kfmrc@kau.edu.sa

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About Scientific Acheivemnets Team Members Education Contact
Immunology Unit

The immunology unit studies the nature of immune cells in health and disease by monitors the development of autoimmune diseases.

The unit is concerned with isolating immune cells for diagnosis, treatment, and studies of programmed death of immune cells. The isolation and differentiation of immune dendritic cells and their applications and the estimation of cytokines and chemokines in immunological tests are of purely research importance. The unit’s vision is to become a leading unit in the field of basic and applied Immunological research that provides the best research outcomes for our society’s health.



Research Areas
  • Proliferation assays
  • Phenotypical studies
  • ELISA technology
  • Tumour cell culture
  • Apoptosis studied
  • Immunofluorescent techniques
  • Primary cell culture

+36

Publications

+2

Patents

+3

Education and Training

+1

Partnerships & Consultations

+59

Students

Research Output

Scientific Acheivemnets


2022 Publications

1 Alotaibi, K., Mufawwaz, A., Alharbi, M., Alrahimi, J., Basingab, F. and Alhazmi, S. (2022) “The Role of Alpha-1-acid Glycoprotein 2 Protein and the Underlying Orosomucoid 2 Gene in Different Diseases”, Journal of Pharmaceutical Research International, 34(20A), pp. 15-29.


2 Alrahimi J, Aldahlawi A, Hassoubah S, Al-Jadani S, Alyamani W, Alotaibi N. An Insight into the Microbiology, Epidemiology, and Host Cell Biology of Legionella Pneumophila: A Review of Literature. Biosci Biotech Res Asia 2022;19(3).


3 Alhazmi S, Alzahrani M, Farsi R, Alharbi M, Algothmi K, Alburae N, Ganash M, Azhari S, Basingab F, Almuhammadi A, Alqosaibi A, Alkhatabi H, Elaimi A, Jan M, Aldhalaan HM, Alrafiah A, Alrofaidi A. Multiple Recurrent Copy Number Variations (CNVs) in Chromosome 22 Including 22q11.2 Associated with Autism Spectrum Disorder. Pharmgenomics Pers Med. 2022 Jul 20;15:705-720.


4 Alia Aldahlawi, Afnan Alqadiri, Hadil Alahdal, Kalthoom Al-Sakkaf, Jehan Alrahimi, Fatemah Basingab. Tumor necrosis factor alpha and lipopolysaccharides synergistic effects on T-cell immunoglobulin and mucin domain 3 regulation in dendritic cells. Journal of King Saud University – Science. 2022, 34 (6).


5 Fatemah S. Basingab, Walaa E. Nuqali, Bothaina A. Alaidaroos, Najwa M. Alharbi, Reda H. Amasha and Reem M. Farsi. Biodegradation Potential of Phenol and Toluene by Marine Staphylococcus pasteuri Isolated from the Red Sea, Saudi Arabia.


6 Basingab F, Alsaiary A, Almontashri S, Alrofaidi A, Alharbi M, Azhari S, Algothmi K, Alhazmi S. Alterations in Immune-Related Defensin Alpha 4 (DEFA4) Gene Expression in Health and Disease. International Journal of Inflammation. 2022 May 28.


7 Altowairki H, Basingab FS, Abdullah ST, Hussein MA, Hadjichristidis N, Alkayal NS. New cross‐ linked poly (methyl methacrylate): Synthesis, characterization, and inhibitory effects against selected bacteria and cancer cells. Polymer Engineering & Science. 2022, 62 (7):2294-2301


8 Algothmi K, Alqurashi A, Alrofaidi A, Alharbi M, Farsi R, Alburae N, Ganash M, Azhari S, Basingab F, Almuhammadi A, Alqosaibi A, Alkhatabi H, Elaimi A, Jan M, Aldhalaan H, Alrafiah A, Alhazmi S. DNA Methylation Level of Transcription Factor Binding Site in the PromoterRegion of Acyl-CoA Synthetase Family Member 3 (ACSF3) in Saudi Autistic Children. Pharmacogenomics and Personalized Medicine. 2022, (15), 131-142


9 Alotaibi, K., Mufawwaz, A., Alharbi, M., Alrahimi, J., Basingab, F. and Alhazmi, S. The Role of Alpha-1-acid Glycoprotein 2 Protein and the Underlying Orosomucoid 2 Gene in Different Diseases”, Journal of Pharmaceutical Research International, 2022, 34(20A), pp. 15-29.


10 Safialdin Alsanosi, Ryan A. Sheikh, Sultan Sonbul, Hisham N. Altayb, Afnan S. Batubara, Salman Hosawi, Kaltoom Al-Sakkaf, Omeima Abdullah, Ziad Omran, Mahmoud Alhosin. 3. The Potential Role of Nigella sativa Seed Oil as Epigenetic Therapy of Cancer.Molecules. 2022 May; 27(9): 2779.


11 Aldahlawi, A. M, and Zaher K. A. (2022): Dendritic Cell‑Based Immunity: Screening of Dendritic Cell Subsets in Breast Cancer‑Bearing Mice. J Microsc Ultrastruct (a head of publication)


12 Zaher K.A., and Aldahlawi, A. M. (2022): Immuno-viro-lytic mediated therapy for Killing of Cancer Cells: dual- Using oncolytic virus and tumor cell lysate as future vaccine. Phrmacophore, ( a head of publication).


13 Mahmoud, M. M., Jamal, S., Qadah, T., Zaher, K.A., and Yacoub, H. A. (2022): Mitochondrial genome with intrinsic protein disorder potentiality. Egypt. J. Vet. Sci., 54 (2): 211-235.


14 Alsubhi NH, Al-Quwaie DA, Alrefaei GI, Alharbi M, Binothman N, Aljadani M, Qahl SH, Jaber FA, Huwaikem M, Sheikh HM, Alrahimi J, Abd Elhafez AN, Saad A. Pomegranate Pomace Extract with Antioxidant, Anticancer, Antimicrobial, and Antiviral Activity Enhances the Quality of Strawberry-Yogurt Smoothie. Bioengineering (Basel). 2022 Nov 28;9(12):735.


2021 Publications

1 Hadad SE, Alsolami M, Aldahlawi A, Alrahimi J, Basingab F, Hassoubah S, Alothaid H. In vivo evidence: Repression of mucosal immune responses in mice with colon cancer following sustained administration of Streptococcus thermophiles. Saudi Journal of Biological Sciences. 2021 May 6.


2 Abdullah S, El Hadad S, Aldahlawi A. In vitro optimization, characterization and anti-tumor evaluation against colorectal cancer of a novel 5-fluorouracil oral nanosuspension using soy protein, polysaccharides-protein complexation, and in-situ gel formation. Journal of Drug Delivery Science and Technology. 2021 Nov 6:102857.


3 Aldahlawi AM, Zaher KS. SPOTLIGHT ON IMMUNITY AGAINST COVID-19 WITH EMPHASIS ON CYTOKINE STORM. Pharmacophore. 2021 Mar 1;12(2).


4 Basingab F, Alghamdi A, Alhazmi S, Alrofaidi A, Alharbi M. The Role of Immune-related NLR Pyrin Domain Containing 2 (NLRP2) Gene in the Development and Diseases. Journal of Pharmaceutical Research International. 2021 Mar 29:10-23.


5 Al-Rahimi JS, Nass NM, Hassoubah SA, Wazqar DY, Alamoudi SA. Levels and predictors of fear and health anxiety during the current outbreak of COVID-19 in immunocompromised and chronic disease patients in Saudi Arabia: A cross-sectional correlational study. Plos one. 2021 Apr 26;16(4):e0250554.


6 Aldahlawi AM, Abdullah ST. Dendritic cell-based immunotherapies and their potential use in colorectal cancer immunotherapy.


7 Alrobai A, Alrahimi J, El Hadad S. An overview of the meningococcal disease and impact of the quadrivalent meningococcal conjugate vaccine. Novel Research in Microbiology Journal. 2021 Dec 7;5(6):1463-79.


8 Alrahimi J, Hassoubah S, Alotaibi N, Abualainin M, Albesher N, Almoubady S. Antimicrobial Activity of Metabolites Extracted from Marine Actinomycetes. Bioscience Biotechnology Research Communications Vol 14 No (4) Oct-Nov-Dec 2021. doi: http://dx.doi.org/10.21786/bbrc/


9 Aldahlawi A, Alhashmi A, Alrahimi J, Hassoubah S, EL Hadad S. IMPACTS OF SACCHAROMYCES ON CD20 AND CD68 MARKERS IN DIABETIC RAT SPLEEN IMMUNIZED WITH INFLUENZA VACCINES. Pharmacophore. 2021 Jan 1;12(1).


10 Abdullah S, El Hadad S, Aldahlawi A. The development of a novel oral 5-Fluorouracil in-situ gelling nanosuspension to potentiate the anticancer activity against colorectal cancer cells. International journal of pharmaceutics. 2021 Dec 27:121406.


11 Basingab F S H, Zaher K S A. Insight to SARS-CoV-2 Vaccines Based on Virus Structure and Properties. Pharmacophore. 2021;12(5):56-68.


Previous Publications

1 Mohammed A. Hassan, Kaltoom Al-Sakkaf, Mohammed Razeeth Shait Mohammed, Ashraf Dallol, Jaudah Al-Maghrabi, Alia Aldahlawi, Sawsan Ashoor, Mabrouka Maamra, Jiannis Ragoussis, Wei Wu, Mohammad Imran Khan, Abdulrahman Al-Malki and Hani Choudhry. 2020. Integration of Transcriptome and Metabolome Provides Unique Insights to Pathways Associated with Obese Breast Cancer Patients. Frontier in oncology (Cancer Metabolism). doi: 10.3389/fonc.2020.00804


2 Sahar El-Hadad, Ayeshah Zakareya, Ahmed Al-Hejin, Alia Aldahlawi, and Mona Alharbi. 2019. Sustaining exposure to high concentration of bifidobacteria inhibit gene expression of mouse mucosal immunity. Heliyon Journal, https://doi.org/10.1016/j.heliyon.2019.e02866.


3 Sahar El-Hadad, Boshra Al-Hazmi, Aawiah Alhebshi, Alia M. Aldahlawi, Reem Al-Bassam. 2019. Lactobacillus-rhamnosus enhance the immunological antitumor effect of 5-fluorourcil against colon cancer. Pakistan Journal of Biological Science. DOI: 10.3923/pjbs.2019.


4 Shiekhah M. Al Zahrani, Ulfat M. Omar, Sawsan A. Rahimulddin, Ayat B. Al-Ghafari, Alia M. Aldahlawi, Huda A. Al Doghaither. Selective antiproliferative and apoptotic effects of the natural alkaline water Zamzam in breast cancer cell line Michigan Cancer Foundation-7. 2019. Journal of Cancer Research and Therapeutics. 15(5): 1098-1104.


5 Khaled Elbanna, Sahar El Hadad, Abdelrahaman Assaeedi, Alia M. Aldahlawi, Manal Khider and Alawiah Alhebshi. 2018. In vitro and in vivo evidences for innate immune stimulators lactic acid bacterial starters isolated from fermented camel dairy products. Scientific Reports, 8:12553. DOI: 10.1038/s41598-018-31006-3.


6 Magda M Aly1, Roqayah H Kadi, Alia M Aldahlawi, Mayson H Alkhatib, Abdulwahab Noor Wali. 2017. Production of the antitumor l-glutaminase enzyme from thermotolerant Streptomyces sp. d214, under submerged fermentation conditions. Journal of Experimental Biology and Agricultural Sciences. 5(6): 878-885. DOI: http://dx.doi.org/10.18006/2017.5 (6). 878.885.


7 Mohamad Nidal Khabaz, Amer Abdelrahman, Nadeem Butt, Lila Damnhory, Mohamed Elshal, Alia M. Aldahlawi, Swsan Ashoor, Basim Al-Maghrabi, Pauline Dobson, Barry Brown, Kaltoom Al-Sakkaf, Mohmmad Al-Qahtani and Jaudah Al-Maghrabi. 2017. Immunohistochemical staining of leptin is associated with grade, stage, lymph node involvement, recurrence, and hormone receptor phenotypes in breast cancer. BMC Women's Health. 17:105 DOI 10.1186/s12905-017-0459-y.


8 Jaudah Al-Maghrabia, Kaltoom Al-Sakkafb, Imtiaz Ahmad Qureshic, Nadeem Shafique Buttd, Lila Damnhoryb, Mohamed Elshale, Basim Al-Maghrabif, Alia M. Aldahlawi, Sawsan Ashoorh, Barry Browni, Pauline Dobsoni, Mohamad Nidal Khabaz .2017. AMPK expression patterns are significantly associated with poor prognosis in breast cancer patients. Annals of Diagnostic Pathology.29: 62-67.


9 Mohamad Nidal Khabaz, Kaltoom Al-Sakkaf, Imtiaz Ahmad Qureshi, Nadeem Shafique Butt, Lila Damnhory, Mohamed Elshal, Basim Al-Maghrabi, Alia M. Aldahlawi, Sawsan Ashoor, Barry Brown, Pauline Dobson, Jaudah Al-Maghrabi .2017. Expression of p-AMPK is associated with hormone receptor phenotypes and lymph node metastasis in breast cancer. Int J Clin Exp Pathol. 10(6): 7044-7051.


10 Saleh A. Mohamed, Mohamed F. Elshal, Taha A. Kumosani, Alia M. Aldahlawi, Tasneem A. Basbrain, Fauziah A. Alshehri, Hani Choudhry. L-asparaginase Isolated from Phaseolus Vulgaris Seeds Exhibited Potent Anti-Acute Lymphoblastic Leukemia Effects In-Vitro and Low Immunogenic Properties In-Vivo. 2016. International Journal of environmental research and public health.13 (10) :(1008) 1-10. DOI: 10.3390/ijerph13101008.


Patents

  • Patent titled “Oral administration of 5-fu in a gelling nanosuspension for targeted delivery to treat colorectal cancers” Participants in in the invention: Dr. Alia Dahlawi, Dr. Jamila Al-Haddad and Dr. Sama Abdullah, in Biology feild from the US Patent Office - 2021
Members

Team Members

Dr. Aliyah Aldahlawi

Head of Unit
2528

Dr. Fatimah Basingab

Researcher
7508

Dr. Jehan Alrehimi

Researcher
7415

Dr. Kulthom Saggaf

Researcher
56714

Prof. Kawthar Zahir

Researcher
64400

Iman Alghamdi

Lab Technician
20318

Education

Training & Students Supervision

Phd. Postgraduate students supervision

Phd. Students
  • Safiah Alzahrani
  • Samaa Abdullah
  • Enayah Abonasor
  • Alaa Alsarhani
  • Aljazi Alrashidi
postgrad
M.Sc postgraduate students supervision

M.Sc Students
  • Afnan Abdulqader
  • Ghada Alsobhi
  • Najlaa Alotaibi
  • Reem Alzahrani
  • Bashair Almahdawi
  • Mahi Yousef
  • Bushar Aljuhani
  • Asmaa Alrobai
  • Hind Baik
postgrad
Graduated Students
  • Shorouq Alharbi
  • Sarah Alqourashi
  • fatimah Alzahrani
  • Sawsan Ahmad
  • Wadha Alshehri
  • Abeer Alhashemi
  • Nada Almarghalani
  • Mohammad Alsaadi
  • Fai Ashgan
  • Lamia Demiati
  • Arwa Zihairi
  • Aysha Zakaryia
  • Iman Alrowaili
  • Rawda Fallata
  • Sahar Almarhabi
  • Hamda Alsaidi
  • Shahad Alsonosi
  • Abdo Abdullah
  • Sheikha Alzahrani
  • Amani Alzahrani
  • Ghaida Bin Seddiq
  • Rawan Abdulwahed
  • Mashael Alotaibi
  • Tasneem Basabrain
  • Fawziah Alshehri
  • Faten Moufti
  • Malak Barasheed
  • Nahed Albelowi
  • Hadeel Alsofiani
  • Maram Hawsawi
  • Safa Seif
  • Nusaiba Anbeisi
  • Maha Alsolami
postgrad
Contact

Contact Us

Kfmrc-miu@kau.edu.sa

00966-12-695-2000 (20318)

King Fahd Medical Research Center

kfmrc@kau.edu.sa

00966-12-695-2000 ext. (25027 ,61453)

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Last Update
8/31/2023 8:58:49 AM