani MA, Alqarni HM, F Alghaith A, Alshehri S, Badr-Eldin SM, Aldawsari HM, Al-Hejaili OD, Aldhabi BM, Mahdi WA. Wasp venom peptide improves the proapoptotic activity of alendronate sodium in A549 lung cancer cells. PLoS One. 2022 Feb 24;17(2):e0264093.


10 Alhakamy NA, Badr-Eldin SM, Ahmed OAA, Aldawsari HM, Okbazghi SZ, Alfaleh MA, Abdulaal WH, Neamatallah T, Al-Hejaili OD, Fahmy UA. Green Nanoemulsion Stabilized by In Situ Self-Assembled Natural Oil/Native Cyclodextrin Complexes: An Eco-Friendly Approach for Enhancing Anticancer Activity of Costunolide against Lung Cancer Cells. Pharmaceutics. 2022 Jan 19;14(2):227.


11 Iqubal A, Iqubal MK, Sharma S, Wasim M, Alfaleh MA, Md S, Baboota S, Ali J, Haque SE. Pathogenic mechanisms and therapeutic promise of phytochemicals and nanocarriers based drug delivery against radiotherapy-induced neurotoxic manifestations. Drug Deliv. 2022 Dec;29(1):1492-1511


12 El-Telbany M, Mohamed AA, Yahya G, Abdelghafar A, Abdel-Halim MS, Saber S, Alfaleh MA, Mohamed AH, Abdelrahman F, Fathey HA, Ali GH, Abdel-Haleem M. Combination of Meropenem and Zinc Oxide Nanoparticles; Antimicrobial Synergism, Exaggerated Antibiofilm Activity, and Efficient Therapeutic Strategy against Bacterial Keratitis. Antibiotics (Basel). 2022 Oct 7;11(10):1374.


13 Al-Rabia MW, Alfaleh MA, Asfour HZ, Alharbi WS, El-Moselhy MA, Alhakamy NA, Fahmy UA, Ahmed OAA, Fahmy O, Rashad OM, Alamoudi AJ, Abdel-Naim AB. 2-Methoxyestradiol TPGS Micelles Attenuate Cyclosporine A-Induced Nephrotoxicity in Rats through Inhibition of TGF-β1 and p-ERK1/2 Axis. Antioxidants (Basel). 2022 Jul 30;11(8):1499.


14 Alhabbab RY. Lateral Flow Immunoassays for Detecting Viral Infectious Antigens and Antibodies. Micromachines (Basel). 2022 Nov 3;13(11):1901.


15 Tamming LA, Duque D, Tran A, Zhang W, Pfeifle A, Laryea E, Wu J, Raman SNT, Gravel C, Russell MS, Hashem AM, Alsulaiman RM, Alhabbab RY, Gao J, Safronetz D, Cao J, Wang L, Chen W, Johnston MJW, Sauve S, Rosu-Myles M, Li X. DNA Based Vaccine Expressing SARS-CoV-2 Spike-CD40L Fusion Protein Confers Protection Against Challenge in a Syrian Hamster Model. Front Immunol. 2022 Jan 12;12:785349.


16 Ghozy S, El-Qushayri AE, Varney J, Kacimi SEO, Bahbah EI, Morra ME, Shah J, Kallmes KM, Abbas AS, Elfil M, Alghamdi BS, Ashraf G, Alhabbab R, Dmytriw AA. The prognostic value of neutrophil-to-lymphocyte ratio in patients with traumatic brain injury: A systematic review. Front Neurol. 2022 Oct 24;13:1021877.


17 Jabir NR, Firoz CK, Zughaibi TA, Alsaadi MA, Abuzenadah AM, Al-Asmari AI, Alsaieedi A, Ahmed BA, Ramu AK, Tabrez S. A literature perspective on the pharmacological applications of yohimbine. Ann Med. 2022 Dec;54(1):2861-2875.


18 Muhammad N, Usmani D, Tarique M, Naz H, Ashraf M, Raliya R, Tabrez S, Zughaibi TA, Alsaieedi A, Hakeem IJ, Suhail M. The Role of Natural Products and Their Multitargeted Approach to Treat Solid Cancer. Cells. 2022 Jul 15;11(14):2209.


19 Shah UJ, Alsulimani A, Ahmad F, Mathkor DM, Alsaieedi A, Harakeh S, Nasiruddin M, Haque S. Bioplatforms in liquid biopsy: advances in the techniques for isolation, characterization and clinical applications. Biotechnol Genet Eng Rev. 2022 Aug 13:1-45.


20 Haque S, Singh R, Pal DB, Harakeh S, Alghanmi M, Teklemariam AD, Abujamel TS, Srivastava N, Gupta VK. Recent Update on anaerobic digestion of paddy straw for biogas production: Advancement, limitation and recommendations. Environ Res. 2022 Dec;215(Pt 2):114292.


21 Kaleem M, Dalhat MH, Azmi L, Asar TO, Ahmad W, Alghanmi M, Almostadi A, Zughaibi TA, Tabrez S. An Insight into Molecular Targets of Breast Cancer Brain Metastasis. Int J Mol Sci. 2022 Oct 2;23(19):11687.


22 Naz R, Khan A, Alghamdi BS, Ashraf GM, Alghanmi M, Ahmad A, Bashir SS, Haq QMR. An Insight into Animal Glutamate Receptors Homolog of Arabidopsis thaliana and Their Potential Applications-A Review. Plants (Basel). 2022 Sep 30;11(19):2580.


23 Alsafi RT, Minshawi F, Alshareef A, Althobiany E, Alqurashi A, Zawawi A, Qasem A, Halawani AJ, Almatrafi M, Alwafi H, Samannodi M, Salawati E, Assaggaf HM. Haematological, Biochemical, and Inflammatory Biomarkers of COVID-19 Patients Hospitalized in Critical Unit: A Retrospective Study. Cureus. 2022 Mar 31;14(3):e23691.


24 Zughaibi TA, Mirza AA, Suhail M, Jabir NR, Zaidi SK, Wasi S, Zawawi A, Tabrez S. Evaluation of anticancer potential of biogenic copper oxide nanoparticles (CuO NPs) against breast cancer. Journal of Nanomaterials, 2022.5326355


25 Upadhayay S, Mehan S, Prajapati A, Sethi P, Suri M, Zawawi A, Almashjary MN, Tabrez S. Nrf2/HO-1 Signaling Stimulation through Acetyl-11-Keto-Beta-Boswellic Acid (AKBA) Provides Neuroprotection in Ethidium Bromide-Induced Experimental Model of Multiple Sclerosis. Genes (Basel). 2022 Jul 25;13(8):1324.


26 "Thabit AK, Eljaaly K, Zawawi A, Ibrahim TS, Eissa AG, Elbaramawi SS, Hegazy WAH, Elfaky MA. Muting Bacterial Communication: Evaluation of Prazosin Anti-Quorum Sensing Activities against Gram-Negative Bacteria Pseudomonas aeruginosa, Proteus mirabilis, and Serratia marcescens. Biology (Basel). 2022 Sep 13;11(9):1349. "


27 Thabit AK, Eljaaly K, Zawawi A, Ibrahim TS, Eissa AG, Elbaramawi SS, Hegazy WAH, Elfaky MA. Silencing of Salmonella typhimurium Pathogenesis: Atenolol Acquires Efficient Anti-Virulence Activities. Microorganisms. 2022 Oct 6;10(10):1976.


28 Elfaky MA, Thabit AK, Eljaaly K, Zawawi A, Abdelkhalek AS, Almalki AJ, Ibrahim TS, Hegazy WAH. Controlling of Bacterial Virulence: Evaluation of Anti-Virulence Activities of Prazosin against Salmonella enterica. Antibiotics (Basel). 2022 Nov 9;11(11):1585.


29 "Mahmoud MM, Al-Hejin AM, Abujamel TS, Ghetas AM, Yacoub HA. Chicken β-defensin-1 peptide as a candidate anticoccidial agent in broiler chickens. Anim Biotechnol. 2022 Oct 30:1-18. "


30 Mahmoud MM, Alenezi M, Al-Hejin AM, Abujamel TS, Aljoud F, Noorwali A, Awad IA, Alkhaled M, Yacoub HA. Anticancer activity of chicken cathelicidin peptides against different types of cancer. Mol Biol Rep. 2022 Jun;49(6):4321-4339.


31 Iftikhar N, Saleem A, Akhtar MF, Abbas G, Shah S, Bibi S, Ashraf GM, Alghamdi BS, Abujamel TS. In Vitro and In Vivo Anti-Arthritic Potential of Caralluma tuberculata N. E. Brown. and Its Chemical Characterization. Molecules. 2022 Sep 26;27(19):6323.


32 Haque S, Faidah H, Ashgar SS, Abujamel TS, Mokhtar JA, Almuhayawi MS, Harakeh S, Singh R, Srivastava N, Gupta VK. Green Synthesis of Zn(OH)2/ZnO-Based Bionanocomposite using Pomegranate Peels and Its Application in the Degradation of Bacterial Biofilm. Nanomaterials (Basel). 2022 Oct 3;12(19):3458.


33 Teklemariam AD, Hashem AM, Saber SH, Almuhayawi MS, Haque S, Abujamel TS, Harakeh S. Bacterial co-infections and antimicrobial resistance associated with the Coronavirus Disease 2019 infection. Biotechnol Genet Eng Rev. 2022 Sep 19:1-22.


34 Srivastava N, Singh R, Kushwaha D, Mokhtar JA, Abujamel TS, Harakeh S, Haque S, Srivastava M, Mishra PK, Gupta VK. Improved biohydrogen production via graphene oxide supported granular system based on algal hydrolyzate, secondary sewage sludge and bacterial consortia. J Biotechnol. 2022 Nov 10;358:41-45.


35 Zein HS, Abou-Samra E, Scur M, Gutsol A, Hall CW, Dasgupta B, Gharibeh L, Abujamel T, Medina-Luna D, Gamage GS, Pelino TJ, Nemer M, Rahim MMA, Steinle A, Parsons BD, Makrigiannis AP. Clr-f expression regulates kidney immune and metabolic homeostasis. Sci Rep. 2022 Mar 22;12(1):4834.


36 Abujamel TS, Al-Otaibi NM, Abuaish S, AlHarbi RH, Assas MB, Alzahrani SA, Alotaibi SM, El-Ansary A, Aabed K. Different Alterations in Gut Microbiota between Bifidobacterium longum and Fecal Microbiota Transplantation Treatments in Propionic Acid Rat Model of Autism. Nutrients. 2022 Jan 30;14(3):608.


37 Abuaish S, Al-Otaibi NM, Aabed K, Abujamel TS, Alzahrani SA, Alotaibi SM, Bhat RS, Arzoo S, Algahtani N, Moubayed NM, El-Ansary A. The Efficacy of Fecal Transplantation and Bifidobacterium Supplementation in Ameliorating Propionic Acid-Induced Behavioral and Biochemical Autistic Features in Juvenile Male Rats. J Mol Neurosci. 2022 Feb;72(2):372-381.


38 Alamri T, Alkhaldy AA, Gauthaman K, Pushparaj PN, Moulay M, Mirza AA, Azhar EI, Barnawi S, Papadopoulou G, Karamitros T, Abujamel TS, Harakeh S. Growth factors in relation to obesity, food habits, and microbiota among healthy Saudis: preliminary results. Eur Rev Med Pharmacol Sci. 2022 Dec;26(24):9311-9326.


39 Abujamel T S. Understanding the Mechanisms of Bacterial Antimicrobial Resistance within Biofilms. Int j pharm phytopharm res. 2022;12(1):17-24.


40 Arab WT, Susapto HH, Alhattab D, Hauser CAE. Peptide nanogels as a scaffold for fabricating dermal grafts and 3D vascularized skin models. J Tissue Eng. 2022 Jul 29;13:20417314221111868.


41 Abdeltawab SS, Abu Haimed TS, Bahammam HA, Arab WT, Abou Neel EA, Bahammam LA. Biocompatibility and Antibacterial Action of Salvadora persica Extract as Intracanal Medication (In Vitro and Ex Vivo Experiment). Materials (Basel). 2022 Feb 12;15(4):1373.


42 Kumar P, Gupta A, Mahato DK, Pandhi S, Pandey AK, Kargwal R, Mishra S, Suhag R, Sharma N, Saurabh V, Paul V, Kumar M, Selvakumar R, Gamlath S, Kamle M, Enshasy HAE, Mokhtar JA, Harakeh S. Aflatoxins in Cereals and Cereal-Based Products: Occurrence, Toxicity, Impact on Human Health, and Their Detoxification and Management Strategies. Toxins (Basel). 2022 Oct 6;14(10):687.


43 Shah S, Khan A, Shahzad M, Mokhtar JA, Harakeh S, Kibria Z, Mehr A, Bano B, Ali A, Yousafzai YM. Determinants of Response at 2 Months of Treatment in a Cohort of Pakistani Patients with Pulmonary Tuberculosis. Antibiotics (Basel). 2022 Sep 26;11(10):1307.


44 Babar M, Fatima M, Nawaz A, Bashir MA, Khan WA, Khan SA, Sneharani AH, Mokhtar JA, Abdalal S, Harakeh S, Essa M. Deficiency of vitamin-D in children with infection of urinary tract: Cross-sectional study. Journal of King Saud University - Science. 34 (7). 2022. 102229.


45 Radhwi OO, Jan H, Waheeb A, Alamri SS, Alahwal HM, Denetiu I, Almanzlawey A, Al-Marzouki AF, Almohammadi AT, Bahashwan SM, Barefah AS, Qari MH, Abuzenadah AM, Hashem AM. Immunogenicity of The BNT162b2 COVID-19 mRNA and ChAdOx1 nCoV-19 Vaccines in Patients with Hemoglobinopathies. Vaccines. 2022; 10(2):151.


46 Mourier T, Shuaib M, Hala S, Mfarrej S, Alofi F, Naeem R, Alsomali A, Jorgensen D, Subudhi AK, Ben Rached F, Guan Q, Salunke RP, Ooi A, Esau L, Douvropoulou O, Nugmanova R, Perumal S, Zhang H, Rajan I, Al-Omari A, Salih S, Shamsan A, Al Mutair A, Taha J, Alahmadi A, Khotani N, Alhamss A, Mahmoud A, Alquthami K, Dageeg A, Khogeer A, Hashem AM, Moraga P, Volz E, Almontashiri N, Pain A. SARS-CoV-2 genomes from Saudi Arabia implicate nucleocapsid mutations in host response and increased viral load. Nat Commun. 2022 Feb 1;13(1):601.


47 Barefah AS, Radhwi OO, Alamri SS, Alahwal HM, Denetiu I, Almohammadi AT, Bahashwan SM, Qari MH, Algaissi A, Alamer E, Alhazmi A, Abuzenadah AM, Nasraldeen WH, Alzahrani SH, Hashem AM. Low clinical utility of testing for anti-platelet factor 4 in asymptomatic individuals after ChAdOx1 nCoV-19 vaccine. Int J Lab Hematol. 2022 Apr;44(2):424-429.


48 Alenazi MW, Algaisi A, Zowawi HM, Aldibasi O, Hashem AM, Khalaf Alharbi N. Seroprevalence of COVID-19 in Riyadh City during the early increase of COVID-19 infections in Saudi Arabia, June 2020. Saudi J Biol Sci. 2022 Apr 22:103282.


49 Khan W, Ahmad W, Hashem AM, Zakai S, Haque S, Malik MFA, Harakeh S, Haq F. Genomic Relevance of FGFR2 on the Prognosis of HCV-Induced Hepatocellular Carcinoma Patients. Journal of Clinical Medicine. 2022; 11(11):3093.


50 Muralidharan A, Gravel C, Harris G, Hashem AM, Zhang W, Safronetz D, Van Domselaar G, Krammer F, Sauve S, Rosu-Myles M, Wang L, Chen W, Li X. Universal antibody targeting the highly conserved fusion peptide provides cross-protection in mice. Hum Vaccin Immunother. 2022 Jun 20:2083428.


51 Alharbi NK, Al-Tawfiq JA, Alwehaibe A, Alenazi MW, Almasoud A, Algaisi A, Alhumaydhi FA, Hashem AM, Bosaeed M, Alsagaby SA. Persistence of Anti-SARS-CoV-2 Spike IgG Antibodies Following COVID-19 Vaccines. Infect Drug Resist. 2022 Jul 29;15:4127-4136.


52 Atiya A, Alhumaydhi FA, Sharaf SE, Al Abdulmonem W, Elasbali AM, Al Enazi MM, Shamsi A, Jawaid T, Alghamdi BS, Hashem AM, Ashraf GM, Shahwan M. Identification of 11-Hydroxytephrosin and Torosaflavone A as Potential Inhibitors of 3-Phosphoinositide-Dependent Protein Kinase 1 (PDPK1): Toward Anticancer Drug Discovery. Biology (Basel). 2022 Aug 18;11(8):1230.


53 Alharbi NK, Aljamaan F, Aljami HA, Alenazi MW, Albalawi H, Almasoud A, Alharthi FJ, Azhar EI, Barhoumi T, Bosaeed M, Gilbert SC, Hashem AM. Immunogenicity of High-Dose MVA-Based MERS Vaccine Candidate in Mice and Camels. Vaccines (Basel). 2022 Aug 17;10(8):1330.


54 Tarique M, Suhail M, Naz H, Muhammad N, Tabrez S, Zughaibi TA, Abuzenadah AM, Hashem AM, Shankar H, Saini C, Sharma A. Where do T cell subsets stand in SARS-CoV-2 infection: an update. Front Cell Infect Microbiol. 2022 Aug 10;12:964265.


55 Mumtaz I, Ayaz MO, Khan MS, Manzoor U, Ganayee MA, Bhat AQ, Dar GH, Alghamdi BS, Hashem AM, Dar MJ, Ashraf GM and Maqbool T (2022) Clinical relevance of biomarkers, new therapeutic approaches, and role of post-translational modifications in the pathogenesis of Alzheimer’s disease. Front. Aging Neurosci. 14:977411.


56 Awuah WA, Toufik AR, Yarlagadda R, Mikhailova T, Mehta A, Huang H, Kundu M, Lopes L, Benson S, Mykola L, Vladyslav S, Alexiou A, Alghamdi BS, Hashem AM, Md Ashraf G. Exploring the role of Nrf2 signaling in glioblastoma multiforme. Discov Oncol. 2022 Sep 28;13(1):94.


57 Dhar R, Mukherjee S, Mukerjee N, Mukherjee D, Devi A, Ashraf GM, Alserihi RF, Tayeb HH, Hashem AM, Alexiou A, Thorate N. Interrelation between extracellular vesicles miRNAs with chronic lung diseases. J Cell Physiol. 2022 Sep 5


58 Mahmoud AB, Ajina R, Aref S, Darwish M, Alsayb M, Taher M, AlSharif SA, Hashem AM, Alkayyal AA. Advances in immunotherapy for glioblastoma multiforme. Front Immunol. 2022 Oct 12;13:944452.


59 Ayesha, Ahmad S, Saba S, Kashif M, Khan DA, Haque A, Naseer MI, Abuzenadah AM, Hashem AM, Rehman SU. The Relationship between Psychological Disability and Religious Practice and Coping Strategies in Caregivers of Children with Traumatic Brain Injury in Pakistani Population. Healthcare (Basel). 2022 Oct 28;10(11):2158.


60 Lucas LF, Araújo E, Gigante J, Silva S, Yousafzai Y, Teklemariam AD, Hashem AM, Vieira P, André ME, Harakeh S. Coagulopathy and Thromboembolism in Covid-19- A Review. J Pulmonol Res Rep, 2022. Volume 4(1): 1-7.


2021 Publications

1 Alharbi NK, Alghnam S, Algaissi A, Albalawi H, Alenazi MW, Albargawi AM, Alharbi AG, Alhazmi A, Al Qarni A, Alfarhan A, Zowawi HM. Nationwide Seroprevalence of SARS-CoV-2 in Saudi Arabia. Journal of infection and public health. 2021 Apr 24.


2 Ramos‐Mandujano G, Salunke R, Mfarrej S, Rachmadi AT, Hala S, Xu J, Alofi FS, Khogeer A, Hashem AM, Almontashiri NA, Alsomali A. A robust, safe, and scalable magnetic nanoparticle workflow for RNA extraction of pathogens from clinical and wastewater samples. Global Challenges. 2021 Apr;5(4):2000068.


3 Bi C, Ramos-Mandujano G, Tian Y, Hala S, Xu J, Mfarrej S, Esteban CR, Delicado EN, Alofi FS, Khogeer A, Hashem AM. Simultaneous detection and mutation surveillance of SARS-CoV-2 and multiple respiratory viruses by rapid field-deployable sequencing. Med. 2021 Mar 31.


4 Takahashi M, Tehseen M, Salunke R, Takahashi E, Mfarrej S, Sobhy MA, Alhamlan FS, Hala S, Ramos-Mandujano G, Al-Qahtani AA, Alofi FS. Quick and Easy Assembly of a One-Step qRT-PCR Kit for COVID-19 Diagnostics Using In-House Enzymes. ACS omega. 2021 Mar 15;6(11):7374-86.


5 Alserehi HA, Alqunaibet AM, Al-Tawfiq JA, Alharbi NK, Alshukairi AN, Alanazi KH, Saleh GM, Alshehri AM, Almasoud A, Hashem AM, Alruwaily AR. Seroprevalence of SARS-CoV-2 (COVID-19) among healthcare workers in Saudi Arabia: comparing case and control hospitals. Diagnostic Microbiology and Infectious Disease. 2021 Mar 1;99(3):115273.


6 Alluhaybi KA, Alharbi RH, Alhabbab RY, Aljehani ND, Alamri SS, Basabrain M, Alharbi R, Abdulaal WH, Alfaleh MA, Tamming L, Zhang W. Cellular and humoral immunogenicity of a candidate DNA Vaccine Expressing SARS-CoV-2 Spike Subunit 1. Vaccines. 2021 Aug;9(8):852.


7 Alhabbab RY, Alsaieedi A, Algaissi A, Almahboub S, Al-Raddadi RM, Shabouni OI, Alhabbab R, Alfaraj AA, Alamri SS, Aljehani ND, Abdulal RH. Seroprevalence of SARS-CoV-2 binding and neutralizing antibodies in healthcare workers during the epidemic peak in referral hospitals and quarantine sites: Saudi Arabia. Viruses. 2021 Jul;13(7):1413.


8 Alamri SS, Alluhaybi KA, Alhabbab RY, Basabrain M, Algaissi A, Almahboub S, Alfaleh MA, Abujamel TS, Abdulaal WH, ElAssouli M, Alharbi RH. Synthetic SARS-CoV-2 Spike-Based DNA Vaccine Elicits Robust and Long-Lasting Th1 Humoral and Cellular Immunity in Mice. Frontiers in microbiology. 2021:2412.


9 Al-Khateeb RS, Althagafy HS, ElAssouli MZ, Nori DA, AlFattani M, Al-Najjar SA, Al Amri T, Hashem AM, Harakeh S, Helmi N. Iron Chelation Reduces DNA Damage in Sickle Cell Anemia. Clinical and Applied Thrombosis/Hemostasis. 2021 Oct;27:10760296211047230.


10 Riaz SK, Khan W, Wang F, Khaliq T, Malik A, Razia ET, Khan JS, Haque S, Hashem AM, Alkhayyat SS, Azhar NE. Targeted Inhibition of Fibroblast Growth Factor Receptor 1-GLI Through AZD4547 and GANT61 Modulates Breast Cancer Progression. Frontiers in cell and developmental biology. 2021;9.


11 Alamer E, Alhazmi A, Qasir NA, Alamer R, Areeshi H, Gohal G, Qadri M, Hashem AM, Algaissi A. Side Effects of COVID-19 Pfizer-BioNTech mRNA Vaccine in Children Aged 12–18 Years in Saudi Arabia. Vaccines. 2021 Nov;9(11):1297.


12 Barefah AS, Radhwi OO, Alamri SS, Alahwal HM, Denetiu I, Almohammadi AT, Bahashwan SM, Qari MH, Algaissi A, Alamer E, Alhazmi A. Low clinical utility of testing for anti‐platelet factor 4 in asymptomatic individuals after ChAdOx1 nCoV‐19 vaccine. International Journal of Laboratory Hematology. 2021 Nov 30.


13 Alhazmi A, Alamer E, Abdelwahab S, Khamjan N, Hamami A, Haddad M, Darraj M, Hashem AM, Algaissi A. Community-Based Seroprevalence of SARS-CoV-2 Antibodies following the First Wave of the COVID-19 Pandemic in Jazan Province, Saudi Arabia. International Journal of Environmental Research and Public Health. 2021 Jan;18(23):12451.


14 Gravel C, Muralidharan A, Duran A, Zetner A, Pfeifle A, Zhang W, Hashem A, Tamming L, Farnsworth A, Loemba H, Chen W. Synthetic vaccine affords full protection to mice against lethal challenge of influenza B virus of both genetic lineages. Iscience. 2021 Nov 19;24(11):103328.


15 Tamming LA, Duque D, Tran A, Zhang W, Pfeifle A, Laryea E, Wu J, Raman SNT, Gravel C, Russel MSl, Hashem AM, Alsulaiman SM, Alhabbab R, Gao J, Safronetz D, Cao J, Wang L, Chen W, Johnston MJW, Sauve S, Rosu-Myles M, Li X. DNA based vaccine expressing SARS-CoV-2 spike-CD40L fusion protein confers protection against challenge in a Syrian hamster model. Front. Immunol. 2021


16 Zawawi A, Naser AY, Alwafi H, Minshawi F. Profile of Circulatory Cytokines and Chemokines in Human Coronaviruses: A Systematic Review and Meta-Analysis. Frontiers in immunology. 2021 May 5;12:1453.


17 AlSaieedi A, Salhi A, Tifratene F, Raies AB, Hungler A, Uludag M, Van Neste C, Bajic VB, Gojobori T, Essack M. DES-Tcell is a knowledgebase for exploring immunology-related literature. Sci Rep. 2021 Jul 12;11(1):14344. doi: 10.1038/s41598-021-93809-1


18 Alhabbab RY, Lombardi G. Purification and Immunophenotypic Characterization of Human CD24hiCD38hi and CD24hiCD27+ Regulatory B Cells in Transplantation. Methods Mol Biol. 2021;2270:451-467. doi: 10.1007/978-1-0716-1237-8_24


19 Romano M, Sen M, Scottà C, Alhabbab RY, Rico-Armada A, Lechler RI, Burch M, Lombardi G. Isolation and expansion of thymus-derived regulatory T cells for use in pediatric heart transplant patients. Eur J Immunol. 2021 Aug;51(8):2086-2092. doi: 10.1002/eji.202048949


20 Abuaish S, Al-Otaibi NM, Abujamel TS, Alzahrani SA, Alotaibi SM, AlShawakir YA, Aabed K, El-Ansary A. Fecal transplant and Bifidobacterium treatments modulate gut Clostridium bacteria and rescue social impairment and hippocampal BDNF expression in a rodent model of autism. Brain Sciences. 2021 Aug;11(8):1038.


21 Abuaish S, Al-Otaibi NM, Aabed K, Abujamel TS, Alzahrani SA, Alotaibi SM, Bhat RS, Arzoo S, El-Ansary A. The role of sex-differentiated variations in stress hormones, antioxidants, and neuroimmune responses in relation to social interaction impairment in a rodent model of autism. Metabolic Brain Disease. 2021 Apr 17:1-1.


22 Najjar A, Hassan EA, Zabermawi N, Saber SH, Bajrai LH, Almuhayawi MS, Abujamel TS, Almasaudi SB, Azhar LE, Moulay M, Harakeh S. Optimizing the catalytic activities of methanol and thermotolerant Kocuria flava lipases for biodiesel production from cooking oil wastes. Scientific Reports. 2021 Jul 1;11(1):1-9.


23 Mahmoud Amer E, Saber SH, Abo Markeb A, Elkhawaga AA, Mekhemer I, Zohri AN, Abujamel TS, Harakeh S, Abd-Allah EA. Enhancement of β-glucan biological activity using a modified acid-base extraction method from Saccharomyces cerevisiae. Molecules. 2021 Jan;26(8):2113.


24 Qadir A, Jahan S, Aqil M, Warsi MH, Alhakamy NA, Alfaleh MA, Khan N, Ali A. Phytochemical-Based Nano-Pharmacotherapeutics for Management of Burn Wound Healing. Gels. 2021 Dec;7(4):209.


25 Md S, Alhakamy NA, Alfaleh MA, Afzal O, Altamimi AS, Iqubal A, Shaik RA. Mechanisms Involved in Microglial-Interceded Alzheimer’s Disease and Nanocarrier-Based Treatment Approaches. Journal of Personalized Medicine. 2021 Nov;11(11):1116.


26 Akhter MH, Khalilullah H, Gupta M, Alfaleh MA, Alhakamy NA, Riadi Y, Md S. Impact of Protein Corona on the Biological Identity of Nanomedicine: Understanding the Fate of Nanomaterials in the Biological Milieu. Biomedicines. 2021 Oct;9(10):1496.


27 Bandopadhyay R, Singh T, Ghoneim MM, Alshehri S, Angelopoulou E, Paudel YN, Piperi C, Ahmad J, Alhakamy NA, Alfaleh MA, Mishra A. Recent developments in diagnosis of epilepsy: scope of microRNA and technological advancements. Biology. 2021 Nov;10(11):1097.


28 Md S, Alhakamy NA, Aldawsari HM, Husain M, Khan N, Alfaleh MA, Asfour HZ, Riadi Y, Bilgrami AL, Akhter MH. Plumbagin-Loaded Glycerosome Gel as Topical Delivery System for Skin Cancer Therapy. Polymers. 2021 Jan;13(6):923.


29 Bannan D, Ali N, Alhakamy NA, Alfaleh MA, Alharbi WS, Rashid MI, Rajeh N, Malarvannan G. Brominated Flame Retardants in Children's Room: Concentration, Composition, and Health Risk Assessment. Int J Environ Res Public Health. 2021 Jun 14;18(12):6421. doi: 10.3390/ijerph18126421.


30 Alhakamy NA, Badr-Eldin SM, Alharbi WS, Alfaleh MA, Al-Hejaili OD, Aldawsari HM, Eid BG, Bakhaidar R, Drago F, Caraci F, Caruso G. Development of an Icariin-Loaded Bilosome-Melittin Formulation with Improved Anticancer Activity against Cancerous Pancreatic Cells. Pharmaceuticals. 2021 Dec;14(12):1309.


31 Alghanmi M, Alrafiah A. 'Silymarin'a Potential Treatment Targeting Hepatic Fibrosis of Schistosomiasis.

Previous Publications

1 Ali Z, Aman R, Mahas A, Rao GS, Tehseen M, Marsic T, Salunke R, Subudhi AK, Hala SM, Hamdan SM, Pain A, Alofi FS, Alsomali A, Hashem AM, Khogeer A, Almontashiri NAM, Abedalthagafi M, Hassan N, Mahfouz MM. iSCAN: An RT-LAMP-coupled CRISPR-Cas12 module for rapid, sensitive detection of SARS-CoV-2. Virus Res. 2020 Aug 18;288:198129. doi: 10.1016/j.virusres.2020.198129.


2 Alfaleh MA, Alsaab HO, Mahmoud AB, Alkayyal AA, Jones ML, Mahler SM and Hashem AM. Phage Display Derived Monoclonal Antibodies: From Bench to Bedside. Front. Immunol. 11:1986. doi: 10.3389/fimmu.2020.01986.


3 Abu-Farha M, Thanaraj TA, Qaddoumi MG, Hashem A, Abubaker J, Al-Mulla F. The Role of Lipid Metabolism in COVID-19 Virus Infection and as a Drug Target. Int J Mol Sci. 2020 May 17;21(10):3544. doi: 10.3390/ijms21103544.


4 Almahboub SA, Algaissi A, Alfaleh MA, ElAssouli M-Z and Hashem AM (2020) Evaluation of Neutralizing Antibodies Against Highly Pathogenic Coronaviruses: A Detailed Protocol for a Rapid Evaluation of Neutralizing Antibodies Using Vesicular Stomatitis Virus Pseudovirus-Based Assay. Front. Microbiol. 2020 11:2020. doi: 10.3389/fmicb.2020.02020.


5 Hashem AM, Alghamdi BS, Algaissi AA, Alshehri FS, Bukhari A, Alfaleh MA, Memish ZA. Therapeutic use of chloroquine and hydroxychloroquine in COVID-19 and other viral infections: A narrative review. Travel Med Infect Dis. 2020;35:101735. doi:10.1016/j.tmaid.2020.101735.


6 Algaissi AA, Alharbi NK, Hassanain M, Hashem AM. Preparedness and response to COVID-19 in Saudi Arabia: Building on MERS experience. J Infect Public Health. 2020;13(6):834-838. doi:10.1016/j.jiph.2020.04.016.


7 Alharbi NK, Qasim I, Almasoud A, Aljami HA, Alenazi MW, Alhafufi A, Aldibasi OS, Hashem AM, Kasem S, Albrahim R, Aldubaib M, Almansour A, Temperton NJ, Kupke A, Becker S, Abu-Obaidah A, Alkarar A, Yoon IK, Azhar E, Lambe T, Bayoumi F, Aldowerij A, Ibrahim OH, Gilbert SC, Balkhy HH. Humoral Immunogenicity and Efficacy of a Single Dose of ChAdOx1 MERS Vaccine Candidate in Dromedary Camels. Sci Rep. 2019 Nov 8;9(1):16292. doi: 10.1038/s41598-019-52730-4.


8 Hashem AM, Algaissi A, Agrawal AS, Al-Amri SS, Alhabbab RY, Sohrab SS, S Almasoud A, Alharbi NK, Peng BH, Russell M, Li X, Tseng CK. A Highly Immunogenic, Protective, and Safe Adenovirus-Based Vaccine Expressing Middle East Respiratory Syndrome Coronavirus S1-CD40L Fusion Protein in a Transgenic Human Dipeptidyl Peptidase 4 Mouse Model. J Infect Dis. 2019 Oct 8;220(10):1558-1567. doi: 10.1093/infdis/jiz137.


9 Alfaleh MA, Arora N, Yeh M, de Bakker CJ, Howard CB, Macpherson P, Allavena RE, Chen X, Harkness L, Mahler SM, Jones ML. Canine CD117-Specific Antibodies with Diverse Binding Properties Isolated from a Phage Display Library Using Cell-Based Biopanning. Antibodies (Basel). 2019 Feb 12;8(1):15. doi: 10.3390/antib8010015.


10 Russell MS, Creskey M, Muralidharan A, Li C, Gao J, Chen W, Larocque L, Lavoie JR, Farnsworth A, Rosu-Myles M, Hashem AM, Yauk CL, Cao J, Van Domselaar G, Cyr T, Li X. Unveiling Integrated Functional Pathways Leading to Enhanced Respiratory Disease Associated With Inactivated Respiratory Syncytial Viral Vaccine. Front Immunol. 2019 Mar 29;10:597. doi: 10.3389/fimmu.2019.00597.


Scientific Conferences

  • Participation titled "The Microbiome in Health and Disease: Where Do We Stand?" at the Saudi Infectious Disease Week Conference - November 2023.

  • Participation in the Global Health Exhibition - October 2023.

  • Participation titled "Discoveries and Regionalization of Vaccine Manufacturing" at the 5th International Conference for Mass Gathering Medicine - October 2023.

  • Participation titled "Immunization Practice Guidelines and Updates" at the Saudi International Vaccination Forum - May 2023.

  • Participation in the Hevolution Global Healthspan Summit - November 2023.

  • Participation titled "The Experience of King Fahd Medical Research Center in Research and Development" at the Conference of the Faculty of Applied Medical Sciences, Taibah University - January 2023.

  • Participation with an oral presentation titled “How does pregnancy affect the serological response to SARS-CoV-2 infection over time?” at the RCOG 2022 Global Conference – June 2022

  • Participation as a speaker entitled “Selection of Transiently Expressed Membrane Protein Antibodies Using Phage Display and Fluorescence-Activated Cell Sorting” – Speaker Dr. Muhammad Al-Falih, at the Oxford Conference on Phage Bacteria - 2021

Patents

  • Patent titled "Method for inducing immune response against Middle East respiratory syndrome-coronavirus using trimeric S1-CD40L fusion protein" in the field of biotechnology. Description: A method to generate immunity against Middle East respiratory syndrome-coronavirus using a vaccine. Inventor: Anwar M. Hashem. Release Date: May 30, 2023.

  • Patent titled "Synthetic plasmid DNA vaccine expressing a codon-optimized SARS-CoV-2 spike protein" in the field of biotechnology. Description: A vaccine against SARS-CoV-2. Inventors: Anwar M. Hashem, Mohamed A. Alfaleh, Turki S. Abujamel, Sawsan S. Alamri, Abdullah Algaissi, Khalid A. Alluhaybi. Release Date: March 21, 2023.

  • Patent titled “NK-lysin peptide compositions and methods of using them as antimicrobial agents / antivirals” from the United States Patent Office in the field of health, the co-inventors: Majid Mostafa, Haitham Yaqoub, Ahmed Al-Hajan, Turki Abu-Gamel and Sherif Abdel-Maqsoud - June 2022

  • Patent titled “Intranasal MERS-CoV Vaccine” from the United States Patent Office in Biotechnology, co-inventor: Anwar Hashem - November 2022

  • Patent titled “Corona Virus Vaccine Composition” from the United States Patent Office in the field of biotechnology, co-inventors: Anwar Hashem - March 2022

  • Patent titled "DNA-based vaccine against Middle East Respiratory Syndrome - Coronavirus" from the United States Patent Office in the field of biotechnology, co-inventors: Anwar Hashem - April 2022

  • Patent titled “S1-CD40L Tri-Encoding Polynucleotide Immunofusion Fusion Protein Against Middle East Coronavirus” from the United States Patent Office in the field of biotechnology, co-inventors: Anwar Hashem - December 2022

  • Patent Titled “Synthetic Plasmid DNA Vaccine Expressing Sars-CoV-2 Spinal Cidin-Enhanced Protein and Methods for Its Use” from the US Patent Office in Biotechnology - September 2022

  • Patent titled "MERS-CoV vaccine with trimeric S1-CD40L fusion protein" in the field of biotechnology - investment entity SaudiVax - 2021

  • Patent titled "Formulation and treatment method of Middle East Respiratory Syndrome" in the field of biotechnology - investment entity SaudiVax - 2020

  • Patent titled "Trimeric S1-CD40L Fusion Protein Vaccine against Coronavirus Middle East" in the field of biotechnology - investment entity SaudiVax - 2018

  • Patent titled “MERS-CoV Vaccine with Triple S1-CD40L Fusion Protein” in the field of biotechnology, co-inventor: Anwar Hashem - 2021

  • Patent titled “Methods of Diagnosis and Treatment of Inflammatory Bowel Diseases” in the field of health. The co-inventors are: Alan Stentzi, David R. Mack, Joseph Michel, Daniel Figes, Walid Abdel-Fattah Al-Sayed Mutawa, Turki Saleh A. Abu Jamal and Cheng Kang Xiang- 2021

  • Patent titled "Chicken Cathelicidin as a Treatment for Cancer" in the field of health, the participants in the invention: Majid Muhammad Mahmoud, Haitham Yaqoub, Ahmed Muhammad Al-Hajeen, Turki Abu Jamal, Fadwa Al-Joud, Moudi Al-Anzi and Abdul-Wahhab Norowali - 2021

  • Patent titled Biomarkers and Therapeutic Targets for GD and HT" in Health - 2021

  • Patent titled “Intranasal Vaccine for MERS-CoV” in the field of Biotechnology- 2021

  • Patent titled "pPh SIRIUS-38: Phage display vector for cloning and expression of antibody fragments" in the field of biotechnology - 2021

Professional Advice

  • Establishing a training center in the field of biotechnology in partnership with SaudiVax, aimed at enhancing talent in biotechnology and preparing graduates for the industry.

    • Expert opinion and advice on the localization of vaccines and biological treatments - Ministry of Industry
  • Expert opinion and advice on immunization - Ministry of Health

  • WHO meeting on the R&D blueprint: New variants of the Covid-19 virus, knowledge gaps and research - Global Health Organization

  • WHO meeting on the R&D blueprint: Systematic approaches to assess the impact of variables on vaccine efficacy, efficacy and impact - Global Health Organization

  • WHO meeting on the R&D blueprint: the global consultation on COVID-19 therapeutics - Global Health Organization

  • WHO R&D blueprint meeting: Consultation on the use of trained dogs for screening of COVID-19 cases - Global Health Organization

  • WHO Meeting on R&D Blueprint: Global Workshop on SARS-CoV-2 Sequencing Enhancement - Global Health Organization

  • WHO meeting on the R&D blueprint: community-based responses to health emergencies: progress, gaps and research priorities - Global Health Organization

  • WHO meeting on R&D outline: COVID-19 vaccine research and development - Global Health Organization

  • WHO R&D Blueprint Meeting: What is the role of immunostimulants in the evaluation of COVID-19 vaccines? - Global Health Organization

  • WHO meeting on R&D Blueprint: Global Research and Innovation Forum COVID-19 - Global Health Organization

  • WHO Meeting on Research and Development Outline: COVID-19 Vaccines - WHO Protection Links Meeting - Global Health Organization

  • WHO R&D blueprint meeting: global consultation on variants of concern for SARS-CoV-2 and their impact on public health interventions - Global Health Organization

  • WHO R&D Blueprint Meeting: WHO Consultation on COVID-19 Vaccine Research: Can Booster Doses Contribute to Controlling this Epidemic: What Research is Needed? - Global Health Organization

  • WHO R&D blueprint meeting: Will emerging data allow greater reliance on immune responses to vaccines in public health and regulatory decision-making? - Global Health Organization

  • WHO R&D Blueprint Meeting: WHO Consultation on COVID-19 Vaccine Research: Emerging Evidence on Additional Doses and Safety of COVID-19 Vaccines - Global Health Organization

  • WHO R&D blueprint meeting: WHO research into COVID-19 vaccines: How can vaccine research contribute most to achieving control of the pandemic everywhere? - Global Health Organization

  • WHO R&D Blueprint Meeting: WHO Global Consultation - What evidence do we have that Omicrons evade immunity and what are the implications?- WHO

Members

Team Members

Prof. Anwar Hashim

Head of Unit
51377

Dr. Mohammad Alfaleh

Researcher

Dr. Turky Abujamel

Researcher
68154

Dr. Rawa Ahabbab

Researcher

Dr. Ahdab Alsaedi

Researcher

Dr. Ayat Alzawawi

Researcher

Dr. Torfah Altorki

Researcher

Dr. Aysha Alnaemi

Researcher

Dr. Mymounah Alghamdi

Researcher

Dr. Khalil Alkowaity

Researcher

Dr. Alaa Alzahrani

Researcher

Dr. Wafa Arab

Researcher

Dr. Leena Nazamuddin

Researcher

Dr. Shimaa Abdulaal

Researcher

Dr. Jawaher Mokhtar

Researcher

Dr. Khaled Alluhaibi

Researcher

Dr. Najat Bin Othman

Researcher

Reem Alsulaiman

Assistant Researcher

Badr Almasri

Researcher

Zaki Assouli

Assistant Researcher

Dr. Heba Halawa

Researcher

Dr. Abdullah Alqiasi

Researcher

Dr. Ahmad Bakur Mahmoud

Researcher

Dr. Faisal Menshawi

Researcher

Dr. Hanan Niaz

Researcher

Education

Training & Students Supervision

Phd. Postgraduate students supervision

Phd. Students
  • Asem Alsahreif
  • Dua Jamal
  • Ghadeer Shori
  • Raneem Alharbi
  • Najwa Aljuhani
  • Nour Alghoufi
  • Saleimah Shibo
  • Zakiyah Fallath
  • Mohammad Khan
  • Rawa Abdulaal
  • Aiysha Ghazawni
  • Shimaa Alhazmi
  • Reem Alsherif
postgrad
M.Sc postgraduate students supervision

M.Sc Students
  • Amjad Al Wudhani
  • Mayada Al Safiani
  • Lama Al Nizawi
  • Abar Al Saedi
  • Balkis Qouta
  • Tamader Al Jilani
  • Mohammed Al Ghamdi
  • Mohammed Basbreen
  • Afnan Al Mahamadi
  • Haya Hawbani
  • Rafidah Al Saqqaf
  • Wala'a Qattan
  • Yusra Shukri
  • Rasha Al Shuhari
  • Suad Al Salami
  • Mohammed Al Shuqair
  • Asalah Hilal
  • Abdulaziz Kalatham
  • Rami Al Khalidi
postgrad
Undergraduate & high school(Mawheba) students supervision

Bachelor & Mawheba Students
  • Marwan Al Juhani
  • Faisal Al Malki
  • Ghada Al Juhani
  • Amna Al Jazani
  • Fares Al Yammi
  • Jood Baloula
  • Layla Zwawi
  • Rahef Al Shabani
postgrad
Graduated Students
  • Farah Sakariya
  • Sawsan Alamri
  • Alaa Alnemari
  • Sara Alnoumani
  • Rakan Felimban
  • Rawan Muslum
  • Nouf Althobaiti
  • Hala Fizo
  • Mohammad Alghamdi
  • Abdulaziz Alshengeti
  • Rawa Abdulaal
  • Yasir Alraddadi
  • Reema Bawazir
  • Mohammad Abdu
  • Reem Aljuhani
  • Mawada Bajaber
  • Sherin Ashi
  • Sara Radwan
  • Noura Alotaibi
  • Afnan Dagnah
  • Abdulaziz Alghamdi
  • Manar Mousa
  • Ghyda Alkhateeb
  • Haneen Naser
  • Shahad Hamza
  • Asmaa Alnahdi
  • Kholoud Alnahdi
  • Shoroug Algouei
postgrad
Contact

Contact Us

kfmrc-viu@kau.edu.sa

King Fahd Medical Research Center

kfmrc@kau.edu.sa

00966-12-695-2000 ext. (25027 ,61453)

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KFMRC
Last Update
5/28/2024 12:49:40 PM