KFMRC
kfmrc@kau.edu.sa
(25027 ,61453) 00966-12-695-2000
وحدة الخلايا الجذعية
تهتم الوحدة بدراسة الإكسوزومات، الخلايا الجذعية السرطانية، الخلايا الجذعية الجنينية والخلايا الجذعية الميزنشيمية وذلك من خلال التعامل مع الخلايا الجذعية وتحويلها إلى خلايا مطلوبة للاستخدام في علاج بعض الأمراض سواء على المستوى التجريبي أو الطبي.
تسعى وحدة الخلايا الجذعية الجنينية إلى دعم واجتذاب الباحثين وطلبة الدراسات العليا في مجال أبحاث الخلايا الجذعية الجنينية حيث تقوم الوحدة بعمل أبحاث في مجال بيولوجية الخلايا الجذعية مهيئة بذلك فرصة دراسية وتدريبية لطلبة الماجستير والدكتوراه.
المجالات البحثية
- علاج السرطان
- التشخيص والعلاجات
- زراعة الخلايا
- المعلوماتية الحيوية
+53
المنشورات العلمية
+2
الأنشطة العلمية
+7
التدريب والتعليم
+2
الشراكات
+21
الطلبة
مخرجات الوحدة
الإنجاز العلمي
المنشورات العلمية لعام 2023
Modulation of the Tumor Microenvironment by Ellagic Acid in
Rat Model for Hepatocellular Carcinoma: A Potential Target
against Hepatic Cancer Stem Cells,
Wafaa S. Ramadan, Saleh Alkarim, Mohammed Moulay, Ghadeer Alrefeai,
Fatma Alkudsy, Khalid Rehman Hakeem and Ashwaq Iskande, Cancers, MDPI
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Yield and Composition Variations of the Milk from Different
Camel Breeds in Saudi Arabia,
Amr A. El-Hanafy, Yasser M. Saad, Saleh A. Alkarim, Hussein A. Almehdar, Fuad M. Alzahrani,
Mohammed A. Almatry, Vladimir N. Uversky and Elrashdy M. Redwan, SCi, MDPI
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Computational Molecular Docking and Simulation-Based Assessment of Anti-Inflammatory Properties of Nyctanthes arbor-tristis Linn Phytochemicals
by Varish Ahmad
, Mohammad Imran Khan
, Qazi Mohammad Sajid Jamal
, Faisal A. Alzahrani
and Raed Albiheyri, MDPI
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25 (S)-Hydroxycholesterol acts as a possible dual enzymatic inhibitor of SARS-CoV-2 Mpro and RdRp–: an insight from molecular docking and dynamics simulation approaches
Faisal A. Alzahrani
, Saleh A. Alkarim
, Yousef M. Hawsawi
, Wesam H. Abdulaal
, Raed Albiheyri
, Bassem Kurdi, Journal of Biomolecular Structure and Dynamics
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Plant-Derived Extracellular Vesicles and Their Exciting Potential as the Future of Next-Generation Drug Delivery
by Faisal A. Alzahrani, Mohammad Imran Khan
, Nader Kameli, Elham Alsahafi
and Yasir Mohamed Riza , MDPI
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Recognition of Differentially Expressed Molecular Signatures and Pathways Associated with COVID-19 Poor Prognosis in Glioblastoma Patients
by Faisal A. Alzahrani, Mohd Faheem Khan and Varish Ahmad, MDPI
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Exosomes from foetal tissue-derived mesenchymal stem cells as a novel product for therapeutic application by Alrefaei Ghadeer |
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Cinnamon and ginger extracts attenuate diabetes-induced inflammatory testicular injury in rats and modulating SIRT1 expression by
Ghadeer I. Alrefaei, Hailah M. Almohaimeed, Sami A. Algaidi, Mohammed Saad Almuhayawi, Fatma Mohamed AbdAllah, Nouf S. Al-Abbas, Nehad A. Shaer, Zuhair M. Mohammedsaleh, Fayez M Saleh and Nasra Ayuob |
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Promoter Methylation-Regulated Differentially Expressed Genes in Breast Cancer by
Samar Sindi, Norah Hamdi, Sabah Hassan, Magdah Ganash, Mona Alharbi,Najla Alburae, Sheren Azhari, Shadi Alkhayyat, Ayman Linjawi, Heba Alkhatabi, Aisha Elaimi, Ghadeer Alrefaei, Nouf Alsubhi, Aziza Alrafiah, and Safiah Alhazmi
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Identification of novel interacts partners of ADAR1 enzyme mediating the oncogenic process in aggressive breast cancer by
Najat Binothman, Majidah Aljadani, Bandar Alghanem, Mohammed Y. Refai, Mamoon Rashid, Abeer Al Tuwaijri, Nouf H. Alsubhi, Ghadeer I. Alrefaei, Muhammad Yasir Khan, Sultan N. Sonbul, Fadwa Aljoud, Sultan Alhayyani, Rwaa H. Abdulal, Magdah Ganash and Anwar M. Hashem
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Effect of Co-culturing both placenta-derived mesenchymal stem cells and their condition medium in the cancer cell (HepG2) migration, damage through apoptosis and cell cycle arrest by Opo, FADM et al |
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Nanoformulated 3'-diindolylmethane modulates apoptosis, migration, and angiogenesis in breast cancer cells by Harakeh S, Akefe IO, Saber SH, Alamri T, Al-Raddadi R, Al-Jaouni S, Tashkandi H, Qari M, Moulay M, Aldahlawi A, Abd Elmageed ZY, Mousa S. Heliyon. 2023 Dec 10;10(1):e23553. doi: 10.1016/j.heliyon.2023.e23553. PMID: 38187226;
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Identification of natural antiviral drug candidates against Tilapia Lake Virus: Computational drug design approaches. by Moulay et al. : PLOS ONE .2023. https://doi.org/10.1371/journal.pone.0287944
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Bacterial Assessment and Isolation of Antibiotic Resistant Bacteria from the Indian Major Carp, Labeo rohita. by Md.ShemulMiana, et al, Volume 22, Issue 6, Page 34-45, 2023; Article no.AJFAR.96839ISSN: 2582-3760 |
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Apoptosis induction in human hepatoma cell line HepG2 cells by trans- Anethole via activation of mitochondria-mediated apoptotic pathways. .Harakeh S, Al-Raddadi R, Alamri T, Al-Jaouni S, Qari M, Qari Y, Kumar A, Tashkandi HM, Moulay M, Aldahlawi AM, Slama P, Haque S. ,Biomed Pharmacother. 2023 Sep;165:115236. doi: 10.1016/j.biopha.2023.115236. Epub 2023 Jul 31. PMID: 37531780. |
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المنشورات العلمية لعام 2022
Impact of nanomaterials on sustainable pretreatment of lignocellulosic biomass for biofuels production: An advanced approach, Neha Srivastava, Rajeev Singh, Manish Srivastava, Akbar Mohammad, Steve Harakeh, Ravindra Pratap Singh, Dan Bahadur Pal, Shafiul Haque, Hossam H. Tayeb, Mohammed Moulay, Vijai Kumar Gupta,
Bioresource Technology
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Effect of Co-culturing both placenta-derived mesenchymal stem cells and their condition medium in the cancer cell (HepG2) migration, damage through apoptosis and cell cycle arrest, F.A. Dain Md Opo, Mohammed Moulay, Ghadeer I. Alrefaei, Nouf H. Alsubhi, Saleh Alkarim, Mohammed M. Rahman, Saudi Journal of Biological Sciences,
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. Pharmacophore-based virtual screening approaches to identify novel molecular candidates against EGFR through comprehensive computational approaches and in-vitro studies. F A Dain Md, Moulay Mohammed, Zari Ali, Alqaderi Afnan, Alkarim Saleh, Zari Talal, Bhuiyan Mohiuddin Ahmed, Mahmoud Maged Mostafa, Aljoud Fadwa, Suhail Mohd, Edris Sherif, Ramadan Wafaa S., Kamal Mohammad Amjad, Nemmiche Saïd, Ahammad Foysal
Frontiers in Pharmacology. V13. 2022
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Enhancement in functional stability of microbial endoglanases produced using paddy straw via treatment with manganese oxide based porous nanocomposite synthesized from mixed fruit waste, Mishra, Hossam H. Tayeb, Mohammed Moulay, Vijai Kumar Gupta, Bioresource Technology,
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Efficacy of the Immobilized Kocuria flava Lipase on Fe3O4/Cellulose Nanocomposite for Biodiesel Production from Cooking Oil Wastes. Najjar, A.A.; Hassan, E.A.; Zabermawi, N.M.; Almasaudi, S.B.; Moulay, M.; Harakeh, S.; Abd El-Aal, M., Catalysts
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Effects of Spinel Ferrite Nanoparticles on Normal Human Blood Serum. Moulay et al.ndian J Pharm Sci
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Epigenetics and Probiotics Application toward the Modulation of Fish Reproductive Performance. Sumon, M.A.A.; Molla, M.H.R.; Hakeem, I.J.; Ahammad, F.; Amran, R.H.; Jamal, M.T.; Gabr, M.H.; Islam, M.S.; Alam, M.T.; Brown, C.L.; Lee, E.-W.; Moulay, M.; Asseri, A.H.; Opo, F.A.D.M.; Alsaiari, A.A.; Hasan, M.T. Fishes
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Stress response induced by cadmium in soybeans (Glycine max L.) and health risk assessment. Houria Tadjouri, Housna Medjedded, Saïd Nemmiche, Rabah Chadli, and Mohammed Moulay. Plant Physiology Reports
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Stem-Cell-Based Therapy: The Celestial Weapon against Neurological Disorders. Mohamed Zayed ,Samar Sultan, Hashem O. Alsaab ,Shimaa Yousof, Ghadeer I. Alrefaei ,Nouf H. Alsubhi ,Saleh Alkarim ,Kholoud S. Al Ghamdi ,Sali Abubaker Bagabir ,Ankit Jana ,Badrah Alghamdi ,Hazem M. Atta,Ghulam Md Ashraf.
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Deciphering the Significance of Plasma Chemokines as Prognostic Biomarkers in Pegylated IFN-Α-2a /Ribavirin-Treated Chronic Hepatitis C Genotype 4 Patients.
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Identification and Characterization of Novel Mutations in Chronic Kidney Disease (CKD) and Autosomal Dominant Polycystic Kidney Disease (ADPKD) in Saudi Subjects by Whole-Exome Sequencing. Alzahrani, Othman R., et al. Medicina
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Camels’ biological fluids contained nanobodies: promising avenue in cancer therapy. Al-Numair, Nouf S., et al. Cancer Cell International
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Pharmacophore-Model-Based Virtual-Screening Approaches Identified Novel Natural Molecular Candidates for Treating Human Neuroblastoma. Opo, FA Dain Md, et al. Current Issues in Molecular Biology
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Epigenetic regulation of inflammation: The metabolomics connection." Seminars in Cell & Developmental Biology. Rath, Suvasmita, et al. Academic Press, 2022.
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Co-Occurrence of β-Lactam and Aminoglycoside Resistance Determinants among Clinical and Environmental Isolates of Klebsiella pneumoniae and Escherichia coli: A Genomic Approach. Altayb, Hisham N., et al. Pharmaceuticals . |
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Whole-Genome Sequence of Multidrug-Resistant Methicillin-Resistant Staphylococcus epidermidis Carrying Biofilm-Associated Genes and a Unique Composite of SCCmec. Altayb, Hisham N., et al. Antibiotics |
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Profiling the effect of targeting wild isocitrate dehydrogenase 1 (IDH1) on the cellular metabolome of leukemic cells. Shait Mohammed, Mohammed Razeeth, et al. International Journal of Molecular Sciences
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The Therapeutic Potential of Milk Extracellular Vesicles on Colorectal Cancer. Babaker, Manal A., et al. International Journal of Molecular Sciences
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Study of oral microbiota diversity among groups of families originally from different countries. Altayb, Hisham N., et al. Saudi Journal of Biological Sciences
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25 (S)-Hydroxycholesterol acts as a possible dual enzymatic inhibitor of SARS-CoV-2 Mpro and RdRp–: an insight from molecular docking and dynamics simulation approaches. Alzahrani, Faisal A., et al. Journal of Biomolecular Structure and Dynamics.
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Genomic Analysis of Multidrug-Resistant Hypervirulent (Hypermucoviscous) Klebsiella pneumoniae Strain Lacking the Hypermucoviscous Regulators (rmpA/rmpA2). Altayb, Hisham N., et al. Antibiotics .
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Toward the Identification of Natural Antiviral Drug Candidates against Merkel Cell Polyomavirus: Computational Drug Design Approaches
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Genetic data sharing and artificial intelligence in the era of personalized medicine based on a cross‐sectional analysis of the Saudi human genome program. Alrefaei, Abdulmajeed F., et al. Scientific reports
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Exosomal miRNAs as a Promising Source of Biomarkers in Colorectal Cancer Progression.Bakhsh, Tahani, et al. International Journal of Molecular Sciences
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المنشورات العلمية لعام 2021
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Anti-Hepatocellular Carcinoma Biomolecules: Molecular Targets Insights. Juaid N, Amin A, Abdalla A, Reese K, Alamri Z, Moulay M, Abdu S, Miled N. International Journal of Molecular Sciences. 2021 Jan;22(19):10774.
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Optimizing the catalytic activities of methanol and thermotolerant Kocuria flava lipases for biodiesel production from cooking oil wastes. Najjar A, Hassan EA, Zabermawi N, Saber SH, Bajrai LH, Almuhayawi MS, Abujamel TS, Almasaudi SB, Azhar LE, Moulay M, Harakeh S. Scientific Reports. 2021 Jul 1;11(1):1-9.
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Phytotoxic evaluation of neonicotinoid imidacloprid and cadmium alone and in combination on tomato (Solanum lycopersicum L.). Touzout N, Mehallah H, Moralent R, Moulay M, Nemmiche S. Ecotoxicology. 2021 Jun 3:1-2.
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المنشورات العلمية السابقة
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Nanoencapsulated dietary polyphenols for cancer prevention and treatment: successes and challenges. Shams Tabrez, Nasimudeen R Jabir, Vaqar Mustafa Adhami, Mohammad Imran Khan, Mohammed Moulay, Mohammad Amjad Kamal & Hasan Mukhtar. NAnomedecine. 2020.
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Exosomes: the crucial element in prostate cancer. Mohammed Moulay, Saleh Alkarim. Chapter 18. Nature. Springer, 2020.
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Interaction of human serum blood with spinel ferrite nanoparticles. Mohammed Moulay, Mohammed S. Aida, Shams Tabrez, Mokhtar Hjiri, and Boubaker Zarrad3 and Salah Al-Karim. Material, science in medicine journal. Under press.
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Gene and Marker Stem Cells Expression in Mouse Thyroid Gland against Age Changes and the Prophylactic Role of Selenium Gene and Marker Stem Cells Expression in Mouse Thyroid Gland against Age Changes and the Prophylactic Role of Selenium . Laila M, Aboul-Mahasen Morsy, Mai M Ashgan and Saleh A AlKarim . Ec clinical and experimental anatomy ,April 10, 2020.
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An Insight of Multitudinous and Inveterate Pharmacological Applications of Foeniculum vulgare (Fennel): Pharmacology and Therapeutic Uses. Fareeduddin Q. Syed, Muqtadir B. Mirza, Ayman I. Elkady, Khalid R. Hakeem and Saleh Alkarim. January 2019. In book: Plant and Human Health, Chapter 11. Volume 3, pp.231-254.
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Disorder in milk proteins: adipophilin and TIP47, important constituents of the milk fat globule membrane. Elrashdy M. Redwan, Saleh A. Alkarim, Amr A. El-Hanafy, Yasser M. Saad, Hussein A. Almehdar & Vladimir N. Uversky. Journal of biomolecular Structure & Dynamics · March 2019.
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Impact of Mothers' Age on Telomere Length and Human Telomerase Reverse Transcriptase Expression in Human Fetal Membrane-Derived Mesenchymal Stem Cells . Ghadeer Alrefai , Hassan S Abduljabbar and Saleh A AlKarim .Stem cells and development 28(24):1632–1645 · December 2019
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Impact of Mothers' Age on Telomere Length and Human Telomerase Reverse Transcriptase Expression in Human Fetal Membrane-Derived Mesenchymal Stem Cells . Ghadeer Alrefai , Hassan S Abduljabbar and Saleh A AlKarim .Stem cells and development 28(24):1632–1645 · December 2019
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Histological and Immunohistochemical Effects of Neuroectodermal Cells Transplantation After Spinal Cord Injury in Rats . Saleh Al-Karim; Wafaa S. Ramadan ; Ghada A. Abdel-Hamid and Fatma Al Qudsi . Int. J. Morphol, 37(1):212-220, 2019.
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Alzahrani, Faisal A. "Melatonin improves therapeutic potential of mesenchymal stem cells-derived exosomes against renal ischemia-reperfusion injury in rats." American journal of translational research 11.5 (2019): 2887.
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المؤتمرات العلمية
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مشاركة بورقة عمل بحثية بعنوان "تقييم العمر على فعالية الخلايا الجذعية الوسيطة المشتقة من الأغشية القاتلة ضد سرطان الكبد العدواني
" في مؤتمر دولي
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مشاركة بعنوان "المشيمة والخلايا الجذعية وسرطان الكبد" القاء
د. محمد مولاي في مؤتمر دبي الدولي للخلايا الجذعية , فبراير 2023
أ.د. صالح الكريم
مشرف الوحدة
25186
أ. نور بن زقر
مساعدة باحث
أ. هوازن العمري
أخصائية مختبر
التعليم
الإشراف الأكاديمي والتدريب
يشرف باحثو الوحدة على رسالة الدكتوراه للطلبة في الأبحاث ذات العلاقة في مجالات الوحدة البحثية
طلبة الدكتوراه
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ابرار الاحمدي
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اشواق اسكندر
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اسحاق خان
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محمد هارون
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وقاص اقبال
يشرف باحثو الوحدة على رسالة الماجستير للطلبة في الأبحاث المتخصصة في المجالات البحثية للوحدة
طلبة الماجستير
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محمد الدخيني
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اوبو
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سارة البلادي
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عبدالعزيز يوسف
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عبدالعزيز الحاتمي
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مي عشقان
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غدير الرفاعي
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ثناء نقلي
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اريج باعقيل
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سوزان الحربي
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سلافة عزوز
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أمل عايض
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منار الحسن
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أشواق اسكندر
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نجوى عبدالعزيز صدرالدين
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غديرمحمد قريشي
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آخر تحديث
11/13/2024 10:14:24 AM
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