kfmrc@kau.edu.sa

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Research

Publications

King Fahd Medical Research Center has more than 3.5 K of publications since 1981
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2018 Publications

1 A Clinical Update and Global Economic Burden of Rheumatoid Arthritis



2 Taxonogenomic description of four new Clostridium species isolated from human gut: ‘Clostridium amazonitimonense’, ‘Clostridium merdae’, ‘Clostridium massilidielmoense’ and ‘Clostridium nigeriense’ M. T. Alou1, S. Ndongo1, L. Frégère1, N. Labas1, C. Andrieu1, M. Richez1, C. Couderc1, J.-P. Baudoin1, J. Abrahão2, S. Brah3, A. Diallo1,4, C. Sokhna1,4, N. Cassir1, B. La Scola1, F. Cadoret1 and D. Raoult1,5



3 An Insight on the Pathogenesis and Treatment of Systemic Lupus Erythematosus Murtaza Ali1, Chelapram K. Firoz2, Nasimudeen R. Jabir2, Mohd Rehan2, Mohd S. Khan3 and Shams Tabrez2,*



4 An overview on the current status of cancer nanomedicines Nasimudeen R. Jabir, Khalid Anwar, Chelapram K. Firoz, Mohammad Oves, Mohammad Amjad Kamal & Shams Tabrez



5 Andrographolide, a diterpene lactone from Andrographis paniculata and its therapeutic promises in cancer Muhammad Torequl Islam a, b, c, 1, Eunüs S. Ali d, e, 1, 2, Shaikh Jamal Uddin f, Md. Amirul Islam f, Subrata Shaw g, Ishaq N. Khan h, Seyed Soheil Saeedi Saravi i, j, Saheem Ahmad k, Shahnawaz Rehman k, Vijai Kumar Gupta l, Mihnea-Alexandru Gaman m, n, Amelia Maria Gaman o, p, Santosh Yele q, Asish Kumar Das f, Jo~ao Marcelo de Castro e Sousa aa, Sandra Maria Mendes de Moura Dantas ab, Hercília Maria Lins Rolim r, Ana Amelia de Carvalho Melo-Cavalcante aa, Mohammad S. Mubarak s, Nagendra Sastry Yarla t, Jamil A. Shilpi f , Siddhartha Kumar Mishra u, Atanas G. Atanasov v, w, **, 3, Mohammad Amjad Kamal



6 Antitumor activity of pyrrolizines and their Cu(II) complexes: Design, synthesis and cytotoxic screening with potential apoptosis-inducing activity Ahmed M. Gouda a, b, Hoda A. El-Ghamry c, d, Tahani M. Bawazeer d, e, Thoraya A. Farghaly f, *, Ashraf N. Abdalla g, h, Akhmed Aslam i



7 Assessment of chemotherapy on various biochemical markers in breast cancer patients Márcia F. C. J. Paz1 | Antonio L. Gomes Júnior2 | Muhammad T. Islam3 | Shams Tabrez4 | Nasimudeen R. Jabir4 | Mohammad Z. Alam4 | Kátia C. Machado3 | Marcus V. O. B. de Alencar3 | Keylla C. Machado3 | Eunus S. Ali5 | Siddhartha K. Mishra6 | Leonardo F. Gomes3 | André Luiz Pinho Sobral7 | João M. C. e Sousa3 | Geane F. de Souza3 | Ana Amélia C. Melo-Cavalcante3 | Juliana da Silva1



8 Association Of Telomerase Activity With The Prognosis Of Diabetes Mellitus In Saudi Population Taha A. Kumosani1,2, Archana P. Iyer1,2,*, Ayat B. Al-Ghafari1,2 and Mazin A. Zamzami1



9 Careful use of 16S rRNA gene sequence similarity values for the identification of Mycobacterium species Mamadou Beye, Nidal Fahsi, Didier Raoult, Pierre-Edouard Fournier



10 Common Fibrillar Spines of Amyloid-β and human Islet Amyloid Polypeptide Revealed by Micro Electron Diffraction and Inhibitors Developed Using Structure-Based Design Pascal Krotee1*, Sarah L. Griner1*, Michael R. Sawaya1, Duilio Cascio1, Jose A. Rodriguez1, Dan Shi2, Stephan Philipp3, Kevin Murray1, Lorena Saelices1, Ji Lee1, Paul Seidler1, Charles G. Glabe3,4, Lin Jiang5, Tamir Gonen2, David S. Eisenberg1



11 Consequence of HIV and HCV co-infection on host immune response, persistence and current treatment options Sayed Sartaj Sohrab1 • Mohd Suhail3 • Ashraf Ali3 • Ishtiaq Qadri3 • Steve Harakeh1 • Esam I. Azhar1,2



12 Corynebacterium fournierii sp. nov., isolated from the female genital tract of a patient with bacterial vaginosis Khoudia Diop . Thi Tien Nguyen . Je´re´my Delerce . Nicholas Armstrong . Didier Raoult . Florence Bretelle . Florence Fenollar



13 Current therapies in alleviating liver disorders and cancers with a special focus on the potential of vitamin D Shahida Khan1*, Ashraf Ali1, Sarah Khan2, Ahmed Bakillah3, Ghazi Damanhouri1, Aziz Khan1, Ahmed Makki1, Ibtehal AlAnsari1 and Naheed Banu4



14 ِDengue infection in patients with febrile illness and its relationship to climate factors: A case study in the city of Jeddah, Saudi Arabia, for the period 2010–2014 Anwar M. Hashema,b,⁎, Turki Abujamela,c, Rowa Alhabbaba,c, Mansour Almazrouid,e, Esam I. Azhara



15 Diversity and antagonistic potential of bacteria isolated from marine grass Halodule uninervis Fehmida Bibi1 · Muhammad Imran Naseer3 · Ahmed Mohamad Hassan1 · Muhammad Yasir1 · Ahmed Abdullah Khalaf Al‑Ghamdi2 · Esam Ibrahim Azhar1,2



16 ِDraft Genome Sequence of Megamonas funiformis Strain Marseille-P3344, Isolated from a Human Fecal Microbiota Mossaab Maaloum,a,b Awa Diop,a Sokhna Ndongo,a Thi-Tien Nguyen,a Frederic Cadoret,a Didier Raoult,a,c Pierre-Edouard Fournier



17 Effect of atorvastatin on the gut microbiota of high fat diet-induced hypercholesterolemic rats Tariq Jamal Khan1, Youssri M. Ahmed1, Mazin A. Zamzami1, Saleh A. Mohamed1, Imran Khan 2, Othman A. S. Baothman1, Mohamed G. Mehanna1 & Muhammad Yasir3



18 “Enterococcus timonensis” sp. nov., “Actinomyces marseillensis” sp. nov., “Leptotrichia massiliensis” sp. nov., “Actinomyces pacaensis” sp. nov., “Actinomyces oralis” sp. nov., “Actinomyces culturomici” sp. nov., and “Gemella massiliensis” sp. nov., new bacterial species isolated from the human respiratory microbiome Maxime Descartes Mbogning Fonkou, Melhem Bilen, Frederic Cadoret, Pierre- Edouard Fournier, Gregory Dubourg, Didier Raoult



19 Enzyme targeting strategies for prevention and treatment of cancer: Implications for cancer therapy Mohammad Hassan Baiga, Mohd Adilb, Rosina Khanc, Surendar Dhadid, Khurshid Ahmada, Gulam Rabbania, Tufail Bashira, Mohammad Azhar Imrane, Fohad Mabood Husainf, Eun Ju Leea, Mohammad Amjad Kamalg,h, Inho Choia



20 Evidence and prospective of plant derived flavonoids as antiplatelet agents: Strong candidates to be drugs of future Harron Khan, Mohammad Jawad, Mohammad Ajmal Kamal, Alessandra Baldi, Jianbo Xiao, Seyed Mohammad Nabavi, Maria Daglia



21 Exploration of various proteins for the treatment of alzheimers disease



22 Exploring the interaction between Mycobacterium tuberculosis enolase and human plasminogen using computational methods and experimental techniques Amit Rahi1 | Alisha Dhiman1 | Damini Singh1 | Andrew M. Lynn3 | Mohd Rehan2 | Rakesh Bhatnagar1



23 Expression Profiling of Cytokine, Cholinergic Markers, and Amyloid- Deposition in the APPSWE/PS1dE9 Mouse Model of Alzheimer’s Disease Pathology Marcella Realea,1,∗, Chiara D’Angeloa, Erica Costantinia, Marta Di Nicolaa, Nagnedra Sastry Yarlac,1, Mohammad Amjad Kamald,e,f,∗, Nieves Salvadorb,1 and George Perryg



24 First complete genome sequence of circulating dengue virus serotype 3 in Jeddah, Saudi Arabia A. M. Hashem1,2, S. S. Sohrab1, S. A. El-Kafrawy1, S. A. El-Ela1, A. M. M. Abd-Alla5,6, S. A. Farraj1, N. A. Othman1, A. M. Hassan1, M. M. El-Daly1, R. N. Charrel1,7, T. A. Madani3 and E. I. Azhar1,4



25 Genetic characterization and diversity of circulating infuenza A/ H1N1pdm09 viruses isolated in Jeddah, Saudi Arabia between 2014 and 2015 Anwar M. Hashem1,2  · Esam I. Azhar1,3 · Sarah Shalhoub4  · Turki S. Abujamel1,3 · Norah A. Othman1  · Abdulwahab B. Al Zahrani5  · Hanan M. Abdullah6  · Maha M. Al‑Alawi1,2,7 · Anees A. Sindi8



26 Genetic risk factors in thrombotic primary antiphospholipid syndrome: A systematic review with bioinformatic analyses Md. Asiful Islam a, ⁎, Shahad Saif Khandker b,1 , Fahmida Alam a,1 , Mohammad Amjad Kamal c,d,e , Siew Hua Gan a,,



27 Genome sequence and description of Haloferax massiliense sp. nov., a new halophilic archaeon isolated from the human gut Saber Khelaifa1  · Aurelia Caputo1  · Claudia Andrieu1  · Frederique Cadoret1  · Nicholas Armstrong1  · Caroline Michelle1  · Jean‑Christophe Lagier1  · Felix Djossou2  · Pierre‑Edouard Fournier1  · Didier Raoult1,3



28 Gingerenone A Attenuates Monocyte-Endothelial Adhesion via Suppression of I Kappa B Kinase Phosphorylation Hee Joo Kim,1 Joe Eun Son,1,2 Jae Hwan Kim,1 Charles C. Lee,3 Hee Yang,1,2 Soonham Sami Yaghmoor,4 Youssri Ahmed,5 Jehad Mustafa Yousef,6 Khalid Omer Abualnaja,7 Abdulrahman Labeed Al-Malki,8 Taha Abdullah Kumosani,9 Jong Hun Kim,10 Jung Han Yoon Park,10 Chang Yong Lee,3,11* Jong-Eun Kim , 12** and Ki Won Lee1,



29 HCV genetics and genotypes dictate future antiviral strategies Louis Papageorgiou1,2, Chrisanthy Vlachakis3, Konstantina Dragoumani3, Sofia Raftopoulou4, Dimitrios Brouzas5, Nicolas C Nicolaides6,7, George P Chrousos6,7,8, Evangelia Charmandari6,7, Vasileios Megalooikonomou9, and Dimitrios Vlachakis



30 Identifcation of a monopartite begomovirus associated with yellow vein mosaic of Mentha longifolia in Saudi Arabia Sayed Sartaj Sohrab1  · Ihsanullah Daur2



31 Identification of novel inhibitors against UDP-galactopyranose mutase to combat leishmaniasis Mohammad Kashif1,2 | Shams Tabrez1 | Atahar Husein1 | Mohd Arish1 | Ponnusamy Kalaiarasan3 | Partha P. Manna2 | Naidu Subbarao3 | Yusuf Akhter4 | Abdur Rub



32 In silico identification of genes involved in chronic metabolic acidosis Ishfaq A. Sheikha,⁎ , Adeel Malikb , Sameera F.M. AlBasric , Mohd A. Bega



33 Inactivation of Middle East respiratory syndrome-coronavirus in human plasma using amotosalen and ultraviolet A light Salwa I. Hindawi,1,2 Anwar M. Hashem,3,4 Ghazi A. Damanhouri,2 Sherif A. El-Kafrawy,3,5 Ahmed M. Tolah,3 Ahmed M. Hassan,3 and Esam I. Azhar



34 Inhibiting Effect of Zinc Oxide Nanoparticles on Advanced Glycation Products and Oxidative Modifications: a Potential Tool to Counteract Oxidative Stress in Neurodegenerative Diseases Jalaluddin M. Ashraf1 & Mohammad Azam Ansari2 & Sana Fatma3 & Saleh M. S. Abdullah1 & Johar Iqbal4 & Aymen Madkhali1 & Al Hassan Hamali1 & Saheem Ahmad5 & Ahmed Jerah1 & Valentina Echeverria6 & George E. Barreto7 & Ghulam Md Ashraf8



35 Insights into the molecular mechanisms of stress and inflammation in ageing and frailty of the elderly Dimitrios Vlachakis1,2,3, Evangelia I Zacharaki1, Eirini Tsiamaki4, Maria Koulouri2, Sofia Raftopoulou2,5, Louis Papageorgiou2,6, George P Chrousos7,8,9, John Ellul4, and Vasileios Megalooikonomou1



36 Inventory, loading and discharge of synthetic phenolic antioxidants and their metabolites in wastewater treatment plants Wei Wang a , Kurunthachalam Kannan



37 Method for the Determination of Iodide in Dried Blood Spots from Newborns by High Performance Liquid Chromatography Tandem Mass Spectrometry Un-Jung Kim† and Kurunthachalam Kannan



38 Microbial culturomics to isolate halophilic bacteria from table salt: Genome sequence and description of the moderately halophilic bacterium Bacillus salis sp. nov. El hadji Seck, Awa Diop, Nicholas Armstrong, Jérémy Delerce, Pierre-Edouard Fournier, Didier Raoult, Saber Khelaifia



39 Microbial Flora Associated with the Halophyte–Salsola imbricate and Its Biotechnical Potential Fehmida Bibi 1 *, Gary A. Strobel 2 , Muhammad I. Naseer 3 , Muhammad Yasir 1 , Ahmed A. Khalaf Al-Ghamdi 4 and Esam I. Azhar 1,4



40 Plant-derived mPGES-1 inhibitors or suppressors: A new emerging trend in the search for small molecules to combat inflammation Haroon Khan, Kannan R.R. Rengasamy, Aini Perviaz, Seyed M. Nabavi, Atanas G. Atanasov, Mohammad A. Kamal



41 Prevalence of lifestyle practices that might affect bone health in relation to vitamin D status among female Saudi adolescents Rajaa Al-Raddadi M.D. a,*, Suhad Bahijri Ph.D. b , Anwar Borai Ph.D. c , Zeyad AlRaddadi Ph.D.



42 Propolis and Its Potential to Treat Gastrointestinal Disorders Luisa Mota da Silva , 1 Priscila de Souza,1 Soad K. Al Jaouni,2,3 Steve Harakeh , 3,4 Shahram Golbabapour , 5 and Sérgio Faloni de Andrade



43 Protein-Protein Interactions as Potential Targets of Drug Designing Zeeshan Zahoor Banday,Ghulam Md Ashraf



44 Resin-based dental sealants as a source of human exposure to bisphenol analogues, bisphenol A diglycidyl ether, and its derivatives Jingchuan Xuea,1 , Pranav Kannana,1 , Taha A. Kumosanib , Abdulrahman L. Al-Malkic , Kurunthachalam Kannana



45 Reverse micelle Extraction of Antibiotics using an Eco-friendly Sophorolipids Biosurfactant Sing Chuong Chuo1, Norfahana Abd-Talib1, Siti Hamidah Mohd-Setapar1,2,3, Hashim Hassan1, Hasmida Mohd Nasir2, Akil Ahmad2,4, David Lokhat4 & Ghulam Md. Ashraf



46 Sediminibacillus massiliensis sp. nov., a moderately halophilic, Gram-positive bacterium isolated from a stool sample of a young Senegalese man Bruno Senghor . Hubert Basse`ne . Saber Khelaifia . Catherine Robert . Pierre-Edouard Fournier . Raymond Ruimy . Cheikh Sokhna . Didier Raoult . Jean-Christophe Lagier



47 Spatial distribution of bisphenol S in surface water and human serum from Yangtze River watershed, China: Implications for exposure through drinking water Yanjian Wan, Wei Xia, Shunyi Yang, Xinyun Pan, Zhenyu He, Kurunthachalam Kannan



48 Synthetic Strigolactone Analogues Reveal Anti-Cancer Activities on Hepatocellular Carcinoma Cells Mohammed Nihal Hasan, Hani Choudhry, Syed Shoeb Razvi, Said Salama Moselhy, Taha Abduallah Kumosani, Mazin A. Zamzami, Ziad Omran, Majed A. Halwani, Salim Al-Babili, Khalid Omer Abualnaja, Abdulrahman Labeed Al-Malki, Mahmoud Alhosin, Tadao Asami



49 Targeting microRNA/UHRF1 pathways as a novel strategy for cancer therapy (Review) HANI CHOUDHRY1-4 , MAZIN A. ZAMZAMI1-3 , ZIAD OMRAN5 , WEI WU6 , MARC MOUSLI7 , CHRISTIAN BRONNER8 and MAHMOUD ALHOSIN



50 Taxonogenomic description of four new Clostridium species isolated from human gut: ‘Clostridium amazonitimonense’, ‘Clostridium merdae’, ‘Clostridium massilidielmoense’ and ‘Clostridium nigeriense’ M. T. Alou1 , S. Ndongo1 , L. Frégère1 , N. Labas1 , C. Andrieu1 , M. Richez1 , C. Couderc1 , J.-P. Baudoin1 , J. Abrahão2 , S. Brah3 , A. Diallo1,4 , C. Sokhna1,4 , N. Cassir1 , B. La Scola1 , F. Cadoret1 and D. Raoult1,5



51 The Correlation between Depression and Folate Deficiency Ahmad Sami A Himayda 1 , Ahmed Fouzi Abdulkader 2 , Nora Ayman Brazanji 3 , Sultan Ali M Alshehri 4 , Suha Salah Ibrahim Alqayn 5 , Hasan Sharif H Bukhari 1 , Fadia A AbuZaid (1,2 ) 6 , Muhannad Azim Ghareeb ALanazi 7 , Ahmed Mohammed Abdulsalam Alhayani 8 , Shima Ali Albather 9 , Ameen Nafi Roeie Aljabri 10 , Ahmad Abdulkarim Alanizi 11



52 The demosponge Pseudoceratina purpurea as a new source of fibrous chitin Sonia Żółtowska- Aksamitowska, Mikhail Tsurkan, Swee–Cheng Lim, Heike Meissner, Konstantin Tabachnick, Lamiaa A. Shaala, Diaa T.A. Youssef, Viatcheslav N. Ivanenko, Iaroslav Petrenko, Marcin Wysokowski, Nicole Bechmann, Yvonne Joseph, Teofil Jesionowski, Hermann Ehrlich



53 The emergence of carbapenem-resistant Klebsiella pneumoniae isolates producing OXA-48 and NDM in the Southern (Asir) province, Saudi Arabia Ibrahim A. Al-Zahrani, MSc, PhD, Bander A. Alasiri, BSc, MSc.



54 The impact of air pollutants, UV exposure and geographic location on vitamin D deficiency Edris Hoseinzadeh, Parisa Taha, Chiang Wei, Hatam Godini, Ghulam Md Ashraf, Mahmoud Taghavi, Mohammad Miri d



55 Ultrastructural Features of Alkhumra Hemorrhagic Fever Virus Infection of Cells Under In Vivo and In Vitro Conditions Tariq A. Madani,1,2 El-Tayb M.E. Abuelzein,2,3 Huda Abu-Araki,2,4 Soad S. Ali,5 Sawsan M. Jalalah,6 Ahmed M. Hassan,2,3 Hussein M.S. Al-Bar,2,7 and Esam I. Azhar2,3,



56 Urinary levels of triclosan and triclocarban in several Asian countries, Greece and the USA: Association with oxidative stress Archana P. Iyera,b,c,d , Jingchuan Xuee , Masato Hondae , Morgan Robinsone , Taha Abdullah Kumosania,b,d , Khalid Abulnajaa,f , Kurunthachalam Kannana,



57 Advances in Hypoxia-Inducible Factor Biology Hani Choudhry1 and Adrian L. Harris2,3, *



58 An ICET- A survey on hypoparathyroidism in patients with thalassaemia major and intermedia: a preliminary report Vincenzo De Sanctis1 , Ashraf T. Soliman2 , Duran Canatan3 , Heba Elsedfy 4, Mehran Karimi5 , Shahina Daar6 , Hala Rimawi7 , Soteroula Christou 8, Nicos Skordis9 , Ploutarchos Tzoulis10, Praveen Sobti11, Shruti Kakkar12, Yurdanur Kilinc13, Doaa Khater14, Saif A Alyaarubi 5, Valeriya Kaleva16, Su Han Lum17, Mohamed A Yassin18, Forough Saki19, Maha Obiedat20, Salvatore Anastasi 21, Maria Concetta Galati 22, Giuseppe Raiola23, Saveria Campisi24 , Nada Soliman25, Mohamed Elshinawy26, Soad Al Jaouni27, Salvatore Di Maio28,Yasser Wali29, Ihab Zaki Elhakim30, Christos Kattamis31



59 An Insight into the Therapeutic Potential of Major Coffee Components Muhammad Torequl Islam1,2, Shams Tabrez3,*, Nasimudeen R Jabir3 , Murtaza Ali4 , Mohammad Amjad Kamal3 , Lidiane da Silva Araújo5 , Jose Victor de Oliveira Santos5 , Ana Maria Oliveira Ferreira da Mata5 , Rai Pablo Sousa de Aguiar5 and Ana Amélia de Carvalho Melo Cavalcante5



60 An insight on the association of glycation with hepatocellular carcinoma Nasimudeen R. Jabira , Saheem Ahmadb , Shams Tabreza



61 Analysis of bacterial communities and characterization of antimicrobial strains from cave microbiota Muhammad Yasir



62 Analysis of SNPs of MC4R , GNB3 and FTO gene polymorphism in obese Saudi subjects. Said Salama Moselhy1,4,6,7*, Yasmeen A Alhetari1 , Archana Iyer1,4,5, Etimad A Huwait1 , Maryam A AL-Ghamdi1 , Shareefa AL-Ghamdi1 , Khadijah Saeed Balamash1 , Ashraf A Basuni2,8, Mohamed N Alama3 , Taha A Kumosani1,4,5, Soonham Sami Yaghmoor4,5



63 Anticancer Profiling for Coumarins and Related O-Naphthoquinones from Mansonia gagei against Solid Tumor Cells In Vitro Mohammed A. Baghdadi 1,2 ID , Fahad A. Al-Abbasi 1 , Ali M. El-Halawany 3,4, Ali H. Aseeri 5 and Ahmed M. Al-Abd 4,6,* ID



64 Antidepressant Potential of Peptides: New Insights as Future Therapeutic ,Haroon Khan1,*, Sumaira Khattak1 , Mohammad S. Mubarak2 , Saud S. Bawazeer3 Tareq Abu-Izneid3 and Mohammad A. Kamal4,



65 Antimicrobial and anticancer activities of silver nanoparticles synthesized from the root hair extract of Phoenix dactylifera Mohammad Ovesa,⁎ , Mohammad Aslama , Mohd Ahmar Raufb , Shariq Qayyumb , Huda A. Qaria,c , Mohd Shahnawaz Khand , Mohammad Zubair Alame , Shams Tabreze , Arivalagan Pugazhendhif , Iqbal M.I. Ismaila,g



66 Association of HCV mutated proteins and host SNPs in the development of hepatocellular carcinoma Mohd Suhaila , Sayed Sartaj Sohrabb , Abid Qureshic , Mohd Tariqued , Hany Abdel-Hafize , Khalid Al-Ghamdif , Ishtiaq Qadrif,⁎



67 Atorvastatin Treatment Modulates the Gut Microbiota of the Hypercholesterolemic Patients Tariq Jamal Khan,1 Youssri M. Ahmed,1 Mazin A. Zamzami,1 Aisha M. Siddiqui,2 Imran Khan,3 Othman A.S. Baothman,1 Mohamed G. Mehanna,1 Abudukadeer kuerban,1 Mohammed Kaleemuddin,1 and Muhammad Yasir4



68 Attenuation of TNF-α Induced Liver Injury by Cinnamon Extract in Rats Khadijah S. Balamash1 , Said S. Moselhy1,2,3,4* , Jehan A. Khan5 , Etimad H. Huwait1 , Nawal Helmi1 , Khalid O. Abulnaja1,2,3 , Widad M. Al-Bishri1 , Abdulrahman L. AL-Malki1,2,3, Taha A. Kumosani1,2,6 and Soonham S. Yaghmoor2,3



69 Bacillus kwashiorkori sp. nov., a new bacterial species isolated from a malnourished child using culturomics El hadji Seck1 | Mamadou Beye1 | Sory Ibrahima Traore1 | Saber Khelaifia1 | Caroline Michelle1 | Carine Couderc1 | Souleymane Brah2 | Pierre-Edouard Fournier1 | Didier Raoult1,3 | Fadi Bittar1



70 Blocking of cytokines signalling attenuates evoked and spontaneous neuropathic pain behaviours in the paclitaxel rat model of chemotherapy-induced neuropathy S. Al-Mazidi1,2, M. Alotaibi1 , T. Nedjadi3 , A. Chaudhary4 , M. Alzoghaibi1 , L. Djouhri1



71 Boosting Alfalfa (Medicago sativa L.) Production With Rhizobacteria From Various Plants in Saudi Arabia Ihsanullah Daur1, Maged M. Saad2,3, Abdul Aziz Eida3, Shakeel Ahmad4, Zahid Hussain Shah1, Muhammad Z. Ihsan5, Yasir Muhammad6, Sayed S. Sohrab6 and Heribert Hirt3*



72 Changes in erythrocyte ATPase activity under different pathological conditions. Ali A Kherd1 , Nawal Helmi1,2, Khadijah Saeed Balamash1 , Taha A Kumosani1,2,3, Shareefa A AL-Ghamdi1 , Qari M4 , Etimad A Huwait1 , Soonham S Yaghmoor2,3, Alaama Nabil5 , Maryam A AL-Ghamdi1 , Said S Moselhy1,2,



73 Characterization of a New Ezakiella Isolated from the Human Vagina: Genome Sequence and Description of Ezakiella massiliensis sp. nov. Khoudia Diop1 · Claudia Andrieu1 · Caroline Michelle1 · Nicholas Armstrong1 · Fadi Bittar1 · Florence Bretelle1,2 · Pierre‑Edouard Fournier1 · Didier Raoult1,3 · Florence Fenollar



74 Characterization of a novel Gram-stain-positive anaerobic coccus isolated from the female genital tract: Genome sequence and description of Murdochiella vaginalis sp. nov. Khoudia Diop1 | Awa Diop1 | Saber Khelaifia1 | Catherine Robert1 | Fabrizio Di Pinto1 | Jérémy Delerce1 | Didier Raoult1,2 | Pierre-Edouard Fournier1 | Florence Bretelle1,3 | Florence Fenollar



75 Chemosensitizing activity of histone deacetylases inhibitory cyclic hydroxamic acids for combination chemotherapy of lymphatic leukemia



76 Cholinesterase targeting by polyphenols: A therapeutic approach for the treatment of Alzheimer’s disease Nasimudeen R. Jabir1 | Fayaz Rahman Khan2 | Shams Tabrez



77 Conditioned Medium of Human Adipose Mesenchymal Stem Cells Increases Wound Closure and Protects Human Astrocytes Following Scratch Assay In Vitro Eliana Baez-Jurado1 & Oscar Hidalgo-Lanussa1 & Gina Guio-Vega1 & Ghulam Md Ashraf2 & Valentina Echeverria3,4 & Gjumrakch Aliev5,6,7 & George E. Barreto



78 Correction to: Current therapies in alleviating liver disorders and cancers with a special focus on the potential of vitamin D Shahida Khan1*, Ashraf Ali1 , Sarah Khan2 , Ahmed Bakillah3 , Ghazi Damanhouri1 , Aziz Khan1 , Ahmad Makki1 , Ibtehal AlAnsari1 and Naheed Banu



79 Current and Future Methods for mRNA Analysis: A Drive Toward Single Molecule Sequencing Anthony Bayega, Somayyeh Fahiminiya, Spyros Oikonomopoulos, and Jiannis Ragoussis



80 Current Vision of Systemic Autoimmune Diseases - From Diagnosis to Management



81 Design and Delivery of Therapeutic siRNAs: Application to MERS-Coronavirus , Esam Azhar , Zinat Mirza



82 Detrimental association between diabetes and tuberculosis: An unresolved double trouble Ali Nasir Siddiquia , Salman Hussaina , Nahida Siddiquib , Khalid Umer Khayyamc , Shams Tabrezd , Manju Sharmae, *



83 Development of Fluorescent Reverse Transcription Loop-mediated Isothermal Amplification (RT-LAMP) using Quenching Probes for the Detection of the Middle East Respiratory Syndrome Coronavirus Authors: Kazuya Shirato, Shohei Semba, Sherif A. El-Kafrawy, Ahmed M. Hassan, Ahmed M. Tolah, Ikuyo Takayama, Tsutomu Kageyama, Tsugunori Notomi, Wataru Kamitani, Shutoku Matsuyama, Esam Ibraheem Azhar



84 Diversity of Dengue Virus-3 Genotype III in Jeddah, Saudi Arabia Authors: Anwar M. Hashem, Sayed S. Sohrab, Sherif A. El-Kafrawy, Adly M.M. Abd-Alla, Saeid Abo El-Ela, Turki S. Abujamel, Ahmed M. Hassan, Suha A. Farraj *



85 Draft Genome Sequence of Ezakiella peruensis Strain M6.X2, a Human Gut Gram-Positive Anaerobic Coccus Awa Diop,a Khoudia Diop,a Enora Tomei,a Didier Raoult,a,b Florence Fenollar,a Pierre-Edouard Fourniera



86 Draft genome sequence of Fermentimonas caenicola strain SIT8, isolated from the human gut Mamadou Beye1 , Sofiane Bakour1 , Sory Ibrahima Traore1 , Jaishriram Rathored1 , Noémie Labas1 , Didier Raoult1,2 and Pierre-Edouard Fournier1



87 Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer’s disease Justyna Sosna1 , Stephan Philipp1 , Ricardo Albay III1 , Jorge Mauricio Reyes-Ruiz1 , David Baglietto-Vargas3 , Frank M. LaFerla3 and Charles G. Glabe



88 Encapsulation of 5-Flurouracil into PLGA Nanofibers and Enhanced Anticancer Effect in Combination with Ajwa-Dates-Extract (Phoenix dactylifera L.)



89 Erratum: Biogenic synthesis of Zinc oxide nanostructures from Nigella sativa seed: Prospective role as food packaging material inhibiting broad-spectrum quorum sensing and biofilm NasserA.Al-Shabib, Fohad Mabood Husain, FaheemAhmed, RaisAhmad Khan, IqbalAhmad, EdreeseAlsharaeh, Mohd Shahnawaz Khan, Afzal Hussain, MdTabish Rehman, MohammadYusuf, Iftekhar Hassan, Javed Masood Khan, Ghulam MdAshraf, AliAlsalme, Mohamed F.Al-Ajmi, VadimV.Tarasov & GjumrakchAliev



90 Exosomes: A paradigm in drug development against cancer and infectious diseases Mohammad Oves1,*, Huda A Qari1,2, Nadeen M Felemban1 , Aftab Aslam Parwaz Khan3 , Mohd Rehan4 , Shams Tabrez4 , Faheem Ahmed5 , Ashanul Haque6 , Mohammad S Khan7 , Javed M Khan8 , Fohad M Husain8 , Afzal Hussain 9 , Mohiuddin Khan Warsi 10, Iqbal IM Ismail



91 First Report on Chitin in a Non-Verongiid Marine Demosponge: The Mycale euplectellioides Case Sonia Żółtowska-Aksamitowska 1,2 , Lamiaa A. Shaala 3,4 , Diaa T. A. Youssef 5,6 , Sameh S. Elhady 5 , Mikhail V. Tsurkan 7 , Iaroslav Petrenko 2 , Marcin Wysokowski 1 , Konstantin Tabachnick 8 , Heike Meissner 9 , Viatcheslav N. Ivanenko 10, Nicole Bechmann 11, Yvonne Joseph 12 , Teofil Jesionowski 1 , and Hermann Ehrlich 2,*



92 Flavonoids as acetylcholinesterase inhibitors: Current therapeutic standing and future prospects Haroon Khana,⁎ , Maryaa , Surriya Aminb , Mohammad Amjad Kamalc,d,e , Seema Patelf,



93 Frontier View on Nanotechnological Strategies for Neuro-therapy



94 Genetic diversity and phylogenetic analysis of HPV 16 & 18 variants isolated from cervical specimens of women in Saudi Arabia Khalid Sait a,⇑ , Rola Turki a , Adel Mohammed Abuzenadah b , Osama H. Jiffiri a , Abdulbaset Bohmaidah c , Sayed Sartaj Sohrab b



95 Genome sequence and description of Gracilibacillus timonensis sp. nov. strain Marseille-P2481T , a moderate halophilic bacterium isolated from the human gut microflora Awa Diop1 | El hadji Seck1 | Gregory Dubourg1 | Nicholas Armstrong1 | Caroline Blanc-Tailleur1 | Didier Raoult1,2 | Pierre-Edouard Fournier



96 Gingerenone A Attenuates Monocyte-Endothelial Adhesion via Suppression of I Kappa B Kinase Phosphorylation Hee Joo Kim,1 Joe Eun Son,1,2 Jae Hwan Kim,1 Charles C. Lee,3 Hee Yang,1,2 Soonham Sami Yaghmoor,4 Youssri Ahmed,5 Jehad Mustafa Yousef,6 Khalid Omer Abualnaja,7 Abdulrahman Labeed Al-Malki,8 Taha Abdullah Kumosani,9 Jong Hun Kim,10 Jung Han Yoon Park,10 Chang Yong Lee,3,11* Jong-Eun Kim , 12** and Ki Won Lee1,2,



97 Global spread of antibiotic-resistant bacteria and mass-gathering religious events



98 Halophytes-associated endophytic and rhizospheric bacteria: diversity, antagonism and metabolite production Fehmida Bibi, Gary Allan Strobel, Muhammad Imran Naseer, Muhammad Yasir, Ahmed Abdullah Khalaf Al-Ghamdi & Esam Ibrahim Azhar



99 Herbal Medicines Useful to Treat Inflammatory and Ulcerative Gastrointestinal Disorders: Preclinical and Clinical Studies Sérgio Faloni de Andrade , 1 Luisa Mota da Silva , 1 Shahram Golbabapour , 2 and Steve Harakeh 3



100 Implication of nano-antioxidant therapy for treatment of hepatocellular carcinoma using PLGA nanoparticles of rutin



101 In silico Structure-based Identification of Novel Acetylcholinesterase Inhibitors Against Alzheimer’s Disease ,Kanzal Iman1 , Muhammad Usman Mirza2,3*, Nauman Mazhar4 , Michiel Vanmeert3 , Imran Irshad5 and Mohammad A. Kamal6,7,



102 In situ characterization of stem cells-like biomarkers in meningiomas Hanin Alamir1†, Mona Alomari2†, Abdulla Ahmed A. Salwati2 , Mohamad Saka2 , Mohammed Bangash3 , Saleh Baeesa3 , Fahad Alghamdi4 , Angel Carracedo5,6, Hans‑Juergen Schulten6 , Adeel Chaudhary1,6,7, Adel Abuzenadah1,2,7 and Deema Hussein2*



103 Melamine and its derivatives in dog and cat urine: An exposure assessment study* Rajendiran Karthikraj a , Rasya Bollapragada a , Kurunthachalam Kannan a,



104 Microbial Culturomics Broadens Human Vaginal Flora Diversity: Genome Sequence and Description of Prevotella lascolaii sp. nov. Isolated from a Patient with Bacterial Vaginosis Khoudia Diop,1 Awa Diop,1 Anthony Levasseur,1 Oleg Mediannikov,1 Catherine Robert,1 Nicholas Armstrong,1 Carine Couderc,1 Florence Bretelle,2 Didier Raoult,1,3 Pierre-Edouard Fournier,1 and Florence Fenollar1



105 Middle East respiratory syndrome coronavirus: risk factors and determinants of primary, household, and nosocomial transmission David S Hui, Esam I Azhar, Yae-Jean Kim, Ziad A Memish, Myoung-don Oh, Alimuddin Zumla



106 Molecular docking and in vitro studies of soap nut trypsin inhibitor (SNTI) against phospholipase A2 isoforms in therapeutic intervention of inflammatory diseases Gandreddi V.D. Sirisha, K. Vijaya Rachel, Kunal Zaveri, Nagendra Sastry Yarla, P. Kiranmayi, Magdah Ganash, Huda Mohammad Alkreathy, Nisreen Rajeh, Ghulam M.D. Ashraf



107 Molecular evidence for the occurrence of TYLCV on Mentha longifolia in Jeddah, Saudi Arabia Sayed Sartaj Sohrab1 • Ihsanullah Daur2



108 New paradigm in ankyrin repeats: Beyond protein-protein interaction module Zeyaul Islama,∗, Raghavendra Sashi Krishna Nagampalli a, Munazza Tamkeen Fatima b, Ghulam Md Ashraf c,∗



109 Nigella sativa oil protects against tartrazine toxicity in male rats Madeha N. Al-Seenia , Haddad A. El Rabeyb,c,⁎ , Amani Mohammed Al-Hameda , Mazin A. Zamazam



110 Parabens and Their Metabolites in Pet Food and Urine from New York State, United States



111 Parabens in human urine from several Asian countries, Greece, and the United States Masato Honda, Robinson Morgan, Kurunthachalam Kannan



112 Peptide based therapeutics and their use for the treatment of neurodegenerative and other diseases Mohammad Hassan Baiga,⁎ , Khurshid Ahmada , Mohd Saeedb , Ahmed M Alharbib , George E. Barretoc,d , Ghulam Md Ashrafe , Inho Choia,



113 Peptoniphilus lacydonensis sp. nov., a new human-associated species isolated from a patient with chronic refractory sinusitis M. Beye1 , S. Bakour1 , E. Le Dault1 , J. Rathored1 , C. Michelle2 , F. Cadoret2 , D. Raoult2,3 and P.-E. Fournier1



114 Prevalence and Risk Factors of Fatty Liver among Adults Abdullah Obaid Binobaid 1 , Mohannad Abdulrazzaq Alalwan 2 , Abdullah Hussaen A Almalki 3 , Saad Khalid N Almaghrabi 3 , Mohanned Khder H Sharif 4 , Abdulrahman Adel N Alomair 5 , Murtadha Dhiya H. Alsultan 6 , Obaid abdullah O alhamid 7 , Rana R. AL-Rasheed 8 , Amro Mohammed Alamro 9 , Mohammed Ibrahim A Alsaleh 10 , Zahra Naji AlAithan 2



115 Prevalence of hepatitis B and hepatitis C Virus infections among male to female (MFT) transgenders in Rawalpindi (Pakistan) Hashaam Akhtar1,5*, Yasmeen Badshah1 , Samar Akhtar2,5, Faheem Hasan3 , Muhammad Faisal4 , Najam us Sahar Sadaf Zaidi1 , Ishtiaq Qadri6



116 Prospects of IL-2 in Cancer Immunotherapy Hani Choudhry , 1 Nawal Helmi , 1 Wesam H. Abdulaal,1 Mustafa Zeyadi,1 Mazin A. Zamzami,1 Wei Wu,2 Maged Mostafa Mahmoud,3,4 Mohiuddin Khan Warsi,5 Mahmood Rasool,6 and Mohammad S. Jamal 3



117 Recent Updates on Biomarkers of Gastric Cancer



118 Retraction notice to Inhibition of proliferation and induction of apoptosis by 2-benzoyl-3-phenyl-6,7-dichloroquinoxaline 1,4-dioxide in adult T-cell leukemia cells Steve Harakeha , Mona Diab-Assefa , Marwan El-Sabbanb , Makhluf Haddadinc , Hala Gali-Muhtasiba



119 Sanguibacter massiliensis sp. nov., Actinomyces minihominis sp. nov., Clostridium minihomine sp. nov., Neobittarella massiliensis gen. nov., and Miniphocibacter massiliensis gen. nov., new bacterial species isolated by culturomics from human stool samples. Melhem Bilen, Maxime Descartes Mbogning Fonkou, Frédéric Cadoret, Gregory Dubourg, Ziad Daoud, Didier Raoult



120 Spatial distribution of bisphenol S in surface water and human serum from Yangtze River watershed, China: Implications for exposure through drinking water Yanjian Wan a, b, c, 1 , Wei Xia b, 1 , Shunyi Yang c , Xinyun Pan a , Zhenyu He a, **, Kurunthachalam Kannan d, e



121 Studies on immunological and degranulation properties of a galectin-1 purified from goat (Capra hircus) heart Ghulam Md Ashraf, Maged Mostafa Mahmoud, Shams Tabrez



122 Synthetic strigolactone analogues reveal anti-cancer activities on hepatocellular carcinoma cells Mohammed Nihal Hasan a , Hani Choudhry a,b,c,e,l , Syed Shoeb Razvi a,l , Said Salama Moselhy a,d,e,f , Taha Abduallah Kumosani a,d,j , Mazin A. Zamzami a,b,c , Ziad Omran g , Majed A. Halwani h , Salim Al-Babili i , Khalid Omer Abualnaja a,d,e , Abdulrahman Labeed Al-Malki a,d,e , Mahmoud Alhosin a,b,c,⇑,l , Tadao Asami a,k,⇑,



123 Taking forward the Stop TB Partnership and World Health Organization Joint Theme for World TB Day March 24th 2018 — “Wanted: Leaders for a TB-Free World. You can make history. End TB”



124 Targeting Arachidonic Acid PathwayAssociated NF-κB in Pancreatic Cancer Nagendra Sastry Yarla, Olga Sukocheva, Ilaria Peluso, Swathi Putta, Pallaval Veera Bramhachari, Rajesh Yadala, Dinesh K. Tiwari, Srinivas Jagarlamudi, Luciana Scotti, Marcus T. Scotti, Marcella Reale, Mohammad Amjad Kamal, Ashraf Ghulam, Bechan Sharma, Madhukiran Parvathaneni, Chinthalapally V. Rao, Mastan Mannarapu, and Anupam Bishayee



125 The cytochrome P450 isoenzyme and some new opportunities for the prediction of negative drug interaction in vivo Dmitrij A Sychev,1 Ghulam Md Ashraf,2 Andrey A Svistunov,3 Maksim L Maksimov,4 Vadim V Tarasov,3 Vladimir N Chubarev,3 Vitalij A Otdelenov,1 Natal’ja P Denisenko,1 George E Barreto,5,6 Gjumrakch Aliev7–9



126 The Role of microRNAs in Alzheimer’s Disease and Their Therapeutic Potentials Munvar Miya Shaik 1 , Ian A. Tamargo 2 , Murtala B. Abubakar 3 ID , Mohammad A. Kamal 4 ID , Nigel H. Greig 2 and Siew Hua Gan 5,* ID



127 The Use of Azoles Containing Natural Products in Cancer Prevention and Treatment: An Overview Nasimudeen R. Jabir a , Chelapram K. Firoz a , Ashish Bhushanb,c , Shams Tabrez a,* and Mohammad A. Kamal a,d,e



128 Transcript Profiling Using Long-Read Sequencing Technologies Anthony Bayega, Yu Chang Wang, Spyros Oikonomopoulos, Haig Djambazian, Somayyeh Fahiminiya, and Jiannis Ragoussis



129 Discovery of chitin in skeletons of nonverongiid Red Sea demosponges Hermann Ehrlich1 *, Lamiaa A. Shaala2,3, Diaa T. A. Youssef4,5, Sonia Żo´łtowskaAksamitowska6 , Mikhail Tsurkan7 , Roberta Galli8 , Heike Meissner9 , Marcin Wysokowski6 , Iaroslav Petrenko1 , Konstantin R. Tabachnick10, Viatcheslav N. Ivanenko11, Nicole Bechmann12, Yvonne Joseph13, Teofil Jesionowsk



130 Identification of Electrophysiological Changes in Alzheimer’s Disease: A Microarray Based Transcriptomics and Molecular Pathway Analysis Study, Zeenat Mirza



131 A Critical Appraisal of Different Food Safety and Quality Management Tools to Accomplish Food Safety Siva K. Korada⁎ , Nagendra S. Yarla† , Swathi Putta‡ , Avinash S. Hanumakonda⁎ , Dhananjaya B. Lakkappa§ , Anupam Bishayee¶, Luciana Scottiǁ , Marcus T. Scottiǁ , Gjumrakch Aliev#, Mohammad A. Kamal‡‡,§§, Da-Yong Lu, Mukerrem B.Y. Aycanǁǁ, Raffaella Reggi, Maura Palmery, Ghulam Ashraf‡‡, Thonas Alexiou§§, Ilaria Peluso



132 A novel antioxidant and antimicrobial compound produced by Bacillus firmicutes. Youssri M Ahmed1,2,3*, Ibtihaj J Jambi1



133 APutative Association of Interleukin-1β Promoter Polymorphisms and IL-1β Levels in Saudi Diabetic Patients Shams Tabrez,a,* Ghulam Md. Ashraf,a & Salwa Hindawib



134 A Putative Association of Interleukin-10 Promoter Polymorphisms with Cardiovascular Disease Shams Tabrez 1* Murtaza Ali2 Nasimudeen R. Jabir1 Chelapram K. Firoz1 Ghulam Md. Ashraf1 Salwa Hindawi3 Ghazi A. Damanhouri1 Mohammed Nabil Alama



135 A rapid method for the analysis of perfluorinated alkyl substances in serum by hybrid solid-phase extraction Masato Honda, A Morgan RobinsonA and Kurunthachalam Kannan



136 A Short and Efficient Total Synthesis of Ficuseptamines A and B Hani Mutlak A. Hassan



137 An insight towards anticancer potential of major coffee constituents Nasimudeen R. Jabir1 Muhammad Torequl Islam2,3* Shams Tabrez 1 * Shazi Shakil4,5,6 Syed Kashif Zaidi6 Fayaz Rahman Khan7 Lidiane da Silva Araújo8 Ag-Anne Pereira Melo de Meneses8 José Victor de Oliveira Santos8 Ana Amélia de Carvalho MeloCavalcante8



138 Anaerococcus jeddahensis sp. nov., a New Bacterial Species Isolated From Healthy Nomadic Bedouin Woman From Saudi Arabia Niokhor Dione1 · Sara Bellali1 · Muhammad Yasir2 · Esam I. Azhar2,3 · Fehmida Bibi2 · Mamadou Beye1 · Nicholas Armstrong1 · Frédéric Cadoret1 · Asif A. Jiman‑Fatani3 · Nayel Helmy4 · Jaishriram Rathored1 · Noémie Labas1 · Pierre‑Edouard Fournier1 · Didier Raoult1,2 · Jean‑Christophe Lagier1



139 Analysis of Hepatitis B virus (HBV) mutations in patients from Western Saudi Arabia with chronic disease Sherif Aly El-Kafrawy1 , Ghazi Abdulatif Jamjoom1 , Hisham Othman Akbar2 , Hind Ibrahim Baker Fallatah2 , Mai Mohamed El-Daly1 , Yousef Abdulfattah Qari3 , Abdullah Saeed Alghamdi4 , Mohamed Babatin5 , Mohammed Abdullah Alsaedi1 , Norah Abdulhamid Othman1 , Tagreed Lafi Al-Subhi1 , Mohamed AbdelHamid6,7, Esam Ibraheem Azhar1



140 Analysis of terephthalate metabolites in human urine by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) Shedrack R. Nayebarea,b,1 , Rajendiran Karthikraja,1 , Kurunthachalam Kannan



141 Antibody and Antigen Interaction chapter



142 APOE and Alzheimer’s Disease: Evidence Mounts that Targeting APOE4 may Combat Alzheimer’s Pathogenesis Md. Sahab Uddin1 & Md. Tanvir Kabir2 & Abdullah Al Mamun1 & Mohamed M. Abdel-Daim3,4 & George E. Barreto5,6 & Ghulam Md Ashraf



143 Assessment Of Possible Association Between Antioxidant Levels And Apoe Gene Polymorphism In Demented Saudi Population Ohoud A. Alomari1 , Taha A.Kumosani 1 , Archana P. Iyer1 , Etimada. Huwait1 , Mohammed S. Bamaga2 , Naglaa M. Salim3 , Charles G. Glabe



144 Association of Metronidazole with Cancer: A Potential Risk Factor or Inconsistent Deductions?



145 Association of serum asymmetric dimethyl-arginine and troponin I levels as a risk of myocardial infarction in thalassemia Nawal Helmi1 , Hani Choudhry1,2, Qari M3 , Taha A Kumosani1,2,4,5, Abdulrahman L AL-Malki1,2,6, Said Salama Moselhy1,4,6,7, Afnan T Kumosani




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9/16/2024 12:18:18 PM