kfmrc@kau.edu.sa
00966-12-695-2000 Ext. (25027 ,61453)
Experimental Biochemistry Unit
The experimental biochemistry unit is based on five branches of contemporary biochemistry: immune biochemistry, molecular biochemistry, clinical biochemistry, biochemistry for nutrition, natural products, and microbial biochemistry. The unit focuses on implementing various research projects related to the mentioned fields.
These research projects contribute to the development of technical expertise among postgraduate students. The experimental biochemistry unit also contributes to the advancement of basic and applied research in field of biochemistry and technology beside Natural products, plants, and herbs.
Research Areas
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Drug discovery
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Biomechanical assessment and identification
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Vaccine development and design
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Natural products, plants and herbs
+53
Publications
+2
Scientific Activities
+5
Patents
+7
Education and Training
+8
Partnerships & Consultations
+25
Students
Research Output
Scientific Acheivemnets
2023 Publications
| 1 |
Genetic Variants in the Mitochondrial Thymidylate Biosynthesis Pathway Increase Colorectal Cancer Risk by
Entesar M Arrait, Ayat B Al-Ghafari, Huda A Al Doghaither
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| 2 |
Role of mitochondrial disruption and oxidative stress in plasticizer phthalate-induced cytotoxicity to human bone osteoblasts by
Ekramy Mahmoud Elmorsy, Ayat Al-Ghafari, Huda Al Doghaither
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| 3 |
5-Fluorouracil and capecitabine therapies for the treatment of colorectal cancer (Review)
by Shiekhah M Alzahrani, Huda A Al Doghaither, Ayat B Al-Ghafari, Peter N Pushparaj
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| 4 |
Possible Inhibition of Renal Protein Glycation by Carnosine
and Tocopherol in Diabetic Rat by
Etimad Huwait, Maryam A. Al-Ghamdi, Faisal S. Al-Shehri
, Said S. Moselhy
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| 5 |
Inhibition of dipeptidyl peptidase-4 (DPP4), antioxidant, antiglycation and anti-inflammatory effect of Ferulic acid against streptozotocin toxicity mediate nephropathy in diabetic rats
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| 6 |
Therapeutic effect of combination vitamin D3 and siponimod on remyelination and modulate microglia activation in cuprizone mouse model of multiple sclerosis by
Kholoud M. Al-Otaibi, Badrah S. Alghamdi, Maryam A. Al-Ghamdi, Rasha A. Mansouri1 Ghulam Md Ashraf, Ulfat M. Omar1
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| 7 |
Thymoquinone ameliorates acrylamide-induced reproductive toxicity in female rats:
An experimental study by
Maryam AL-ghamdi1, Etimad Huwait, Nagwa Elsawi,
Soad Shaker Ali, Ahmed Sayed
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| 8 |
Rhus tripartite methanolic extract alleviates propylparaben-induced reproductive toxicity via anti-inflammatory, antioxidant, 5-α reductase in male rats. by Mosaoa, R.M., Kumosani, T.A., Yaghmoor, S.S. et al. Environ Sci Pollut Res 30, 76969–76976
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| 9 |
Atheroprotective Effect of Fucoidan in THP-1 Macrophages by Potential Upregulation of ABCA1
by Zeenat Mirza, Dalal A. Al-Saedi, Salma Saddeek, Sanaa Almowallad, Rehab F. AlMassabi and Etimad Huwait
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| 10 |
Integration of palliative care in the management of oral squamous cell carcinoma Republica et al. Bioinformation 19(1): 1-4 (2023)
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| 11 |
Microarray Expression Profile of Myricetin-Treated THP-1 Macrophages Exhibits Alterations in Atherosclerosis-Related Regulator Molecules and LXR/RXR Pathway
by Etimad Huwait, Rehab Almassabi, Sanaa Almowallad, Salma Saddeek, Sajjad Karim, Gauthaman Kalamegam and Zeenat Mirza
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| 12 |
Identification of novel interacts partners of ADAR1 enzyme mediating the oncogenic process in aggressive breast cancer by
Najat Binothman, Majidah Aljadani, Bandar Alghanem, Mohammed Y. Refai, Mamoon Rashid, Abeer Al Tuwaijri, Nouf H. Alsubhi, Ghadeer I. Alrefaei, Muhammad Yasir Khan, Sultan N. Sonbul, Fadwa Aljoud, Sultan Alhayyani, Rwaa H. Abdulal, Magdah Ganash & Anwar M. Hashem
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| 13 |
Optimal Deep Transfer Learning Based Colorectal Cancer Detection and Classification Model by
Mahmoud Ragab, Maged Mostafa Mahmoud, Amer H. Asseri, Hani Choudhry, Haitham A. Yacoub
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| 14 |
Antioxidant activity and inhibitory effect of 2,4,4'-trihydroxychalcone on digestive enzymes related to obesity
Authors
Hadeil Alsufiani
, Ghaynat A. Aldhaheri
, Ulfat M. Omar
, Taraji M. Bahdilah
, Rasha A. Mansour
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| 15 |
Salivary Hormones Leptin, Ghrelin, Glucagon, and Glucagon-Like Peptide 1 and Their Relation to Sweet Taste Perception in Diabetic Patients by
Nada K. Al-Ghurayr
, Ashjan M. Al-Mowalad
, Ulfat M. Omar
, Heba M. Ashi
, Saad S. Al-Shehri
, Abdelrahman A. AlShaikh
, Shada M. AlHarbi
and Hadeil M. Alsufiani
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| 16 |
A new cirrhotic animal protocol combining carbon tetrachloride with methotrexate to address limitations of the currently used chemical-induced models by
Rasha A. Mansouri, Adel M. Ahmed, Huda F. Alshaibi, Maha M. Al-Bazi, Abeer A. Banjabi, Hadeil Muhanna Alsufiani, Akram Ahmed Aloqbi, Esam M. Aboubakr
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| 17 |
Cell Growth Inhibition, DNA Fragmentation and Apoptosis-Inducing Properties of Household-Processed Leaves and Seeds of Fenugreek (Trigonella Foenum-Graecum Linn.) against HepG2, HCT-116, and MCF-7 Cancerous Cell Lines
by Shaimaa G. Abdel Salam, Mohamed M. Rashed, Nabih A. Ibrahim, Emam A. Abdel Rahim , Hadeil Muhanna Alsufiani , Rasha A. Mansouri, Mohamed Afifi and Ammar Al-Farga
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| 18 |
Formulation of chrysin loaded nanostructured lipid carriers using Box Behnken design, its characterization and antibacterial evaluation alone and in presence of probiotics co-loaded in gel, by Shaik Rahana Parveen, Sheetu Wadhwa, Molakpogu Ravindra Babu, Sukriti Vishwas, Leander Corrie, Ankit Awasthi, Farhan R. Khan, Maha M. Al-Bazi, Nahed S. Alharthi, Faisal Alotaibi, Gaurav Gupta, Narendra Kumar Pandey, Bimlesh Kumar, Popat Kumbhar, John Disouza, Monica Gulati, Jayanthi Neelamraju, Ratna Sudha Madempudi, Kamal Dua, Sachin Kumar Singh, Journal of Drug Delivery Science and Technology,Volume 84,2023,104411 |
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| 19 |
Protective effect of barbigerone against ethanol-induced ulcers via the interleukins/ICAM-1/Bcl-2 pathway by European Review for Medical and Pharmacological Sciences 27 (2023): 12029-12042.
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| 20 |
Influence of rosiridin on streptozotocin-induced diabetes in rodents through endogenous antioxidants-inflammatory cytokines pathway and molecular docking study, by Imran Kazmi, Fahad A. Al-Abbasi, Shareefa A. AlGhamdi, Amira M. Alghamdi, Mustafa Zeyadi, Ryan A. Sheikh, Gaurav Gupta & Nadeem Sayyed (2023) Journal of Biomolecular Structure and Dynamics, DOI: 10.1080/07391102.2023.2282738
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2022 Publications
| 1 |
Oxygen scavenging, anti-inflammatory, and antiglycation activity of pomegranate flavonoids (Punica granum) against streptozotocin toxicity induced diabetic nephropathy in rats Mosaoa, Rami M. ; Yaghmoor, Soonham S. ; Moselhy, Said S. Published 2022 |
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| 2 |
Kumosani, T. A., Al-Bogami, T. J., Barbour, E. K., Alshehri, S. H., Yaghmoor, S. S., Alshareef, N. A., ... & Moselhy, S. S. (2022). Leishmaniasis prevalence, awareness and control in Saudi Arabia. African Health Sciences, 22(3), 640-647.
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| 3 |
Abulnaja, K., Bakkar, A., Kannan, K., Al-Manzlawi, A. M., Kumosani, T., Qari, M., & Moselhy, S. (2022). Olive leaf (Olea europaea L. folium) extract influences liver microsomal detoxifying enzymes in rats orally exposed to 2-amino-l-methyI-6-phenyI-imidazo pyridine (PhIP). Environmental Science and Pollution Research, 1-9.
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| 4 |
Al-Ghamdi, M. A., Alsulami, R. R., Bakkar, A., Kumosani, T. A., Barrbour, E. K., Abulnaja, K. O., ... & Moselhy, S. S. (2022). Khalas date flavonoids inhibited cell viability, induced apoptosis and expression of the pro-autophagy LC3-B gene in human hepatocellular carcinoma cells (HepG2). Natural Product Research, 1-5.
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| 5 |
Banjabi, A. A., Kurunthachalam, K., Kumosani, T. A., Abulnaja, K. O., Al-Malki, A. L., & Moselhy, S. S. (2022). Serum heavy metals of passive smoker females and its correlation to bone biomarkers and risk of osteoporosis. Environmental Science and Pollution Research, 29(5), 6943-6948.
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| 6 |
Al-Bazi, M. M., Kumosani, T. A., Al-Malki, A. L., Kannan, K., & Moselhy, S. S. (2022). Screening the incidence of diabetogensis with urinary phthalate in Saudi subjects. Environmental Science and Pollution Research, 29(19), 28743-28748.
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| 7 |
Abulnaja, K. O., Kannan, K., Al-Manzlawi, A. M. K., Kumosani, T. A., Qari, M., & Moselhy, S. S. (2022). Sensitivity, specificity of biochemical markers for early prediction of endothelial dysfunction in atherosclerotic obese subjects. African Health Sciences, 22(2), 286-294.
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| 8 |
Huwait, E., Awaji, S. M., Kumosani, T. A., Barbour, E. K., Abulnaja, K. O., & Moselhy, S. S. (2022). Ruthana date extract inhibited proliferation of human hepatocellular carcinoma (HepG2) cells by modulation of BAX gene. Environmental Science and Pollution Research, 1-10.
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| 9 |
Abulnaja, K. O., Kannan, K., Al-Manzlawi, A. M. K., Kumosani, T. A., Qari, M., & Moselhy, S. S. (2022). Ajwa date flavonoids mitigate neutrophil migration and interferon-γ-induced renal injury by ultraviolet C radiation in rats. Environmental Science and Pollution Research, 1-7.
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| 10 |
Alsunusi, S., Kumosani, T. A., Glabe, C. G., Huwait, E. A., & Moselhy, S. S. (2022). In vitro study of the mechanism of intraneuronal β-amyloid aggregation in Alzheimer’s disease. Archives of Physiology and Biochemistry, 128(3), 732-739.
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2021 Publications
| 1 |
Al-Malki AL, Bakkar A, Huwait EA, Barbour EK, Abulnaja KO, Kumosani TA, Moselhy SS. Strigol1/albumin/chitosan nanoparticles decrease cell viability, induce apoptosis and alter metabolomics profile in HepG2 cancer cell line. Biomedicine & Pharmacotherapy. 2021 Oct 1;142:111960.
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| 2 |
Banjabi AA, Kurunthachalam K, Kumosani TA, Abulnaja KO, Al-Malki AL, Moselhy SS. Serum heavy metals of passive smoker females and its correlation to bone biomarkers and risk of osteoporosis. Environmental Science and Pollution Research. 2021 Aug 31:1-6.
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| 3 |
Banjabi AA, Kannan K, Kumosani TA, Yousef JM, Abulnaja KO, Moselhy SS. Association of blood heavy metal levels with osteocalcin abnormality and incidence of osteoporosis in Saudi subjects. Brazilian Journal of Biology. 2021 Sep 15;83.
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| 4 |
Al-Bazi MM, Kumosani TA, Al-Malki AL, Kannan K, Moselhy SS. Association of trace elements abnormalities with thyroid dysfunction. African Health Sciences. 2021 Sep 27;21(3):1451-9.
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| 5 |
Aloutaibi GT, Al-Malki AL, Balgoon MJ, Bahaidarah SA, Moselhy SS. Rheumatic Heart Disease and Its Association with H. pylori Infection. Journal of Pure and Applied Microbiology. 2021 Jun 1;15(2):580-7.
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| 6 |
Huwait EA, Saddeek SY, Al-Massabi RF, Almowallad SJ, Pushparaj PN, Kalamegam G. Antiatherogenic Effects of Quercetin in the THP-1 Macrophage Model In Vitro, With Insights Into Its Signaling Mechanisms Using In Silico Analysis. Frontiers in Pharmacology. 2021:1723.
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| 7 |
Fouad MA, Sayed-Ahmed MM, Huwait EA, Hafez HF, Osman AM. Epigenetic immunomodulatory effect of eugenol and astaxanthin on doxorubicin cytotoxicity in hormonal positive breast Cancer cells. BMC Pharmacology and Toxicology. 2021 Dec;22(1):1-5.
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| 8 |
Huwait, E. A., Al-Ghamdi, M. A., Ghattas, M. H., Hinnis, A. R., El-Maaty, D. A. A., Abo-Elmatty, D. M., & Abdel-Hamed, A. R. (2021). Role of heme oxygenase-1, cytokines, and vascular endothelial growth factor in murine Schistosoma mansoni. International Journal of Health Sciences, 15(1), 22.
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| 9 |
Al-Ghamdi MA, Al-Enazy A, Huwait EA, Albukhari A, Harakeh S, Moselhy SS. Enhancement of Annexin V in response to combination of epigallocatechin gallate and quercetin as a potent arrest the cell cycle of colorectal cancer. Brazilian Journal of Biology. 2021 Sep 6;83.
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| 10 |
Choudhry, H., Hassan, M. A., Al‑Malki, A. L., & Al‑Sakkaf, K. A. (2021). Suppression of circulating AP001429. 1 long non‑coding RNA in obese patients with breast cancer. Oncology Letters, 22(1), 1-15.
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| 11 |
Shahzadi, I., Al-Ghamdi, M. A., Nadeem, M. S., Sajjad, M., Ali, A., Khan, J. A., & Kazmi, I. (2021). Scale-up fermentation of Escherichia coli for the production of recombinant endoglucanase from Clostridium thermocellum. Scientific Reports, 11(1), 1-10.
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Previous Publications
| 1 |
Gingerenone A Attenuates Monocyte-Endothelial Adhesion via Suppression of I Kappa B Kinase Phosphorylation By: Kim, Hee Joo; Son, Joe Eun; Kim, Jae Hwan; et al. Journal of cellular biochemistry Volume: 119 Issue: 1 Pages: 260-268 Published: JAN 2018
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| 2 |
Multifaceted Role of a Marvel Golden Molecule, Curcumin: a Review By: Moselhy, S. S.; Razvi, S.; Hasan, N.; et al. Indian journal of pharmaceutical sciences Volume: 80 Issue: 3 Pages: 400-411 Published: MAY-JUN 2018
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| 3 |
Therapeutic Effects of Phytochemicals of Brassicaceae for Management of Obesity By: Kuerban, Abudukadeer; Yaghmoor, Soonham Sami; Almulaiky, Yaaser Q.; et al. British journal of pharmaceutical research Volume: 19 Issue: 4 Article Number: 37617 Published: 2017
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| 4 |
Potential Antioxidant and Anti-Proliferative Activities of Biologically Active Marine Algae Extracts By: Kumosani, Taha A.; Balamash, Khadijah Saeed; Ghashlan, Hanaa; et al. British journal of pharmaceutical research Volume: 19 Issue: 6 Article Number: 38089 Published: 2017
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| 5 |
Changes in erythrocyte ATPase activity under different pathological conditions By: Kherd, Ali A.; Helmi, Nawal; Balamash, Khadijah Saeed; et al. African health sciences Volume: 17 Issue: 4 Pages: 1204-1210 Published: DEC 2017
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| 6 |
Analysis of SNPs of MC4R, GNB3 and FTO gene polymorphism in obese Saudi subjects By: Moselhy, Said Salama; Alhetari, Yasmeen A.; Iyer, Archana; et al. African health sciences Volume: 17 Issue: 4 Pages: 1059-1069 Published: DEC 2017
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| 7 |
A Bioactive Constituent of Ginger, 6-Shogaol, Prevents Adipogenesis and Stimulates Lipolysis in 3T3-L1 Adipocytes By: Suk, Sujin; Seo, Sang Gwon; Yu, Jae Gak; et al. Journal of food biochemistry Volume: 40 Issue: 1 Pages: 84-90 Published: FEB 2016
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| 8 |
Utilization of nanoemulsions to enhance bioactivity of pharmaceuticals, supplements, and nutraceuticals: Nanoemulsion delivery systems and nanoemulsion excipient systems By: Aboalnaja, Khaled Omer; Yaghmoor, Soonham; Kumosani, Taha Abdullah; et al. Expert opinion on drug delivery Volume: 13 Issue: 9 Pages: 1327-1336 Published: 2016
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| 9 |
Urinary biomarkers of exposure to 57 xenobiotics and its association with oxidative stress in a population in Jeddah, Saudi Arabia By: Asimakopoulos, Alexandros G.; Xue, Jingchuan; De Carvalho, Bruno Pereira; et al. Environmental research Volume: 150 Pages: 573-581 Published: OCT 2016
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| 10 |
Impact of sporadic reporting of poultry Salmonella serovars from selected developing countries By: Barbour, Elie K.; Ayyash, Danielle B.; Alturkistni, Wafa; et al. Journal of infection in developing countries Volume: 9 Issue: 1 Pages: 1-7 Published: JAN 2015
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Scientific Conferences
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Scientific paper entitled “Evaluation of a standardized protocol for assessment of drug susceptibility of H9N2 Influenza viruses in the absence of cell culture facility ” at the 22nd Conference of the World Poultry Veterinary Association WVPA – September 2023
Patents
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Patent titled “Method for administering liposomal composition.” from the United States Patent Office in the field of Medicine and Pharmaceuticals, co-inventors Taha Qomsany, Lee Barbour, Sonham Yagmore and Warner Kroll - June 2022
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Patent entitled “Essential oil emulsion nostril treatment composition” from the United States Patent Office in the field of medicine and pharmacology, co-inventors Taha Qamazany, Lee Barbour, Sonham Yagmore and Warner Kroll - August 2022
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Patent titled “Invention of nanotechnology-based nostril drops in relief of respiratory ailments” from the United States Patent Office in the field of health, co-inventors Taha Qamazany, Lee Barbour and Sonham Yaghmour -2021
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Patent titled “Invention of SARS-CoV-2 ELISA reagents and vaccines by ‘One Process’ – Applicability to other targeted organisms and molecules" from the United States Patent Office in the field of Medicine - April 2021
Dr. Sonham Yaghmoor
Head of Unit
25405
Prof. Taha Kumosani
Consultant
Dr. Mohammad Refai
Researcher
Dr. Sultan Sunbul
Researcher
Dr. Ayat Alghafari
Researcher
Dr. Maha Albazi
Researcher
Dr. Naif Almalki
Researcher
Dr. Mariyam Alghamdi
Researcher
Dr. Etimad Howait
Researcher
Prof. Kurunthachalam Kannan
Researcher
Prof. Elie Barbour
Researcher
Dr. Angham Abdulkareem
Researcher
Dr. Shahad Alsunusi
Researcher
Dr. Salman Hosawi
Researcher
Dr. Rayan Sheikh
Researcher
Dr. Amer Asseri
Researcher
Dr. Hadeel Alsufiani
Researcher
Dr. Wedam Alghazawi
Researcher
Areej Alyahiby
Lab Specialist
Wajadan Almassabi
Lab Technician
Mazen Alharthi
Lab Technician
Education
Training & Students Supervision
Phd. Postgraduate students supervision
Phd. Students
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Eman Almuhaini
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Esraa Redhwan
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Turkiah Albogami
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Abeer Alnefaie
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Fatima Al-Issa
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Sharifa Al-Shehri
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Dalal Al-Saadi
M.Sc postgraduate students supervision
M.Sc Students
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Nouf Alshehri
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Tasneem Alagha
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Rawyia Alsulami
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Seham Alawaji
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Hanan Alhamed
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Salma Siddiqui
Graduated Students
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Noor Bashanfar
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Ibtisam Baghalib
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Shahad Alsunosi
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Maha Albazi
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Ashjan Manzlawi
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Abeer Binjabi
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Fadl Khan
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Last Update
6/4/2024 1:22:07 PM
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