kfmrc@kau.edu.sa
00966-12-695-2000 Ext. (25027 ,61453)
Regenerative Medicine Unit
The unit is divided into two groups: Cancer biology and therapeutics and a regenerative medicine. Cancer biology and therapeutics and a regenerative medicine are sub-groups of the unit interested in how cancer develops and progresses through understanding the mechanisms underlying key processes such as cell growth, tumour metabolism, and tumour immunity.
The unit is also interested in the study of cancer stem cells; a small population of cells characterised by self-renew ability to replenish the growing cancer and resistance to therapeutics such as chemotherapy. The regenerative medicine is focused on regenerative medicine and tissue engineering technology for the modelling and treatment of chronic diseases.
Research Areas
- Cardiovascular diseases.
- Cancer cells.
- Metabolism.
- Tumour.
+39
Publications
+5
Scientific Activities
+2
Scientific Awards & Patents
+27
Education and Training
+7
Partnerships & Consultations
+50
Students
Research Output
Scientific Acheivemnets
2023 Publications
| 1 |
Current status and vision of local pharmaceutical industries in Saudi Arabia: The focus on nanomedicines by Abdulrahman A. Halwani, Bander Balkhi, Abdullah A. Alamoudi, Nada H. Almozain, Areej M. Alajmi, Abdulwahab Noorwali, Moutaz Y. Badr, Ahmad O. Noor, Alaa Bagalagel, Essam A. Tawfik
,Saudi Pharmaceutical Journal
Volume 31, Issue 8, August 2023, 101674
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| 2 |
Association between laboratory markers and Covid-19 disease severity and outcome: a retrospective cohort study in Saudi Arabia by
Aliaa Amr Alamoudi, Sahar Eldakhakhny, Haneen Banjar, Ghada Ajabnoor, Sama Badr Aljohani, Rasha Ramadan Basheer, Basmah Eldakhakhny, Mazen Badawi, Ayman Elsamanoudy
, Front. Immunol., 11 July 2023
Sec. Viral Immunology
Volume 14 - 2023
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| 3 |
In silico Screening and Validation of Achyranthes aspera as a Potential Inhibitor of BRAF and NRAS in Controlling Thyroid Cancer,
Author(s): Ahmad M. Alamri, Faris A. Alkhilaiwi, Najeeb U. Khan and Munazzah Tasleem
Volume 23, Issue 19, 2023
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| 4 |
In vitro studies on the pharmacological potential, anti-tumor, antimicrobial, and acetylcholinesterase inhibitory activity of marine-derived Bacillus velezensis AG6 exopolysaccharide† Check for updates by
Maha A. Alharbi,a Amani A. Alrehaili, Mona Othman I. Albureikan, Amal F. Gharib, Hussam Daghistani, Maha M. Bakhuraysah, Ghfren S. Aloraini, Mohammed A. Bazuhair, Hayaa M. Alhuthalib and Ahmed Ghareeb
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| 5 |
Urolithin A's Antioxidative, Anti-Inflammatory, and Antiapoptotic Activities Mitigate Doxorubicin-Induced Liver Injury in Wistar Rats by
Shahid Karim, Batoul Madani, Abdulhadi S Burzangi, Mohammed Alsieni, Mohammed A Bazuhair, Maha Jamal, Hussam Daghistani, Mohammed O Barasheed, Huda Alkreathy, Mohammad Ahmed Khan, Lateef M Khan
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| 6 |
CRISPR/Cas-based Aptasensor as an Innovative Sensing Approaches for Food Safety Analysis: Recent Progresses and New Horizons by
Marwah Suliman Maashi
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| 7 |
Metformin Anti-Tumor Effect and Metabolic Reprogramming in Breast Cancer Cells
by Feryal Alharthy, Aliaa Amr Alamoudi, Amina Alnouri, Arwa Alkhuzaee, Ghada Ajabnoor, Mehal AlQriqri, Hoda Gad, Hani Choudhry, Alia Aldahlawi, Rasha Ramadan Basheer
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| 8 |
Identification of novel interacts partners of ADAR1 enzyme mediating the oncogenic process in aggressive breast cancer
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| 9 |
Identification of key claudin genes associated with survival prognosis and diagnosis in colon cancer through integrated bioinformatic analysis by
Rana A. Alghamdi and Maryam H. Al-Zahrani
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| 10 |
Preparation and characterization of dextran-zein-curcumin nanoconjugate for enhancement of curcumin bioactivity by
N. T. S. Albogamy, Samia F. Aboushoushah, F. Aljoud, H. Organji & Nihal S. Elbialy
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| 11 |
SOX9 Expression Is Increased in Alzheimer’s Disease (AD) and Is Associated With Disease Progression and APOE4 Genotype: A Computational Approach
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| 12 |
Evaluation of Cytotoxicity of the Methanolic Extract of Red Sea Marine Sponge Xestospongia Testudinaria and Its Related Compounds Against MCF-7 Human Breast Cancer Cells by
Alkhilaiwi FA , Fadil SA , Aljoud FA, Yonbawi AR, Ashi A , Hareeri RH, Bakhashab S , Alamri AM, Albikairi AY, Shaala LA , El-Gamal AA, Youssef DT
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| 13 |
Effect of Nk-lysin peptides on bacterial growth, MIC, antimicrobial resistance, and viral activities
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2022 Publications
| 1 |
Detection of HPV RNA in Extracellular Vesicles from Neuroendocrine Cervical Cancer Cells
by Faris Alkhilaiwi and Hang Yuan
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| 2 |
Era of Molecular Diagnostics Techniques before and after the COVID-19 Pandemic
by Ahmad M. Alamri
, Faris A. Alkhilaiwi
and Najeeb Ullah Khan
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| 3 |
The Therapeutic Potential of Milk Extracellular Vesicles on Colorectal Cancer
by Manal A. Babaker
, Fadwa A. Aljoud
, Faris Alkhilaiwi
, Abdulrahman Algarni
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| 4 |
Evaluation of participation and performance indicators in a breast cancer screening program in Saudi Arabia
Yasser M. Alatawi, Hala A. Alshomrani, Sara M. Baeshen, Hayat H. Alkhamisi, Roaa M. Almazrui, Mohammed S. Alghamdi, Sara M. Bugshan, Tarik K. Alafif, Hussam A. Hijazi, Jawaher R. Alahmadi, Sawsan A. Ashoor, Ahmad M. Alamri and Faris Alkhilaiwi
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| 5 |
Pharmacophore-based virtual screening approaches to identify novel molecular candidates against EGFR through comprehensive computational approaches and in-vitro studies
. F A Dain Md Opo1,Mohammed Moulay, Ali Zari1, Afnan Alqaderi1, Saleh Alkarim1, Talal Zari1, Mohiuddin Ahmed Bhuiyan, Maged Mostafa Mahmoud, Fadwa Aljoud1, Mohd Suhail, Sherif Edris1, Wafaa S. Ramadan, Mohammad Amjad Kamal, Saïd Nemmiche and Foysal Ahammad1
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| 6 |
Carbon Nanoparticles Extracted from Date Palm Fronds for Fluorescence Bioimaging: In Vitro Study
by Shaik Muhammad U. G. Mohiuddin
, Abdu Saeed
, Ahmed Alshahrie
, Adnan Memić
, Fadwa Aljoud
, Shittu Abdullahi
, Hussam A. Organji
and Numan Salah
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| 7 |
Anticancer activity of chicken cathelicidin peptides against different types of cancer
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| 8 |
Investigation of the tris(8-hydroxyquinoline) aluminum as a promising fluorescent optical material for in vitro bioimaging
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| 9 |
The influence of antioxidant dietary-derived polyphenolic combination on breast cancer: Molecular study
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| 10 |
Green synthesis and anticancer activity of silver nanoparticles prepared using fruit extract of Azadirachta indica
. Njud S. Alharbi , Nehad S. Alsubhi.
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| 11 |
Stem-Cell-Based Therapy: The Celestial Weapon against Neurological Disorders
by Mohamed A. Zayed
, Samar Sultan
, Hashem O. Alsaab
, Shimaa Mohammad Yousof
, Ghadeer I. Alrefaei
, Nouf H. Alsubhi
, Saleh Alkarim
, Kholoud S. Al Ghamdi
, Sali Abubaker Bagabir
, Ankit Jana
, Badrah S. Alghamdi
, Hazem M. Atta
and Ghulam Md Ashraf
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| 12 |
Nicaraven-loaded electrospun wound dressings promote diabetic wound healing via proangiogenic and immunomodulatory functions: a preclinical investigation
. Marwah Suliman Maashi, Shatha G. Felemban, Hibah Ali Almasmoum & Mostafa Jarahian
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2021 Publications
| 1 |
Conditionally Reprogrammed Cells and Robotic High-Throughput Screening for Precision Cancer Therapy. Alkhilaiwi F. Frontiers in Oncology. 2021:4191.
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| 2 |
Why do cancer cells break from host circadian rhythm? Insights from unicellular organisms. Alamoudi AA. BioEssays. 2021 Apr;43(4):2000205.
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| 3 |
Colossolactone-G synergizes the anticancer properties of 5-fluorouracil and gemcitabine against colorectal cancer cells. Algehani RA, Abou Khouzam R, Hegazy GA, Alamoudi AA, El-Halawany AM, El Dine RS, Ajabnoor GA, Al-Abbasi FA, Baghdadi MA, Elsayed I, Hattori M. Biomedicine & Pharmacotherapy. 2021 Aug 1;140:111730.
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| 4 |
MSCs and their exosomes: a rapidly evolving approach in the context of cutaneous wounds therapy. Marofi F, Alexandrovna KI, Margiana R, Bahramali M, Suksatan W, Abdelbasset WK, Chupradit S, Nasimi M, Maashi MS. Stem Cell Research & Therapy. 2021 Dec;12(1):1-20.
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| 5 |
Cloning and Embryo Splitting in Mammalians: Brief History, Methods, and Achievements. Rahbaran M, Razeghian E, Maashi MS, Jalil AT, Widjaja G, Thangavelu L, Kuznetsova MY, Nasirmoghadas P, Heidari F, Marofi F, Jarahian M. Stem Cells International. 2021 Nov 30;2021. |
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| 6 |
Re-Expression of Poly/Oligo-Sialylated Adhesion Molecules on the Surface of Tumor Cells Disrupts Their Interaction with Immune-Effector Cells and Contributes to Pathophysiological Immune Escape. Jarahian M, Marofi F, Maashi MS, Ghaebi M, Khezri A, Berger MR.Cancers. 2021 Jan;13(20):5203.
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| 7 |
Formulating etoposide in a nanoemulsion containing polyunsaturated fatty acids potentiates its anti-proliferation and anti-invasion activities against the ovarian cancer cells. Alkhatib MH, Al-Hashemi SM, Gashlan HM. Biocell. 2021;45(3):695.
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| 8 |
Inhibition of Colon Cancer Cells Proliferation and Invasion by Etoposide Loaded on Nano-Suspensions Containing Black Currant Seed and Evening Primrose Oils
, Salwa M Al-Hashemi, Mayson H Alkhatib* and Hana Mohamed Ahmmed Gashlan
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Previous Publications
| 1 |
bashmail, h.a.; alamoudi, a.a.; noorwali, a.; hegazy, g.a.; ajabnoor, g.m.; al-abd, a.m. thymoquinone enhances paclitaxel anti-breast cancer activity via inhibiting tumor-associated stem cells despite apparent mathematical antagonism. molecules2020, 25, 426.
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| 2 |
Mayson H. Alkhatib, ShazaA. Alyamani, Faiza Abdu ‘Incorporation of methotrexate into coconut oil nanoemulsion potentiates its antiproliferation activity and attenuates its oxidative stress’, Drug Delivery, 2020; 27(1): 422 - 430. https://doi.org/10.1080/10717544.2020.1736209. (Indexed in Web of Science, Impact Factor: 4.902).
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| 3 |
Mayson H. Alkhatib, Sahar M. AlMotwaa, Huda M. Alkreathy ‘Incorporation of ifosfamide into various essential oils –based nanoemulsions ameliorates its apoptotic effect in the cancers cells’, Scientific Reports, 2019; 9: 695-705 (Indexed in Web of Science, Impact Factor: 4.122).
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| 4 |
Alrdahe S, Al Sadoun H, Torbica T, et al. Dysregulation of macrophage development and phenotype in diabetic human macrophages can be rescued by Hoxa3 protein transduction. PLoS One. 2019;14(10):e0223980. Published 2019 Oct 18
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| 5 |
waad a. al-otaibi, mayson h. alkhatib, abdulwahab noor wali ‘cytotoxicity and apoptosis enhancement in breast and cervical cancer cells upon coadministration of mitomycin c and essential oils in nanoemulsions formulations’, biomedicine & pharmacotherapy, 2018; 106: 946 – 955 (indexed in web of science isi- impact factor: 3.457).
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| 6 |
bashmail, h. a., alamoudi, a. a., noorwali, a., et al. 2018. thymoquinone synergizes gemcitabine anti-breast cancer activity via modulating its apoptotic and autophagic activities. sci rep, 8, 11674.
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Scientific Conferences
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Participation entitled"Claudin Genes: Prognostic and Diagnostic Significance in Colon Cancer via Integrated Bioinformatics" in the International Cancer Genome Conference, Germany, 15-17 November 2023.
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Scientific paper entitled
"Evaluation of serum biomarkers after intra-articular injection of rat bone marrow-containing mesenchymal stem cells in a rat model of knee osteoarthritis"
At the 7th Congress of Stem Cells and Regenerative Medicine- June 2022
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Presentation entitled
"Topotecan-carvacrol combination therapy presented by sesame oil based nanoemulsion as a novel approach in the treatment of cancer"
In a Three-Minute Message Forum (3TM)- November 2021
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Scientific poster entitled
"Evaluation of induction of apoptosis by active hexose-related complex (AHCC)"
At the Third International Symposium on Clinical Chemistry Laboratory Medicine - November-December 2021
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Scientific poster entitled
"In vitro effect of chicken cathelicidin peptides on human innate and adaptive antitumor immunity"
At the Laboratory and Diagnostics Conference by the Saudi Society for Clinical Laboratory Sciences - January 2021
Scientific Awards
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Second Best Poster Abstract Award
Entitled "Evaluation of Induction of Apoptosis by Active Hexose-Linked Compound (AHCC)"
From the Saudi Society of Clinical Chemistry - December 2021
Patents
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Patent in the treatment of cancer entitled
"Chicken cathelicidins as a cure for cancer"
- The co-inventors: Prof. Abdul Wahab Nour Wali and Dr. Fadwa Al-Joud
From US Patents in November 2021
Dr. Aliaa Alamoudi
Head of Unit
23463
Prof. Abulwahab Nour Wali
Researcher
Dr. Hosam Daghustani
Researcher
Dr. Yousef Almaghrabi
Researcher
Dr. Faris Alkhilaiwi
Researcher
Dr. Samr Sultan
Researcher
Dr. Marwa Almouashi
Researcher
Dr. Rana Alghamdi
Researcher
Dr. Sana Fadil
Researcher
Dr. Abrar Ashi
Researcher
Mehal Algeraigari
Lab Specialist
25674
Education
Training & Students Supervision
Phd. Postgraduate students supervision
Phd. Students
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Seitah Almotairi
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Nehad Alsubhi
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Afnan Felimban
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Manal Babaker
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Iman Ateiah
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Ohoud Alomari
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Nuha Aljuhani
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Hanaa Albeladi
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Hawazen Bin Melih
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Noura Albogamy
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Abdu mohammad
M.Sc postgraduate students supervision
M.Sc Students
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Muram Al-Ghamdi
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Azza Al-Omari
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Shaima Houladar
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Abdullah BaKuraish
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Meshari Alharbi
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Arwa Alkhuzaimy
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Maram Hamed
Graduated Students
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Hadeel Baioumi
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Ashwag Almutairy
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Kholud Abdulmohsen
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Mariam Hamed
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Ferial Alharthi
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Arwa Alkhozaei
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Mamdouh Feda
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Omar Aloufi
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Tahgreed Baasha
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Noura Sattam
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Amnai Alghamdi
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Afaf Altalhei
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Dalal Alsaadi
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Shareifah Thubian
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Ashwag Almutaiery
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Abrar Mohammad
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Nuha Alamoudi
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Abeer Alshamrani
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Salwa Alhashemi
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Rawan Alghamdi
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Mahejeda Aljedani
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Raghda Badawood
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Aziza Badawood
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Last Update
6/3/2024 12:10:26 PM
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