KFMRC

kfmrc@kau.edu.sa

(25027 ,61453) 00966-12-695-2000

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وحدة أبحاث علم الأعصاب والشيخوخة

نطاق أبحاث علم الأعصاب والشيخوخة واسع ليشمل جميع الأفكار البحثية الممكنة والتي يمكن أن تساعد في تفسير الحالات الطبية لتلبية الاحتياجات الطبية وإنشاء علاجات أو إجراءات أو تشخيصات طبية جديدة.

تركز أبحاث الوحدة التجريبية على ترجمة الدراسات من سرير المريض إلى طاولة المختبر حيث صممت لفهم وتحسين النتائج الصحية. تهتم وحدة أبحاث علم الأعصاب والشيخوخة كثيراً بالدراسات الفسيولوجية، السلوكية والجزيئية بالإضافة إلى علم الأدوية لتقدير فعالية وسلامة التدخلات العلاجية المختلفة.

المجالات البحثية

  • الدراسات السلوكية مثل الذاكرة والتعلم ، والحسية ، والحركية ، الادمان ، الاكتئاب ، وغير ذلك
  • إنشاء نماذج حيوانية للأمراض والاضطرابات المختلفة: مرض الزهايمر ، التصلب المتعدد ، الألم العضلي الليفي ، الإدمان ، الاكتئاب ، السمنة ، السكتة الدماغية ، الشلل الدماغي.
  • الاضطرابات العصبية للآليات الأساسيّة لأمراض واضطرابات الدماغ والجهاز العصبيّ المركزيّ

+163

المنشورات العلمية

+3

الأنشطة العلمية

+3

الجوائز العلمية

+2

التدريب والتعليم

+2

الشراكات

+29

الطلبة

مخرجات الوحدة

الإنجاز العلمي


المنشورات العلمية لعام 2022

"Ameliorative Effect of Curcumin Nanoparticles against Monosodium Iodoacetate-Induced Knee Osteoarthritis in Rats." Hamdalla, H. M., R. R. Ahmed, S. R. Galaly, I. A. Naguib, B. S. Alghamdi, O. M. Ahmed, A. Farghali and M. Abdul-Hamid .Mediators of Inflammation 2022: 8353472.
1


Comparison of the Treatment Efficacy of Rosuvastatin versus Atorvastatin Loading Prior to Percutaneous Coronary Intervention in ST-Segment Elevation Myocardial Infarction. Adel EM, Elberry AA, Abdel Aziz A, Naguib IA, Alghamdi BS, Hussein RRS. J Clin Med. 2022 Aug 31;11(17):5142. . 2


Effects of Different Lipopolysaccharide Doses on Short- and Long-Term Spatial Memory and Hippocampus Morphology in an Experimental Alzheimer’s Disease Model. Bahaidrah, K.A.; Alzahrani, N.A.; Aldhahri, R.S.; Mansouri, R.A.; Alghamdi, B.S. Clin. Transl. Neurosci. 2022, 6, 20. 3


"Rutin and Quercetin Counter Doxorubicin-Induced Liver Toxicity in Wistar Rats via Their Modulatory Effects on Inflammation, Oxidative Stress, Apoptosis, and Nrf2", Osama M. Ahmed, Mohammed H. Elkomy, Hanaa I. Fahim, Mohamed B. Ashour, Ibrahim A. Naguib, Badrah S. Alghamdi, Heba Uallah R. Mahmoud, Noha A. Ahmed, Oxidative Medicine and Cellular Longevity, vol. 2022, Article ID 2710607, 19 pages, 2022.
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Role of ADMA/DDAH-1 and iNOS/eNOS signaling in the gastroprotective effect of tadalafil against indomethacin-induced gastric injury. Mohamed YT, Naguib IA, Abo-Saif AA, Elkomy MH, Alghamdi BS, Mohamed WR. Biomed Pharmacother. 2022 Jun;150:113026. 5


Investigation of the optimal dose for experimental lipopolysaccharide-induced recognition memory impairment: behavioral and histological studies.Alzahrani NA, Bahaidrah KA, Mansouri RA, Alsufiani HM, Alghamdi BS. J Integr Neurosci. 2022 Mar 21;21(2):49. doi: 10.31083/j.jin2102049. PMID: 35364637
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Exploring the role of Nrf2 signaling in glioblastoma multiforme. Awuah WA, Toufik AR, Yarlagadda R, Mikhailova T, Mehta A, Huang H, Kundu M, Lopes L, Benson S, Mykola L, Vladyslav S, Alexiou A, Alghamdi BS, Hashem AM, Md Ashraf G.Discov Oncol. 2022 Sep 28;13(1):94. PMID: 36169772; PMCID: PMC9519816. 7


The Effect of Melatonin and Exercise on Social Isolation-Related Behavioral Changes in Aged Rats. Alghamdi BS Front. Aging Neurosci. 14:828965. doi: 10.3389/fnagi.2022.828965 8


Psychological Distress During COVID-19 Curfews and Social Distancing in Saudi Arabia: A Cross-Sectional Study. Alghamdi BS, Alatawi Y, Alshehri FS, Tayeb HO, AboTaleb H, Binsalman A. Front Public Health. 2022 Jan 4;9:792533. doi: 10.3389/fpubh.2021.792533. PMID: 35059380; PMCID: PMC8764301. 9


Neuroprotective Potential and Underlying Pharmacological Mechanism of Carvacrol for Alzheimer's and Parkinson's diseases. Javed H, Mohamed Fizur NM, Jha NK, Ashraf GM, Ojha S. Current Neuropharmacology. 2022 Dec. PMID: 36567278 10


Neuroprotective Role of Quercetin against Alpha-Synuclein-Associated Hallmarks in Parkinson's Disease. Das SS, Jha NK, Jha SK, Verma PRP, Ashraf GM, Singh SK. Curr Neuropharmacol. 2022 Dec 21.Epub ahead of print. PMID: 36545726. 11


Recognizing novel drugs against Keap1 in Alzheimer's disease using machine learning grounded computational studies. Mukerjee N, Al-Khafaji K, Maitra S, Suhail Wadi J, Sachdeva P, Ghosh A, Buchade RS, Chaudhari SY, Jadhav SB, Das P, Hasan MM, Rahman MH, Albadrani GM, Altyar AE, Kamel M, Algahtani M, Shinan K, Theyab A, Abdel-Daim MM, Ashraf GM, Rahman MM, Sharma R. Front Mol Neurosci. 2022 Dec 6;15:1036552. PMID: 36561895; PMCID: PMC9764216. 12


A virtual screening investigation to identify bioactive natural compounds as potential inhibitors of cyclin-dependent kinase 9. Atiya A, Shahidi H, Mohammad T, Sharaf SE, Abdulmonem WA, Ashraf GM, Elasbali AM, Alharethi SH, Alhumaydhi FA, Baeesa SS, Rehan M, Shamsi A, Shahwan M. J Biomol Struct Dyn. 2022 Dec 23:1-12. Epub ahead of print. PMID: 36562191. 13


Stem-Cell-Based Therapy: The Celestial Weapon against Neurological Disorders. Zayed MA, Sultan S, Alsaab HO, Yousof SM, Alrefaei GI, Alsubhi NH, Alkarim S, Al Ghamdi KS, Bagabir SA, Jana A, Alghamdi BS, Atta HM, Ashraf GM. Cells. 2022 Nov 2;11(21):3476. doi: 10.3390/cells11213476. PMID: 36359871; PMCID: PMC9655836.
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Role of lisinopril in the therapeutic management of cardiovascular disease by targeting microtubule affinity regulating kinase 4: molecular docking and molecular dynamics simulation approaches.Atiya A, Alsayari A, Bin Muhsinah A, Almaghaslah D, Bilgrami AL, Abdulmonem WA, Alorfi NM, DasGupta D, Ashraf GM, Shamsi A, Shahwan M. J Biomol Struct Dyn. 2022 Nov 14:1-7. Epub ahead of print. PMID: 36376029. 15


Artificial Intelligence in De novo Drug Design: Are We Still There? Curr Top Med Chem.Kumar R, Sharma A, Alexiou A, Ashraf GM. 2022;22(30):2483-2492. PMID: 36263480. 16


TF and TCF4 gene polymorphisms are linked to autism spectrum disorder: a case-control study.Azmerin M, Hussain MS, Aziz MA, Barek MA, Begum M, Sen N, Rahman MA, Shahriar M, Baeesa SS, Ashraf GM, Islam MS. J Int Med Res. 2022 Nov;50(11).PMID: 36448207; PMCID: PMC9716618. 17


Interrelation between extracellular vesicles miRNAs with chronic lung diseases. Dhar R, Mukherjee S, Mukerjee N, Mukherjee D, Devi A, Ashraf GM, Alserihi RF, Tayeb HH, Hashem AM, Alexiou A, Thorate N. J Cell Physiol. 2022 Nov;237(11):4021-4036. doi: 10.1002/jcp.30867. Epub 2022 Sep 5. PMID: 36063496.
18


Anticancer, Cardio-Protective and Anti-Inflammatory Potential of Natural-Sources-Derived Phenolic Acids. Afnan, Saleem A, Akhtar MF, Sharif A, Akhtar B, Siddique R, Ashraf GM, Alghamdi BS, Alharthy SA. Molecules. 2022 Oct 26;27(21):7286. PMID: 36364110; PMCID: PMC9656250. 19


Unveiling the Potential of Polyphenols as Anti-Amyloid Molecules in Alzheimer's Disease. Kabir ER, Chowdhury NM, Yasmin H, Kabir MT, Akter R, Perveen A, Ashraf GM, Akter S, Rahman MH, Sweilam SH.Curr Neuropharmacol. 2022 Oct 10. Epub ahead of print. PMID: 36221865. 20


Desmodin and isopongachromene as potential inhibitors of cyclin-dependent kinase 5: phytoconstituents targeting anticancer and neurological therapy.Atiya A, Batra S, Mohammad T, Alorfi NM, Abdulmonem WA, Alhumaydhi FA, Ashraf GM, Baeesa SS, Elasbali AM, Shahwan M. J Biomol Struct Dyn. 2022 Oct 2:1-11. Epub ahead of print. PMID: 36184739. 21


Treatments against Polymorphosal discrepancies in Glioblastoma Multiforme. Mukerjee N, Maitra S, Roy S, Modak S, Hasan MM, Chakraborty B, Ghosh A, Ghosh A, Kamal MA, Dey A, Ashraf GM, Malik S, Rahman MH, Alghamdi BS, Abuzenadah AM, Alexiou A. Metab Brain Dis. 2023 Jan;38(1):61-68. Epub 2022 Sep 23. PMID: 36149588. 22


Galectins-Potential Therapeutic Targets for Neurodegenerative Disorders. Chaudhary S, Chaudhary S, Rawat S, Kulkarni A, Bilgrami AL, Perveen A, Alghamdi BS, Zughaibi TA, Ashraf GM, Alam MZ, Hussain T.Int J Mol Sci. 2022 Sep 20;23(19):11012.PMID: 36232314; PMCID: PMC9569834. 23


Unravelling Binding of Human Serum Albumin with Galantamine: Spectroscopic, Calorimetric, and Computational Approaches. Ashraf GM, Gupta DD, Alam MZ, Baeesa SS, Alghamdi BS, Anwar F, Alqurashi TMA, Al Abdulmonem W, Alyousef MA, Alhumaydhi FA, Shamsi A.ACS Omega. 2022 Sep 19;7(38):34370-34377. PMID: 36188253; PMCID: PMC9521020. 24


Inflammation-targeted nanomedicine against brain cancer: From design strategies to future developments. Mamun AA, Uddin MS, Perveen A, Jha NK, Alghamdi BS, Jeandet P, Zhang HJ, Ashraf GM. Semin Cancer Biol. 2022 Nov;86(Pt 2):101-116. doi: 10.1016/j.semcancer.2022.08.007. Epub 2022 Sep 6. PMID: 36084815. 25


Drug repurposing against galectin-3 using simulation-based studies. Ashraf GM, Rehan M, Alsayed AO, Somvanshi P, Haque S.J Biomol Struct Dyn. 2022 Oct 2:1-8. Epub ahead of print. PMID: 36184598.
26


Exploring the management approaches of cytokines including viral infection and neuroinflammation for neurological disorders. Mominur Rahman M, Afsana Mim S, Afroza Alam Tumpa M, Taslim Sarker M, Ahmed M, Alghamdi BS, Hafeez A, Alexiou A, Perveen A, Md Ashraf G. Cytokine. 2022 Sep;157:155962. Epub 2022 Jul 16. PMID: 35853395. 27


CRISPR/Cas9 gene editing: New hope for Alzheimer's disease therapeutics. Bhardwaj S, Kesari KK, Rachamalla M, Mani S, Ashraf GM, Jha SK, Kumar P, Ambasta RK, Dureja H, Devkota HP, Gupta G, Chellappan DK, Singh SK, Dua K, Ruokolainen J, Kamal MA, Ojha S, Jha NK. J Adv Res. 2022 Sep;40:207-221. Epub 2021 Jul 6. PMID: 36100328; PMCID: PMC9481950. 28


Mitochondrial Medicine: A Promising Therapeutic Option Against Various Neurodegenerative Disorders. Almikhlafi MA, Karami MM, Jana A, Alqurashi TM, Majrashi M, Alghamdi BS, Ashraf GM. Curr Neuropharmacol. 2022 Aug 30. Epub ahead of print. PMID: 36043795. 29


Impact of Type 2 Diabetes Mellitus with a Focus on Asian Indians Living in India and Abroad: A Systematic Review. Yusufi FNK, Ahmed A, Ahmad J, Alexiou A, Ashraf GM, Yusufi ANK. Endocr Metab Immune Disord Drug Targets. 2022 Aug 27.Epub ahead of print. PMID: 36043735. 30


Cupressus sempervirens L. flavonoids as potent inhibitors to xanthine oxidase: in vitro, molecular docking, ADMET and PASS studies. Linani A, Serseg T, Benarous K, Bou-Salah L, Yousfi M, Alama MN, Ashraf GM. J Biomol Struct Dyn. 2022 Aug 24:1-14.Epub ahead of print. PMID: 36001586. 31


Cytokine storm and neuropathological alterations in patients with neurological manifestations of COVID-19. Tsagkaris C, Bilal M, Aktar I, Aboufandi Y, Tas A, Aborode AT, Suvvari TK, Ahmad S, Shkodina A, Phadke R, Emhamed MS, Baig AA, Alexiou A, Ashraf GM, Kamal MA. Curr Alzheimer Res. 2022 Sep 8.Epub ahead of print. PMID: 36089786.
32


Identification of 11-Hydroxytephrosin and Torosaflavone A as Potential Inhibitors of 3-Phosphoinositide-Dependent Protein Kinase 1 (PDPK1): Toward Anticancer Drug Discovery. Atiya A, Alhumaydhi FA, Sharaf SE, Al Abdulmonem W, Elasbali AM, Al Enazi MM, Shamsi A, Jawaid T, Alghamdi BS, Hashem AM, Ashraf GM, Shahwan M. Biology (Basel). 2022 Aug 18;11(8):1230.PMID: 36009858; PMCID: PMC9405294. 33


Epigenetics of glioblastoma multiforme: From molecular mechanisms to therapeutic approaches. Uddin MS, Mamun AA, Alghamdi BS, Tewari D, Jeandet P, Sarwar MS, Ashraf GM. Semin Cancer Biol. 2022 Aug;83:100-120. doi: 10.1016/j.semcancer.2020.12.015. Epub 2020 Dec 25. PMID: 33370605.
34


Current Trends of Computational Tools in Geriatric Medicine and Frailty Management. Louka AM, Tsagkaris C, Christoforou P, Khan A, Alexiou F, Simou P, Haranas I, Gkigkitzis I, Zouganelis G, Jha NK, Uddin MS, Shen B, Kamal MA, Ashraf GM, Alexiou A.Front Biosci (Landmark Ed). 2022 Jul 29;27(8):232. PMID: 36042184. 35


COVID-19 diagnostic methods in developing countries. Maniruzzaman M, Islam MM, Ali MH, Mukerjee N, Maitra S, Kamal MA, Ghosh A, Castrosanto MA, Alexiou A, Ashraf GM, Tagde P, Rahman MH. Environ Sci Pollut Res Int. 2022 Jul;29(34):51384-51397.Epub 2022 May 27. PMID: 35619009; PMCID: PMC9135468.
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Resveratrol and neuroprotection: an insight into prospective therapeutic approaches against Alzheimer's disease from bench to bedside. Islam F, Nafady MH, Islam MR, Saha S, Rashid S, Akter A, Or-Rashid MH, Akhtar MF, Perveen A, Md Ashraf G, Rahman MH, Hussein Sweilam S. Mol Neurobiol. 2022 Jul;59(7):4384-4404. Epub 2022 May 12. PMID: 35545730. 37


Isolation, characterization and in vitro antioxidant activity screening of pure compound from black pepper (Piper nigrum). Mollik M, Rahman MH, Al-Shaeri M, Ashraf GM, Alexiou A, Gafur MA.Environ Sci Pollut Res Int. 2022 Jul;29(34):52220-52232.Epub 2022 Mar 8. PMID: 35260981.
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Isolation, characterization and in vitro antioxidant activity screening of pure compound from black pepper (Piper nigrum). Mollik M, Rahman MH, Al-Shaeri M, Ashraf GM, Alexiou A, Gafur MA. Environ Sci Pollut Res Int. 2022 Jul;29(34):52220-52232. Epub 2022 Mar 8. PMID: 35260981. 39


Computational insight into the binding of bryostatin 1 with ferritin: implication of natural compounds in Alzheimer's disease therapeutics. Shahwan M, Alhumaydhi FA, Sharaf SE, Alghamdi BS, Baeesa S, Tayeb HO, Ashraf GM, Shamsi A. J Biomol Struct Dyn. 2022 Jul 5:1-11. Epub ahead of print. PMID: 35787781.
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Emerging therapeutic developments in neurodegenerative diseases: A clinical investigation. Kumar D, Md Ashraf G, Bilgrami AL, Imtaiyaz Hassan M. Drug Discov Today. 2022 Oct;27(10):103305.Epub 2022 Jun 18. PMID: 35728774. 41


Cognitive and affective disturbances in patients with Parkinson's disease: Perspectives for classifying of motor/neuropsychiatric subtypes. Shkodina AD, Tarianyk KA, Boiko DI, Zehravi M, Akter S, Md Ashraf G, Rahman MH. Neurosci Lett. 2022 Jun 11;781:136675.Epub 2022 May 6. PMID: 35533819. 42


Microglia in Alzheimer's Disease: A Favorable Cellular Target to Ameliorate Alzheimer's Pathogenesis. Sumsuzzman DM, Uddin MS, Kabir MT, Hasana S, Perveen A, Alanazi IS, Albadrani GM, Abdel-Daim MM, Ashraf GM. Mediators Inflamm. 2022 Jun 2;2022 PMID: 35693110; PMCID: PMC9184163. 43


The Impact of Chronic Unpredictable Mild Stress-Induced Depression on Spatial, Recognition and Reference Memory Tasks in Mice: Behavioral and Histological Study. Alqurashi GK, Hindi EA, Zayed MA, Abd El-Aziz GS, Alturkistani HA, Ibrahim RF, Al-Thepyani MA, Bakhlgi R, Alzahrani NA, Ashraf GM, Alghamdi BS. Behav Sci (Basel). 2022 May 29;12(6):166.PMID: 35735376; PMCID: PMC9219659.
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Ameliorating Effect of Malva neglecta Wallr on Obesity and Diabetes in Wistar Rats: A Mechanistic Study. Akhtar MF, Farooq U, Saleem A, Saleem M, Rahman MH, Ashraf GM. Biomed Res Int. 2022 May 28;2022:2614599.PMID: 35757485; PMCID: PMC9225868. 45


Link of BIN1, CLU, and IDE Gene Polymorphisms with the Susceptibility of Alzheimer's Disease: Evidence from a Meta-analysis. Abdul Aziz M, Md Ashraf G, Safiqul Islam M. Curr Alzheimer Res. 2022;19(4):302-316 PMID: 35546756.
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Ameliorative Effects of Phytomedicines on Alzheimer's Patients. Khandia R, Viswanathan N, Singhal S, Alqahtani T, Almikhlafi MA, Simonov AN, Ashraf GM. Curr Alzheimer Res. 2022;19(6):420-439. PMID: 35692129. 47


CNS depressant activities of Averrhoa carambola leaves extract in thiopental-sodium model of Swiss albino mice: implication for neuro-modulatory properties. Akter, A., Islam, F., Bepary, S. et al. Biologia 77, 1337–1346 (2022) 48


A Literature Review of Traumatic Brain Injury Biomarkers. Ghaith HS, Nawar AA, Gabra MD, Abdelrahman ME, Nafady MH, Bahbah EI, Ebada MA, Ashraf GM, Negida A, Barreto GE.Mol Neurobiol. 2022 Jul;59(7):4141-4158. Epub 2022 Apr 30. PMID: 35499796; PMCID: PMC9167167. 49


5-fluorouracil and curcumin with pectin coating as a treatment regimen for titanium dioxide with dimethylhydrazine-induced colon cancer model. Karthika C, Sureshkumar R, Sajini DV, Ashraf GM, Rahman MH. Environ Sci Pollut Res Int. 2022 Sep;29(42):63202-63215. Epub 2022 Apr 22. PMID: 35459988.
50


Gut Microbiota and Dysbiosis in Alzheimer's Disease: Implications for Pathogenesis and Treatment. Liu S, Gao J, Zhu M, Liu K, Zhang HL. Mol Neurobiol. 2020 Dec;57(12) Epub 2020 Aug 23. PMID: 32829453; PMCID: PMC7541367. 51


Effect of Cliothosa aurivilli on Paclitaxel-induced Peripheral Neuropathy in Experimental Animals. Karmakar, V., Mohammad, F.S., Baeesa, S.S. et al. Mol Neurobiol 59, 2232–2245 (2022)
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Mechanistic insight into the binding between Ferritin and Serotonin: Possible implications in neurodegenerative diseases,Farah Anjum, Moyad Shahwan, Fahad A. Alhumaydhi, Sharaf E. Sharaf, Waleed Al Abdulmonem, Alaa Shafie, Anwar L. Bilgrami, Anas Shamsi, Ghulam Md Ashraf,Journal of Molecular Liquids,Volume 351,2022 53


Circadian rhythm disorder and anxiety as mental health complications in post-COVID-19. Boiko DI, Skrypnikov AM, Shkodina AD, Hasan MM, Ashraf GM, Rahman MH.Environ Sci Pollut Res Int. 2022 Apr;29(19)Epub 2022 Jan 5. PMID: 34988815; PMCID: PMC8730477. 54


Molecular Insights into Therapeutic Potentials of Hybrid Compounds Targeting Alzheimer's Disease. Jana A, Bhattacharjee A, Das SS, Srivastava A, Choudhury A, Bhattacharjee R, De S, Perveen A, Iqbal D, Gupta PK, Jha SK, Ojha S, Singh SK, Ruokolainen J, Jha NK, Kesari KK, Ashraf GM.Mol Neurobiol. 2022 Jun;59(6)Epub 2022 Mar 26. PMID: 35347587; PMCID: PMC9148293. 55


Implications of miR-148a-3p/p35/PTEN signaling in tau hyperphosphorylation and autoregulatory feedforward of Akt/CREB in Alzheimer's disease. Zeng L, Jiang H, Ashraf GM, Liu J, Wang L, Zhao K, Liu M, Li Z, Liu R. Mol Ther Nucleic Acids. 2021 Nov PMID: 35024240; PMCID: PMC8714918. 56


Biochanin A Improves Memory Decline and Brain Pathology in Cuprizone-Induced Mouse Model of Multiple Sclerosis. Aldhahri RS, Alghamdi BS, Alzahrani NA, Bahaidrah KA, Alsufiani HM, Mansouri RA, Ashraf GM. Behav Sci (Basel). 2022 Mar 4 PMID: 35323389; PMCID: PMC8945046. 57


Role of polyphenols in combating Type 2 Diabetes and insulin resistance. Shahwan M, Alhumaydhi F, Ashraf GM, Hasan PMZ, Shamsi A. Int J Biol Macromol. 2022 May 1; Epub 2022 Mar 2. PMID: 35247420. 58


Galectin-3: A Novel Marker for the Prediction of Stroke Incidence and Clinical Prognosis. Sayed A, Munir M, Nabet MS, Alghamdi BS, Ashraf GM, Bahbah EI, Elfil M. Mediators Inflamm. 2022 Mar 1; PMID: 35281427; PMCID: PMC8904909. 59


Re-establishing the comprehension of phytomedicine and nanomedicine in inflammation-mediated cancer signaling. Jha NK, Arfin S, Jha SK, Kar R, Dey A, Gundamaraju R, Ashraf GM, Gupta PK, Dhanasekaran S, Abomughaid MM, Das SS, Singh SK, Dua K, Roychoudhury S, Kumar D, Ruokolainen J, Ojha S, Kesari KK. Semin Cancer Biol. 2022 Nov;86(Pt 2):1086-1104 Epub 2022 Feb 23. PMID: 35218902. 60


Therapeutic Integrity of Microbiome-based Medicines in Neurodegenerative Disorders. Kumar D, Ashraf GM, Hassan MI. Curr Neuropharmacol.PMID: 35156584. 61


Role of Impaired ABC Transporters in Alzheimer’s Disease. In: Md Ashraf, G., Alexiou, A. (eds) Autism Spectrum Disorder and Alzheimer's Disease . Haque, M. et al. (2021).Springer, Singapore. 62


Potential innovation against Alzheimer's disorder: a tricomponent combination of natural antioxidants (vitamin E, quercetin, and basil oil) and the development of its intranasal delivery. Karthika C, Appu AP, Akter R, Rahman MH, Tagde P, Ashraf GM, Abdel-Daim MM, Hassan SSU, Abid A, Bungau S. Environ Sci Pollut Res Int. 2022 Feb;29(8)Epub 2022 Jan 9. PMID: 35000160. 63


Therapeutic promise of carotenoids as antioxidants and anti-inflammatory agents in neurodegenerative disorders. Kabir MT, Rahman MH, Shah M, Jamiruddin MR, Basak D, Al-Harrasi A, Bhatia S, Ashraf GM, Najda A, El-Kott AF, Mohamed HRH, Al-Malky HS, Germoush MO, Altyar AE, Alwafai EB, Ghaboura N, Abdel-Daim MM.Biomed Pharmacother. 2022 Feb; Epub 2022 Jan 4. PMID: 35062074. 64


Citrus limon L. (lemon) seed extract shows neuro-modulatory activity in an in vivo thiopental-sodium sleep model by reducing the sleep onset and enhancing the sleep duration. Rahman MM, Islam F, Parvez A, Azad MAK, Ashraf GM, Ullah MF, Ahmed M. J Integr Neurosci. 2022 Jan 28;21(1) 65


Biological databases and tools for neurological disorders. Usman MB, Ojha S, Jha SK, Chellappan DK, Gupta G, Singh SK, Dua K, Roychoudhury S, Kumar N, Khan FA, Dureja H, Upadhye V, Zacconi F, Prasanna P, Kesari KK, Ashraf GM, Alexiou A, Jha NK. J Integr Neurosci. 2022 Jan 28;21(1) 66


Exploring the Therapeutic Potential of Targeting Purinergic and Orexinergic Receptors in Alcoholic Neuropathy. Madaan P, Behl T, Sehgal A, Singh S, Sharma N, Yadav S, Kaur S, Bhatia S, Al-Harrasi A, Abdellatif AAH, Ashraf GM, Abdel-Daim MM, Dailah HG, Anwer MK, Bungau S.Neurotox Res. 2022 Apr;40(2)Epub 2022 Jan 26. PMID: 35080764. 67


The prognostic value of neutrophil-to-lymphocyte ratio in patients with traumatic brain injury: A systematic review. Ghozy S, El-Qushayri AE, Varney J, Kacimi SEO, Bahbah EI, Morra ME, Shah J, Kallmes KM, Abbas AS, Elfil M, Alghamdi BS, Ashraf G, Alhabbab R, Dmytriw AA. Front Neurol. 2022 Oct 24 PMID: 36353130; PMCID: PMC9638118. 68


Epigallocatechin 3-gallate: From green tea to cancer therapeutics. Alam M, Ali S, Ashraf GM, Bilgrami AL, Yadav DK, Hassan MI. Food Chem. 2022 Jun 15Epub 2022 Jan 11. PMID: 35063850. 69


Drug reprofiling history and potential therapies against Parkinson's disease. Latif K, Ullah A, Shkodina AD, Boiko DI, Rafique Z, Alghamdi BS, Alfaleh MA, Ashraf GM. Front Pharmacol. 2022 Oct 26;13:1028356.PMID: 36386233; PMCID: PMC9643740. 70


The prognostic value of neutrophil-to-lymphocyte ratio in patients with traumatic brain injury: A systematic review. Ghozy S, El-Qushayri AE, Varney J, Kacimi SEO, Bahbah EI, Morra ME, Shah J, Kallmes KM, Abbas AS, Elfil M, Alghamdi BS, Ashraf G, Alhabbab R, Dmytriw AA. Front Neurol. 2022 Oct 24PMID: 36353130; PMCID: PMC9638118. 71


In Vitro and In Vivo Anti-Arthritic Potential of Caralluma tuberculata N. E. Brown. and Its Chemical Characterization. Iftikhar N, Saleem A, Akhtar MF, Abbas G, Shah S, Bibi S, Ashraf GM, Alghamdi BS, Abujamel TS. Molecules. 2022 Sep 26;27(19):6323 PMID: 36234860; PMCID: PMC9572219. 72


Brain augmentation and neuroscience technologies: current applications, challenges, ethics and future prospects. Jangwan NS, Ashraf GM, Ram V, Singh V, Alghamdi BS, Abuzenadah AM, Singh MF. Front Syst Neurosci. 2022 Sep 23;16: PMID: 36211589; PMCID: PMC9538357. 73


Clinical relevance of biomarkers, new therapeutic approaches, and role of post-translational modifications in the pathogenesis of Alzheimer's disease. Mumtaz I, Ayaz MO, Khan MS, Manzoor U, Ganayee MA, Bhat AQ, Dar GH, Alghamdi BS, Hashem AM, Dar MJ, Ashraf GM, Maqbool T. Front Aging Neurosci. 2022 Sep 7;14:PMID: 36158539; PMCID: PMC9490081. 74


"Design and development of low-cost wearable electroencephalograms (eeg) headset," R. Muhammad, A. Ali, M. A. Anwar, T. A. Soomro, O. AlShorman et al., Intelligent Automation & Soft Computing, vol. 35, no.3, pp. 2821–2835, 2023. 75


The fractal viewpoint of tumors and nanoparticles. Alexiou A, Tsagkaris C, Chatzichronis S, Koulouris A, Haranas I, Gkigkitzis I, Zouganelis G, Mukerjee N, Maitra S, Jha NK, Batiha GE, Kamal MA, Nikolaou M, Ashraf GM. Curr Med Chem. 2022 Aug 1.Epub ahead of print. PMID: 35927901. 76


Repurposing food molecules as a potential BACE1 inhibitor for Alzheimer's disease. Mukerjee N, Das A, Jawarkar RD, Maitra S, Das P, Castrosanto MA, Paul S, Samad A, Zaki MEA, Al-Hussain SA, Masand VH, Hasan MM, Bukhari SNA, Perveen A, Alghamdi BS, Alexiou A, Kamal MA, Dey A, Malik S, Bakal RL, Abuzenadah AM, Ghosh A, Md Ashraf G. Front Aging Neurosci. 2022 Aug 22;PMID: 36072483; PMCID: PMC9443073. 77


Involvement of Resveratrol against Brain Cancer: A Combination Strategy with a Pharmaceutical Approach. Karthika C, Najda A, Klepacka J, Zehravi M, Akter R, Akhtar MF, Saleem A, Al-Shaeri M, Mondal B, Ashraf GM, Tagde P, Ramproshad S, Ahmad Z, Khan FS, Rahman MH. Molecules. 2022 Jul 21;27(14)PMID: 35889532; PMCID: PMC9320031. 78


Dietary Alterations in Impaired Mitochondrial Dynamics Due to Neurodegeneration. Ashraf GM, Chatzichronis S, Alexiou A, Firdousi G, Kamal MA, Ganash M. Front Aging Neurosci. 2022 Jul 11;14 PMID: 35898328; PMCID: PMC9310440. 79


Inhibition of Microtubule Affinity Regulating Kinase 4 by Metformin: Exploring the Neuroprotective Potential of Antidiabetic Drug through Spectroscopic and Computational Approaches. Ashraf GM, DasGupta D, Alam MZ, Baeesa SS, Alghamdi BS, Anwar F, Alqurashi TMA, Sharaf SE, Al Abdulmonem W, Alyousef MA, Alhumaydhi FA, Shamsi A. Molecules. 2022 Jul 21;27(14)Erratum in: Molecules. 2023 Jan 06;28(2): PMID: 35889524; PMCID: PMC9320910. 80


Exposure of metal toxicity in Alzheimer's disease: An extensive review. Islam F, Shohag S, Akhter S, Islam MR, Sultana S, Mitra S, Chandran D, Khandaker MU, Ashraf GM, Idris AM, Emran TB, Cavalu S. Front Pharmacol. 2022 Aug 29;13 PMID: 36105221; PMCID: PMC9465172. 81


Codon Usage Bias Correlates With Gene Length in Neurodegeneration Associated Genes. Khandia R, Saeed M, Alharbi AM, Ashraf GM, Greig NH, Kamal MA. Front Neurosci. 2022 Jul 4;16:895607.PMID: 35860292; PMCID: PMC9289476. 82


A Prospective Viewpoint on Neurological Diseases and Their Biomarkers. Zehravi M, Kabir J, Akter R, Malik S, Ashraf GM, Tagde P, Ramproshad S, Mondal B, Rahman MH, Mohan AG, Cavalu S. Molecules. 2022 May 30 PMID: 35684455; PMCID: PMC9182418. 83


Involvement of Phytochemical-Encapsulated Nanoparticles' Interaction with Cellular Signalling in the Amelioration of Benign and Malignant Brain Tumours.Mehan S, Arora N, Bhalla S, Khan A, U Rehman M, Alghamdi BS, Zughaibi TA, Ashraf GM. Molecules. 2022 Jun 1;27(11) PMID: 35684498; PMCID: PMC9182026. 84


Potential Therapeutic Implications of Caffeic Acid in Cancer Signaling: Past, Present, and Future. Alam M, Ashraf GM, Sheikh K, Khan A, Ali S, Ansari MM, Adnan M, Pasupuleti VR, Hassan MI. Front Pharmacol. 2022 Mar 9;13 PMID: 35355732; PMCID: PMC8959753. 85


Bioactive phytoconstituents as potent inhibitors of casein kinase-2: dual implications in cancer and COVID-19 therapeutics. Anjum F, Sulaimani MN, Shafie A, Mohammad T, Ashraf GM, Bilgrami AL, Alhumaydhi FA, Alsagaby SA, Yadav DK, Hassan MI. RSC Adv. 2022 Mar 10;12(13)PMID: 35424745; PMCID: PMC8982221. 86


DeePred-BBB: A Blood Brain Barrier Permeability Prediction Model With Improved Accuracy. Kumar R, Sharma A, Alexiou A, Bilgrami AL, Kamal MA, Ashraf GM.Front Neurosci. 2022 May 3;16 PMID: 35592264; PMCID: PMC9112838. 87


Alzheimer's Disease-Related Psychosis: An Overview of Clinical Manifestations, Pathogenesis, and Current Treatment. Benmelouka AY, Ouerdane Y, Outani O, Alnasser YT, Alghamdi BS, Perveen A, Ashraf GM, Ebada MA. Curr Alzheimer Res. 2022;19(4) PMID: 35440308. 88


Neuroinflammatory Signaling in the Pathogenesis of Alzheimer's Disease. Uddin MS, Kabir MT, Jalouli M, Rahman MA, Jeandet P, Behl T, Alexiou A, Albadrani GM, Abdel-Daim MM, Perveen A, Ashraf GM. Curr Neuropharmacol. 2022;20(1) PMID: 34525932; PMCID: PMC9199559. 89


Survival and prognostic factors in women treated for epithelial ovarian cancer in western region of Saudi Arabia , Khalid H. Sait, Mohammad Z. Alam, Absarul Haque, Hesham K. Sait, Maram K. Sait and Nisreen M. Anfinan Saudi Medical Journal February 2022, 43 90


A novel biallelic variant further delineates PRDX3-related autosomal recessive cerebellar ataxia, Misbahuddin M. Rafeeq, Muhammad Umair, Muhammad Bilal, Alaa Hamed Habib, Ahmed Waqas, Ziaullah M. Sain, Mohammad Zubair Alam & Raja Hussain Ali 91


A novel biallelic variant in the Popeye domain-containing protein 1 (POPDC1) underlies limb girdle muscle dystrophy type 25 , Arif Mahmood 1 , Abdus Samad 2 , Abid Ali Shah 1 , Abdul Wadood 2 , Afnan Alkathiri 3 , Mohammed Ali Alshehri 4 , Mohammad Zubair Alam 5 6 , Taimur Hussain 7 , Pei He 8 , Muhammad Umair 9 10 92


Unravelling Binding of Human Serum Albumin with Galantamine: Spectroscopic, Calorimetric, and Computational Approaches , Ghulam Md Ashraf*, Debarati Das Gupta, Mohammad Zubair Alam, Saleh Salem Baeesa, Badrah S. Alghamdi, Firoz Anwar, Thamer M. A. Alqurashi, Waleed Al Abdulmonem, Mohammed A. Alyousef, Fahad A. Alhumaydhi, and Anas Shamsi 93


Dioxinodehydroeckol: A Potential Neuroprotective Marine Compound Identified by In Silico Screening for the Treatment and Management of Multiple Brain Disorders, Faizan Ahmad, Punya Sachdeva, Bhuvi Sachdeva, Gagandeep Singh, Hemant Soni, Smriti Tandon, Misbahuddin M. Rafeeq, Mohammad Zubair Alam, Hanadi M. Baeissa & Mohammad Khalid 94


Inhibition of Microtubule Affinity Regulating Kinase 4 by Metformin: Exploring the Neuroprotective Potential of Antidiabetic Drug through Spectroscopic and Computational Approaches by Ghulam Md. Ashraf , Debarati DasGupta Mohammad Zubair Alam , Saleh S. Baeesa , Badrah S. Alghamdi , Firoz Anwar , Thamer M. A. Alqurashi , Sharaf E. Sharaf , Waleed Al Abdulmonem , Mohammed A. Alyousef , Fahad A. Alhumaydhi and Anas Shamsi 95


المنشورات العلمية لعام 2021

BrainFD: measuring the intracranial brain volume with fractal dimension.Ashraf GM, Chatzichronis S, Alexiou A, Kyriakopoulos N, Alghamdi BS, Tayeb HO, Alghamdi J, Khan W, Jalal B, Hazem M. Frontiers in Aging Neuroscience. 2021 Nov 26:797.
1


Empagliflozin effectively attenuates olanzapine-induced body weight gain in female Wistar rats.Ashraf GM, Alghamdi BS, Alshehri FS, Alam MZ, Tayeb HO, Tarazi FI. Frontiers in Pharmacology. 2021;12. 2


Standardizing the effective correlated dosage of Olanzapine and Empagliflozin in female Wistar rats.Ashraf GM, Alghamdi BS, Alshehri FS, Alam MZ, Tayeb HO, Tarazi FI. Current Gene Therapy. 2021 Feb 1;21(1):53-9. 3


Tilianin Ameliorates Cognitive Dysfunction and Neuronal Damage in Rats with Vascular Dementia via p-CaMKII/ERK/CREB and ox-CaMKII-Dependent MAPK/NF-κB Pathways.Jiang H, Ashraf GM, Liu M, Zhao K, Wang Y, Wang L, Xing J, Alghamdi BS, Li Z, Liu R. Oxidative medicine and cellular longevity. 2021 Sep 4;2021.
4


Implications of miR-148a-3p/p35/PTEN signaling in tau hyperphosphorylation and autoregulatory feedforward of Akt/CREB in Alzheimer’s disease.Zeng L, Jiang H, Ashraf GM, Liu J, Wang L, Zhao K, Liu M, Li Z, Liu R. Molecular Therapy-Nucleic Acids. 2022 Mar 8;27:256-75. 5


Identification of miRNA and Their Regulatory Effects Induced by Total Flavonoids From Dracocephalum moldavica in the Treatment of Vascular Dementia.Liu M, Shan G, Jiang H, Zeng L, Zhao K, Li Y, Ashraf GM, Li Z, Liu R. Frontiers in Pharmacology. 2021:3525.
6


Endothelin-1 induced global ischaemia in adult zebrafish: A model with novel entity of stroke research.Chavda V, Patel S, Alghamdi BS, Ashraf GM. Journal of Chemical Neuroanatomy. 2021 Dec 1;118:102025. 7


Efonidipine Exerts Cerebroprotective Effect by Down-regulation of TGF-β/SMAD-2-Dependent Signaling Pathway in Diabetic Rats. Rajput R, Chavda V, Patel SS, Barreto GE, Ashraf GM.Journal of Molecular Neuroscience. 2021 May 30:1-3.
8


In silico interactions of statins with cell death-inducing DNA fragmentation factor-like effector A (CIDEA). Barreto GE, Gonzalez J, Reiner Ž, Jamialahmadi T, Echeverria V, Ashraf GM, Sahebkar A. Chemico-Biological Interactions. 2021 May 20:109528. 9


Physicochemical, Interaction & Topological Descriptors vs. hMAO-A Inhibition of Aplysinopsin Analogs: A Boulevard to the Discovery of Semi-synthetic Antidepression Agents.Singla RK, Ashraf GM, Ganash M, Shen B. Current drug metabolism. 2021 Sep 1;22(11):905-15.
10


Identification of new BACE1 inhibitors for treating Alzheimer’s disease. Kushwaha P, Singh V, Somvanshi P, Bhardwaj T, Barreto GE, Ashraf GM, Mishra BN, Chundawat RS, Haque S. Journal of Molecular Modeling. 2021 Feb;27(2):1-5. 11


A Novel Nanoformulation of Ellagic Acid is Promising in Restoring Oxidative Homeostasis in Rat Brains with Alzheimer’s Disease. Harakeh S, Qari MH, Ramadan WS, Al Jaouni SK, Almuhayawi MS, Al Amri T, Ashraf GM, Bharali DJ, Mousa SA.Current Drug Metabolism. 2021.
12


MicroRNA and mRNA profiling of cerebral cortex in a transgenic mouse model of Alzheimer’s disease by RNA sequencing. Zeng L, Jiang HL, Ashraf GM, Li ZR, Liu R. Neural Regeneration Research. 2021 Oct 1;16(10):2099. 13


CRISPR/Cas9 gene editing: New hope for Alzheimer's disease therapeutics. Bhardwaj S, Kesari KK, Rachamalla M, Mani S, Ashraf GM, Jha SK, Kumar P, Ambasta RK, Dureja H, Devkota HP, Gupta G.Journal of Advanced Research. 2021 Jul 6.
14


Natural Products for Neurodegeneration: Regulating Neurotrophic Signals. Uddin MS, Mamun AA, Rahman MM, Jeandet P, Alexiou A, Behl T, Sarwar MS, Sobarzo-Sánchez E, Ashraf GM, Sayed AA, Albadrani GM.Oxidative Medicine and Cellular Longevity. 2021 Jun 22;2021. 15


Neuroinflammatory Signaling in the Pathogenesis of Alzheimer's Disease. Uddin MS, Kabir MT, Jalouli M, Rahman MA, Jeandet P, Behl T, Alexiou A, Albadrani GM, Abdel-Daim MM, Perveen A, Ashraf GM.Current Neuropharmacology. 2021 Aug 26.
16


Antioxidant and Signal-Modulating Effects of Brown Seaweed-Derived Compounds against Oxidative Stress-Associated Pathology. Begum R, Howlader S, Mamun-Or-Rashid AN, Rafiquzzaman SM, Ashraf GM, Albadrani GM, Sayed AA, Peluso I, Abdel-Daim MM, Uddin M. Oxidative Medicine and Cellular Longevity. 2021 Jul 10;2021. 17


New horizons in the treatment of neurological disorders with tailorable gold nanoparticles. Khan M, Bilgrami AL, Rizvi A, Moshahid M. Current drug metabolism. 2021.
18


The Role of Vitamins in Neurodegenerative Disease: An Update. Rai SN, Singh P, Steinbusch HW, Vamanu E, Ashraf G, Singh MP. Biomedicines. 2021 Oct;9(10):1284. 19


Efficacy of calcitonin gene-related peptide (CGRP) receptor blockers in reducing the number of monthly migraine headache days (MHDs): A network meta-analysis of randomized controlled trials.Masoud AT, Hasan MT, Sayed A, Edward HN, Amer AM, Naga AE, Elfil M, Alghamdi BS, Perveen A, Ashraf GM, Bahbah EI. Journal of the Neurological Sciences. 2021 May 21:117505.
20


Peptide Based Therapy for Neurological Disorders. Yadav A, Pandey D, Ashraf GM. Current Protein and Peptide Science. 2021 Sep 1;22(9):656-65. 21


Delineation of Neuroprotective Effects and Possible Benefits of AntioxidantsTherapy for the Treatment of Alzheimer’s Diseases by Targeting Mitochondrial-Derived Reactive Oxygen Species: Bench to Bedside. Walia V, Kaushik D, Mittal V, Kumar K, Verma R, Parashar J, Akter R, Rahman M, Bhatia S, Al-Harrasi A, Karthika C. Molecular neurobiology. 2021 Nov 9:1-24.
22


Promising Strategies of Colloidal Drug Delivery-Based Approaches in Psoriasis Management. Singh S, Sharma N, Behl T, Sarkar BC, Saha HR, Garg K, Singh SK, Arora S, Amran M, Abdellatif AA, Bilgrami AL. Pharmaceutics. 2021 Nov;13(11):1978. 23


Mechanistic insights into the role of serum-glucocorticoid kinase 1 in diabetic nephropathy: A systematic review. Noor S, Mohammad T, Ashraf GM, Farhat J, Bilgrami AL, Eapen MS, Sohal SS, Yadav DK, Hassan MI. International Journal of Biological Macromolecules. 2021 Dec 15;193:562-73.
24


Deciphering the Interacting Mechanisms of Circadian Disruption and Alzheimer’s Disease. Uddin MS, Sumsuzzman DM, Jeandet P, Behl T, Rauf A, Amran MS, Ashraf GM. Neurochemical Research. 2021 Apr 19:1-5. 25


Exploring the role of monoamine oxidase activity in aging and alzheimer’s disease. Rahman M, Uddin M, Samsuzzaman M, Behl T, Hafeez A, Perveen A, Barreto GE.Current Pharmaceutical Design. 2021.
26


Recent advances in synaptosomal proteomics in Alzheimer’s disease. Ahmad F, Haque S, Chavda V, Ashraf GM. Current Protein and Peptide Science. 2021 Jun 1;22(6):479-92. 27


Impaired Quality Control of Mitochondria Underlying the Pathogenesis of Alzheimer's Disease. Uddin MS, Katha UT, Ashraf GM. Current Drug Targets. 2021 Mar 8.
28


Epigenetics of glioblastoma multiforme: from molecular mechanisms to therapeutic approaches. Uddin MS, Al Mamun A, Alghamdi BS, Tewari D, Jeandet P, Sarwar MS, Ashraf GM. InSeminars in Cancer Biology 2020 Dec 25. Academic Press. 29


Exploring the Anti-Neuroinflammatory Potential of Steroid and Terpenoid-Derived Phytochemicals to Combat Alzheimer's Disease. Kabir M, Uddin M, Zaman S, Rahman M, Behl T, Ahmad A, Hafeez A, Perveen A, Ashraf GM. Current Pharmaceutical Design. 2021.
30


Suicide and suicide attempts in the elderly patients: an epidemiological analysis of risk factors and prevention. Makara-Studzińska M, Somasundaram SG, Halicka J, Madej A, Leszek J, Rehan M, Ashraf GM, Gavryushova LV, Nikolenko VN, Mikhaleva LM, Muresanu C.Current pharmaceutical design. 2021. 31


Deciphering the Role of Nanoparticle-Based Treatment for Parkinson’s Disease. Moni M, Rahman M, Begum M, Uddin M, Ashraf GM. Current Drug Metabolism. 2021.
32


Synaptotagmin-1: A Multi-Functional Protein that Mediates Vesicle Docking, Priming, and Fusion. Ullah N, Maaiden EE, Uddin M, Ashraf GM. Current Protein and Peptide Science. 2021 Jun 1;22(6):470-8. 33


Neurotoxic Aβ: Linking Extracellular and Intracellular Aβ in Alzheimer's Disease. Uddin MS, Al Mamun A, Ashraf GM. Current Protein & Peptide Science. 2021 Jan 22.
34


Exploring the Role of CLU in the Pathogenesis of Alzheimer’s Disease. Uddin M, Kabir M, Begum M, Islam M, Behl T, Ashraf GM. Neurotoxicity research. 2021 Dec;39(6):2108-19. 35


Nano-Neurotherapeutics (NNTs): An Emergent and Multifaceted Tool for CNS Disorders. Sharma A, Manchanda R, Pottoo FH, Ashraf GM. Current Drug Metabolism. 2021.
36


Dissecting Sex-related cognition between Alzheimer’s disease and diabetes: from molecular mechanisms to potential therapeutic strategies. Ashraf GM, Ebada MA, Suhail M, Ali A, Uddin M, Bilgrami AL, Perveen A, Husain A, Tarique M, Hafeez A, Alexiou A. Oxidative Medicine and Cellular Longevity. 2021 Mar 5;2021. 37


Challenges of Gene Therapy for Neurodegenerative Disorders. Uddin MS, Khan ZA, Sumsuzzman DM, Perveen A, Ashraf GM, Puranik N, Yadav D, Chauhan PS, Kwak M, Jin JO. Current Gene Therapy. 2021 Jan 1;21(1):3-10.
38


Neural Stem Cell-Based Therapies and Glioblastoma Management: Current Evidence and Clinical Challenges. Benmelouka AY, Munir M, Sayed A, Attia MS, Ali MM, Negida A, Alghamdi BS, Kamal MA, Barreto GE, Ashraf GM, Meshref M. International Journal of Molecular Sciences. 2021 Jan;22(5):2258. 39


Sleep Disturbances and Cognitive Impairment in the Course of Type 2 Diabetes-A Possible Link. Brzecka A, Madetko N, Nikolenko VN, Ashraf GM, Ejma M, Leszek J, Daroszewski C, Sarul K, Mikhaleva LM, Somasundaram SG, Kirkland CE. Current neuropharmacology. 2021 Jan 1;19(1):78-91.
40


Anti-neuroinflammatory potential of polyphenols by inhibiting NF-κB to halt Alzheimer's disease. Uddin MS, Hasana S, Ahmad J, Hossain M, Rahman M, Behl T, Rauf A, Ahmad A, Hafeez A, Perveen A, Ashraf GM. Current Pharmaceutical Design. 2021 Jan 1;27(3):402-14. 41


Exploring potential of alkaloidal phytochemicals targeting neuroinflammatory signaling of Alzheimer's disease. Uddin MS, Kabir M, Al Mamun A, Behl T, Mansouri RA, Aloqbi AA, Perveen A, Hafeez A, Ashraf GM. Current pharmaceutical design. 2021 Jan 1;27(3):357-66.
42


Molecular mechanisms of metal toxicity in the pathogenesis of Alzheimer’s disease. Kabir MT, Uddin MS, Zaman S, Begum Y, Ashraf GM, Bin-Jumah MN, Bungau SG, Mousa SA, Abdel-Daim MM. Molecular Neurobiology. 2021 Jan;58(1):1-20. 43


Molecular Genetics of Early-and Late-Onset Alzheimer’s Disease. Uddin MS, Hasana S, Hossain M, Islam M, Behl T, Perveen A, Hafeez A, Ashraf GM.Current Gene Therapy. 2021 Feb 1;21(1):43-52.
44


Exploring the new horizon of AdipoQ in obesity-related Alzheimer’s dementia. Uddin M, Rahman M, Sufian MA, Jeandet P, Ashraf GM, Bin-Jumah MN, Mousa SA, Abdel-Daim MM, Akhtar MF, Saleem A, Amran M. Frontiers in Physiology. 2021 Jan 27;11:1828. 45


Multi-target drug candidates for multifactorial Alzheimer’s disease: AChE and NMDAR as molecular targets. Uddin MS, Al Mamun A, Kabir MT, Ashraf GM, Bin-Jumah MN, Abdel-Daim MM. Molecular Neurobiology. 2021 Jan;58(1):281-303.
46


Melatonin attenuates morphine‐induced conditioned place preference in Wistar rats. Alshehri FS, Alghamdi BS, Hakami AY, Alshehri AA, Althobaiti YS. Brain and Behavior. 2021 Dec 1:e2397. 47


Depression, anxiety and stress in Saudi migraine patients using DASS-21: local population-based cross-sectional survey. Al-Hayani M, AboTaleb H, Bazi A, Alghamdi B. International Journal of Neuroscience. 2021 Mar 30:1-9.
48


Effects of melatonin and resveratrol on recognition memory and passive avoidance performance in a mouse model of Alzheimer’s disease. Labban S, Alghamdi BS, Alshehri FS, Kurdi M. Behavioural Brain Research. 2021 Mar 26;402:113100. 49


Migraine-related Disabilities Among Saudi Migraine Patients and its Association with Social Factors. AboTaleb HA, Al-Hayani MM, Alghamdi BS. Archives of Neuroscience. 2021 Jan 31;8(1).
50


Melatonin Blocks Morphine-Induced Place Preference: Involvement of GLT-1, NF-κB, BDNF, and CREB in the Nucleus Accumbens. Alghamdi BS, Alshehri FS. Frontiers in Behavioral Neuroscience. 2021;15. 51


Melatonin Improves Short-Term Spatial Memory in a Mouse Model of Alzheimer’s Disease. Labban S, Alshehri FS, Kurdi M, Alatawi Y, Alghamdi BS. Degenerative Neurological and Neuromuscular Disease. 2021;11:15.
52


Relationship Between Public Mental Health and Immune Status During the COVID-19 Pandemic: Cross-Sectional Data from Saudi Arabia. Alghamdi BS, Alatawi Y, Alshehri FS, Tayeb HO, Tarazi FI. Risk Management and Healthcare Policy. 2021;14:1439. 53


Globular glial tauopathy, a newly recognized white matter tauopathy, with depression/anxiety disorder: report and review of classification. Kurdi M, Alghamdi BS, Parfitt J, Ang LC. Folia Neuropathologica. 2021 Jan 1;59(1).
54


Psychological distress during COVID-19 curfews and social distancing in Saudi Arabia: a cross-sectional study.Alghamdi BS, AlAtawi Y, AlShehri FS, Tayeb HO, Taleb HA, Binsalman A. 55


Molecular Characterization of Integrons and Their Association with Antibiotic Resistance in Acinetobacter baumannii Isolated from Hospitals in Jeddah. Alam MZ. Applied Biochemistry and Microbiology. 2021 Dec;57(1):S64-70.
56


الجوائز العلمية


  • أعلى 2٪ من العلماء على مستوى العالم في العلوم البيولوجية ، أكتوبر 2021- Elsevier BV (Baas et al., 2021)

  • جائزة الخبير العالمي (أعلى 0.031٪) (المرتبة الأولى في المملكة العربية السعودية ، والمرتبة 11 في آسيا ، والمرتبة 52 على مستوى العالم) في مرض الزهايمر ، سبتمبر 2021 ، Expertscape

  • جائزة الخبير العالمي (أعلى 0.0033٪) (المرتبة الأولى في المملكة العربية السعودية ، والرابعة في آسيا ، والثالث عشر عالميًا) في أمراض الجهاز العصبي ، سبتمبر 2021 ، Expertcape

المؤتمرات العلمية


  • حضور مؤتمر دولي بعنوان قمة لانسيت "الوقاية من الأعراض السابقة للمرض وعلاج الأمراض التنكسية العصبية", ديسمبر 2021

  • مشاركة في المؤتمر السادس للجنة الشرق الأوسط وشمال أفريقيا للبحوث والعلاج في التصلب المتعدد (MENACTRIMS) بعنوان "عمل المركبات المضادة للالتهابات على تحسين الحركة وسلوكيات القلق في نموذج Cuprizone Mouse للتصلب المتعدد" , ديسمبر 2021

الأعضاء

فريق العمل

 
أ.د. بدرة الغامدي

مشرفة الوحدة

د. محمد زبير

باحث

د. عبدالله الديري

باحث

د. نوال حلمي

باحثة

د. سحر مليباري

باحثة

د. عماد هندي

باحث

د. مرفت حلواني

باحثة

التعليم

الإشراف الأكاديمي والتدريب

يشرف باحثو الوحدة على رسالة الدكتوراه للطلبة في الأبحاث ذات العلاقة في مجالات الوحدة البحثية

طلبة الدكتوراه

  • خلود العتيبي
  • سماح لبان
  • رشا الدربي
  • بلسم صوفي
  • صالحه القرني
  • منى الذيبياني
postgrad
يشرف باحثو الوحدة على رسالة الماجستير للطلبة في الأبحاث المتخصصة في المجالات البحثية للوحدة

طلبة الماجستير

  • وداد حكمي
  • رهف الظاهري
  • نور الزهراني
  • خلود باحيدرة
  • غفران القرشي
  • خلود اليامي
  • غادة الشهراني
  • حنين أبوطالب
postgrad
يشرف باحثو الوحدة على المشاريع البحثية للطلبة في المجالات البحثية المتعلقة في مجالات الوحدة البحثية

طلبة البكالوريوس

  • عبدالرحمن الحربي
  • أحمد الفي
  • ثامر الفدا
  • زايد العتيبي
  • فيصل باعثمان
postgrad
التواصل

اتصل بنا

kfmrc-pcru@kau.edu.sa


آخر تحديث
10/9/2023 9:57:47 AM