kfmrc@kau.edu.sa

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Research

Publications

King Fahd Medical Research Center has more than 3.5 K of publications since 1981
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2017 Publications

1 Alam, M. Z., Alam, Q. & Jiman-fatani, A. A. A surveillance study on the prevalence and antimicrobial resistance pattern among different groups of bacteria isolated from Western province of Saudi Arabia . 28, (2017)

2 Boutajangout, A., Noorwali, A., Atta, H. & Wisniewski, T. Human Umbilical Cord Stem Cell Xenografts Improve Cognitive Decline and Reduce the Amyloid Burden in a Mouse Model of Alzheimer’s Disease. Curr. Alzheimer Res. 1–8 (2016). doi:10.2174/1567205013666161004

3 Diop, K., Raoult, D., Bretelle, F. & Fenollar, F. ‘Ezakiella massiliensis’ sp. nov., a new bacterial species isolated from human female genital tract. New Microbes New Infect. 15, 16–17 (2017)

4 Durand, G. A. et al. Blautia massiliensis sp. nov., isolated from a fresh human fecal sample and emended description of the genus Blautia. Anaerobe (2016). doi:10.1016/j.anaerobe.2016.12.001

5 Mourembou, G. et al. Discovery of a new species within Bacillus genus in a stool sample from Gabon: ‘Bacillus massiliogabonensis’ sp. nov. New Microbes New Infect. 15, 3–5 (2017)

6 Palipoch, S. & Thammarat, N. S. Palipoch Afr J Tradit Complement Altern Med . ( 2013 ) 10 ( 4 ): 88-93. 10, 88–93 (2013)

7 Rasool, M. et al. Evaluation of antimicrobial activity of ethanolic extracts of Azadirachta indica and Psidium guajava against clinically important bacteria at varying pH and temperature . 28, 1–6 (2017)

8 Shah, I., Jarullah, J., Jaouni, S. Al, Jamal, M. S. & Jarullah, B. Higher prevalence of glucose-6-phosphate dehydrogenase ( G6PD ) deficiency in tribal population against urban population : a signal to natural selection . 28, 1–4 (2017)

9 Sheikh, I. A. et al. Computational insights into the molecular interactions of environmental xenoestrogens 4-tert-octylphenol, 4- nonylphenol, bisphenol A (BPA), and BPA metabolite, 4-methyl-2, 4-bis (4-hydroxyphenyl) pent-1-ene (MBP) with human sex hormone-binding globulin. Ecotoxicol. Environ. Saf. 135, 284–291 (2017)

10 SA Bayesian Model for the Prediction and Early Diagnosis of Alzheimer’s Disease Athanasios Alexiou1*, Vasileios D. Mantzavinos 1, 2, Nigel H. Greig3 and Mohammad A. Kamal 1, 4, 5

11 A comprehensive review on biological properties of citrinin José Williams G. de Oliveria Filho, Muhammad Torequl Islam, Eunus S. Ali, Shaikh Jamal Uddin, Jose Victor de Oliveira Santos, Marcus Vinícius Oliveira Barros de Alencar, Antonio Luiz Gomes Júnior, Márcia Fernanda Correia Jardim Paz, Maria dos Remédios Mendes de Brito, João Marcelo de Castro e Sousa, Subrata Shaw, Maria das Graças Freire de Medeiros, Sandra Maria Mendes de Moura Dantas, Hercília Maria Lins Rolim, Paulo Michel Pinheiro Ferreira, Mohammad Amjad Kamal, Magdalena D. Pieczynska, Niranjan Das, Vijai K. Gupta, Andrei Mocan, Teresinha de Jesus Aguiar dos Santos Andrade, Brahma Nand Singh, Siddhartha K. Mishra, Atanas G. Atanasov, Ana Amélia de Carvalho Melo-Cavalcante

12 A multidimensional integration analysis reveals potential bridging targets in the process of colorectal cancer liver metastasis Bo Gao1,2?, Tian Yu3?, Dongbo Xue1?, Boshi Sun4?, Qin Shao2, Hani Choudhry5, Victoria Marcus2, Jiannis Ragoussis6, Yuguo Zhang7, Weihui Zhang1, Zu-hua Gao2*

13 A Putative Association of Interleukin-10 Promoter Polymorphisms with Cardiovascular Disease Shams Tabrez 1* Murtaza Ali2 Nasimudeen R. Jabir1 Chelapram K. Firoz1 Ghulam Md. Ashraf1 Salwa Hindawi3 Ghazi A. Damanhouri1 Mohammed Nabil Alama4

14 ?A review on nanoantimicrobials metal nanoparticles

15 Acoustic and hybrid 3D-printed electrochemical biosensors for the real-time immunodetection of liver cancer cells (HepG2) Samar Damiatia,b,c,?, Seta Küpcüb, Martin Peacockd, Christoph Eilenbergerb, Mazin Zamzamia,c, Ishtiaq Qadrie, Hani Choudhrya,c,f, Uwe B. Sleytrg, Bernhard Schusterb

16 ?Adipose,BoneMarrowandSynovialJoint-DerivedMesenchymalStemCellsforCartilageRepair Christopher R.Fellows 1, CsabaMatta1, 2, RozaZakany2, IlyasM.Khan3 and Ali Mobasheri1, 4,5,6*

17 Alopecia Areata and Medical Modulation of the Intrinsic Property of Melanin to Transform Light Into Chemical Energy Through the Water Dissociation Arturo Solís Herrera1, Martha Patricia Solís-Arias1, Vadim V. Tarasov2, Ghulam Md Ashraf3, Gjumrakch Aliev4,5,6,*

18 Alzheimer’s Disease and Natural Products: Future Regimens Emerging From Nature Article in Current Topics in Medicinal Chemistry · January 2017

19 Amelioration of hyperglycaemia and modulation of antioxidant status by Alcea rosea seeds in alloxan-induced diabetic rats Parvaiz A. Dar, Fasil Ali, Ishfaq A. Sheikh, Showkat A. Ganie & Tanveer A. Dar

20 Ameliorative effects of L-carnitine on rats raised on a diet supplemented with lead acetate El-Said El-Sherbini a, Gehad El-Sayed a, Rehab El Shotory a, Nervana Gheith b, Mohamed Abou-Alsoud c, Steve Mustapha Harakeh f, Gamal I. Karrouf d,e,

21 AMPK expression patterns are significantly associated with poor prognosis in breast cancer patients Jaudah Al-Maghrabia, Kaltoom Al-Sakkafb, Imtiaz Ahmad Qureshic, Nadeem Shafique Buttd, Lila Damnhoryb, Mohamed Elshale, Basim Al-Maghrabif, Alia Aldahlawig, Sawsan Ashoorh, Barry Browni, Pauline Dobsoni, Mohamad Nidal Khabazc,?

22 An Anti-Cancer Drug Candidate OSI-027 and its Analog as Inhibitors of mTOR: Computational Insights Into the Inhibitory Mechanisms Mohd Rehan * King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Kingdom of Saudi Arabia

23 An insight on the association of glycation with hepatocellular carcinoma Nasimudeen R. Jabira, Saheem Ahmadb, Shams Tabreza,? a King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia

24 Antibacterial Applications of Anatase TiO 2 Nanoparticle

25 Anti-cancer effects of Ajwa dates (Phoenix dactylifera L.) in diethylnitrosamine induced hepatocellular carcinoma in Wistar rats Fazal Khan1,2, Tariq Jamal Khan1, Gauthaman Kalamegam2* , Peter Natesan Pushparaj2, Adeel Chaudhary3, Adel Abuzenadah3, Taha Kumosani1,4, Elie Barbour1,5 and Mohammed Al-Qahtani2

26 Antimicrobial activity of iron oxide nanoparticles against Klebsiella pneumoniae and Bacillus cereus,

27 Antimicrobial effect of different types of honey on Staphylococcus aureus Saad B. Almasaudi a, Alaa A.M. Al-Nahari a, El Sayed M. Abd El-Ghany b, Elie Barbour c,d, Saad M. Al Muhayawi e, Soad Al-Jaouni f, Esam Azhar g, Mohamad Qari f, Yousef A. Qari h, Steve Harakeh g,*

28 ‘Arcanobacterium urinimassiliense’ sp. nov., a new bacterium isolated from the urogenital tract K. Diop1, A. Morand1,2, J. C. Dubus2, P.-E. Fournier1, D. Raoult1,3 and F. Fenollar1

29 Application of high rate integrated anaerobic-aerobic/biogranular activated carbon sequencing batch reactor (IAnA-BioGACSBR) for treating strong municipal landfill leachate Meghdad Pirsaheb1, Hooshyar Hossini1, Marius Sebastia Secula2, Molouk Parvaneh3 & Ghulam Md Ashraf 4

30 “Arthrobacter saudimassiliensis” sp. nov. a new bacterial species isolated from air samples in the urban environment of Makkah, Saudi Arabia Anastasia Papadioti, Esam Ibraheem Azhar, Fehmida Bibi, Asif Jiman-Fatani, Sally M. Aboushoushah, Muhammad Yasir, Didier Raoult, Emmanouil Angelakis

31 Assessment of IL-18 Serum Level and its Promoter Polymorphisms in the Saudi Coronary Artery Disease (CAD) Patients† Nasimudeen R. Jabir1, Chelapram K. Firoz1, Mohammad A. Kamal1, Ghazi A. Damanhouri1, Mohammed Nabil Alama2, Qamre Alam1, Absarul Haque1, Hussein A Almehdar3, Shams Tabrez1*

32 Atomic structures of fibrillar segments of hIAPP suggest tightly mated b-sheets are important for cytotoxicity Pascal Krotee1,2,3,4*, Jose A Rodriguez1,2,4, Michael R Sawaya1,2,4, Duilio Cascio1,2,4, Francis E Reyes5, Dan Shi5, Johan Hattne5, Brent L Nannenga5, Marie E Oskarsson6, Stephan Philipp7, Sarah Griner1,2,4, Lin Jiang3,8,9, Charles G Glabe7,10, Gunilla T Westermark6, Tamir Gonen5, David S Eisenberg1,2,3,4*

33 Bacteria from marine sponges: A source of new drugs

34 ‘Bacteroides ihuae’ sp. nov., a new bacterial species isolated from the human respiratory microbiome M. D. M. Fonkou1, A. Morand1, P.-E. Fournier1, D. Raoult1,2 and G. Dubourg1

35 Begomovirus infection on Cucumber in Saudi Arabia Sayed Sartaj Sohrab*, Muhammad Yasir, Sherif Ali El-Kafrawy

36 Biomarkers for Alzheimer’s Disease Diagnosis Vasileios Mantzavinosa, Athanasios Alexiou*,b, Nigel H. Greig1 and Mohammad A. Kamal2,3

37 Biophysical insights into the interaction of hen egg white lysozyme with therapeutic dye clofazimine: modulation of activity and SDS induced aggregation of model protein Mohammad Rehan Ajmal, Sumit Kumar Chaturvedi, Nida Zaidi, Parvez Alam, Masihuz Zaman, Mohammad Khursheed Siddiqi, Saima Nusrat, Mohammad Sarwar Jamal, Mohamed H. Mahmoud, Gamal Badr & Rizwan Hasan Khan

38 ‘Bittarella massiliensis’ gen. nov., sp. nov. isolated by culturomics from the gut of a healthy 28-year-old man G. A. Durand1, P.-E. Fournier1, D. Raoult1,2 and S. Edouard1

39 Catha edulis Forsk. (Khat): Evaluation of its Antidepressant-like Activity Hassan Alfaifi, Siddig Ibrahim Abdelwahab1, Syam Mohan2, Manal Mohamed Elhassan Taha2, Sohier M. Syame2,3, Lamiaa A. Shaala4, Rashad Alsanosy1

40 Characterization of colchicine binding with normal and glycated albumin: In-vitro and molecular docking analysis Nayyar Rabbani, Shams Tabrez, Badar ul Islam, Md Tabish Rehman, Abdulrahman M. Alsenaidy, Mohamed F Alajmi, Rais Ahmad Khan, Mohammad A. Alsenaidy & Mohd Shahnawaz Khan

41 Chemical screening and development of novel gibberellin mimics Kai Jiang a,i, Hiroaki Shimotakahara a,i, Ming Luo b,i, Masato Otani a, Hidemitsu Nakamura a, Said Salama Moselhy c,d,e,f, Khalid Omer Abualnaja c,d, Abdulrahman Labeed Al-Malki c,d,e, Taha Abduallah Kumosani c,e,g, Nobutaka Kitahata a, Takeshi Nakano h, Masatoshi Nakajima a, Tadao Asami a,c,d,?

42 Commitment of Scaffold Proteins in the Onco-Biology of Human Colorectal Cancer and Liver Metastases after Oxaliplatin-Based Chemotherapy Deborah Rotoli 1,2, Manuel Morales 3,4, Julio Ávila 1, María del Carmen Maeso 5, María del Pino García 6, Ali Mobasheri 7,8 and Pablo Martín-Vasallo 1,*

43 Common Therapeutic Modalities Against Diabetes and Associated Cardiovascular Disease Nasimudeen R Jabir1, Chelapram Kandy Firoz1, Ghulam Md Ashraf1, Syed Kashif Zaidi2, Shazi Shakil2,3, Mohammad Amjad Kamal1,4,5 and Shams Tabrez

44 Comparative bacterial community analysis in relatively pristine and anthropogenically influenced mangrove.

45 Comparative study of extrapolative factors linked with oxidative injury and antiinflammatory status in chronic kidney disease patients experiencing cardiovascular distress Mahmood Rasool1, Muhammad Abdul Basit Ashraf2, Arif Malik2, Sulayman Waquar2, Shahida Aziz Khan3, Mahmood Husain Qazi4, Waseem Ahmad1, Muhammad Asif5, Sami Ullah Khan6, Ahmad Zaheer7, Muther Mansoor Qaisrani8, Abdul Rehman Khan9, Aamir Iqbal7, Amir Raza7, Saima Iram10, Kashif Kamran11, Asim Iqbal11, Mohammad Zahid Mustafa12, Hani Choudhry13, Mazin A. Zamzami14, Wesam H. Abdulaal14, Mohammad Sarwar Jamal

46 Comparative study of fatty-acid composition of table eggs from the Jeddah food market and effect of value addition in omega-3 bio-fortified eggs Shahida Aziz Khan a,*, Aziz Khan a, Sarah A. Khan b, Mohd Amin Beg c, Ashraf Ali a, Ghazi Damanhouri

47 Computing disease-linked SOD1 mutations: deciphering protein stability and patient-phenotype relations Vijay Kumar1, Safikur Rahman 2, Hani Choudhry3, Mazin A. Zamzami4, Mohammad Sarwar Jamal5, Asimul Islam 1, Faizan Ahmad1 & Md. Imtaiyaz Hassan

48 Conditioned Medium of Human Adipose Mesenchymal Stem Cells Increases Wound Closure and Protects Human Astrocytes Following Scratch Assay In Vitro Eliana Baez-Jurado1 & Oscar Hidalgo-Lanussa1 & Gina Guio-Vega1 & Ghulam Md Ashraf2 & Valentina

49 ‘Corynebacterium fournierii,’ a new bacterial species isolated from the vaginal sample of a patient with bacterial vaginosis K. Diop1, F. Bretelle1,2, D. Raoult1,3 and F. Fenollar1

50 Cures of Vascular Disease – The State

51 Current and emerging biomarkers in tumors of the central nervous system: Possible diagnostic, prognostic and therapeutic applications Ishaq N. Khana,d, Najeeb Ullahb, Deema Husseinc,??, Kulvinder S. Sainid,

52 Current opinion in Alzheimer’s disease therapy by nanotechnology-based approaches Shakeel Ahmed Ansaria, Rukhsana Satarb, Asma Perveenc, and Ghulam Md Ashraf

53 Current Views on Neurodegeneration: Computational to Clinical Research Girish Kumar Gupta1 and Mohammad Amjad Kamal2,3,4,*

54 Cyclic and linear siloxanes in indoor air from several northern cities in Vietnam: Levels, spatial distribution and human exposure Tri Manh Tran a, *, Hanh Thi Le a, Nam Duc Vu b, Giang Huong Minh Dang a, Tu Binh Minh a, Kurunthachalam Kannan c, d

55 Cyclin D1 expression is associated with stage, grade and survival in urinary bladder carcinoma Mohamad Nidal Khabaz1, Abdelbaset Buhmeida2, Tawfik Ghabrah3, Imtiaz Ahmad Qureshi1, Nadeem Shafique Butt3, Basim Al-Maghrabi4, Taoufik Nedjadi5, Mohmmad Al-Qahtani2, Jaudah Al-Maghrabi6

56 Dakarella massiliensis gen. nov., sp. nov., strain ND3T: a new bacterial genus isolated from the female genital tract N. Dione1, J. Rathored1, E. Tomei1, J.-C. Lagier1, S. Khelaifia1, C. Robert1, F. Bretelle1,2, D. Raoult1,3, P.-E. Fournier1 and F. Fenollar1

57 DARPins Bioengineering and its Theranostic Approaches: Emerging Trends in Protein Engineering Mahmood Rasool1,*, Arif Malik2, Mubashir Hussain2, Kalsoom A. Haq2, Kiran Butt2, Abdul Basit2, Muhammad Imran Naseer1, Muhammad Asif3, Rozena Shaikh3, Mohammad Zahid Mustafa4, Qamre Alam5, Ghulam Rasool6, Waseem Ahmad1, Absarul Haque5 and Mohammad Amjad Kamal5,7

58 Description of “Arabia massiliensis” gen. nov, sp. nov., “Gordonibacter massiliensis” sp. nov., and “Bacilliculturomica massiliensis” gen.nov, sp. nov., isolated from a fecal specimen of a 50 year-old Saudi Bedouin female Sory Ibrahima Traore, Esam Ibraheem Azhar, Muhammad Yasir, Fehmida Bibi, Pierre-Edouard Fournier, Asif Ahmad Jiman-Fatani, Jeremy Delerce, Frédéric Cadoret, Jean-Christophe Lagier, Didier Raoult

59 Description of “Beduinibacterium massiliense” gen.nov, sp. nov., “Massilimaliae massiliensis” gen.nov, sp. nov., “Provencibacterium massiliense” gen. nov, sp. nov., and “Oscilibacter massiliensis” sp.nov., isolated from a fecal specimen of a 19-yearold healthy Saudi Arabia Bedouin by culturomics Sory Ibrahima Traore, Esam Ibraheem Azhar, Muhammad Yasir, Fehmida Bibi, Pierre-Edouard Fournier, Asif Ahmad Jiman-Fatani, Jeremy Delerce, Frédéric Cadoret, Jean-Christophe Lagier, Didier Raoult

60 Description of “Blautia phocaeensis” sp.nov., and “Lachnoclostridium edouardi” sp. nov., isolated from healthy fresh stools of Saudii Arabia bedouins by culturomics Sory Ibrahima Traore, Esam Ibraheem Azhar, Muhammad Yasir, Fehmida Bibi, Pierre-Edouard Fournier, Asif Ahmad Jiman-Fatani, Jeremy Delerce, Frédéric Cadoret, Jean-Christophe Lagier, Didier Raoult

61 Detection and Genotyping of Helicobacter pylori among Gastric ulcer and Cancer Patients from Saudi Arabia Fehmida Bibi1, Sana Akhtar Alvi2, Sara Ali Sawan3, Muhammad Yasir4, Ali Sawan5, Asif A. Jiman-Fatani6, Esam I. Azhar7

62 Determination of 89 drugs and other micropollutants in unfiltered wastewater and freshwater by LC-MS/MS: an alternative sample preparation approach Alexandros G. Asimakopoulos1,2 & Pranav Kannan2 & Sean Higgins2 & Kurunthachalam Kannan2,3,4

63 Dietary Changes with Omega-3 Fatty Acids Improves the Blood Lipid Profile of Wistar Albino Rats with Hypercholesterolaemia Shahida A Khan*, and Ahmad Makki

64 Diversity and bioprospecting potential of rhizo and endophytic bacteria from two mangrove plants in Saudi Arabia Fehmida Bibi1*, Ikram Ullah2, Sana Akhtar1, Muhammad Yasir1, Eman Ahmed Kensarah1, Ahmed Abdullah Khalaf Al-Ghamdi3, Esam I. Azhar1,3

65 Diversity of antagonistic bacteria isolated from medicinal plant Peganum harmala L. Fehmida Bibi *

66 Draft Genome Sequence of Agrococcus baldri Strain Marseille-P2731 Pamela Afouda,a Gregory Dubourg,a Noemie Labas,a Didier Raoult,a,b Pierre-Edouard Fourniera

67 Edible Vaccine: Current Status and Future Perspectives Sayed Sartaj Sohrab1,*, Mohd. Suhail2, Mohammad A. Kamal2,3,4, Azamal Husen6 and Esam I. Azhar1,5 Fehmida Bibi *

68 Draft Genome Sequence of Agrococcus baldri Strain Marseille-P2731 Pamela Afouda,a Gregory Dubourg,a Noemie Labas,a Didier Raoult,a,b Pierre-Edouard Fourniera

69 Edible Vaccine: Current Status and Future Perspectives Sayed Sartaj Sohrab1,*, Mohd. Suhail2, Mohammad A. Kamal2,3,4, Azamal Husen6 and Esam I. Azhar1,5 Fehmida Bibi *

70 Effect of Indole-3-Butyric Acid on Clonal Propagation of Mulberry (Morus alba L.) Stem Cuttings: Rooting and Associated Biochemical Changes Azamal Husen1 • Muhammad Iqbal2 • Shadab Naseer Siddiqui2 • Sayed Sartaj Sohrab3 Getinet Masresha1

71 Effects of Honey on Oral Mucositis among Pediatric Cancer Patients Undergoing Chemo/Radiotherapy Treatment at King Abdulaziz University Hospital in Jeddah, Kingdom of Saudi Arabia Soad K. Al Jaouni,1,2 Mohammad S. AlMuhayawi,1 Abear Hussein,1 Iman Elfiki,1 Rajaa Al-Raddadi,3 Saad M. Al Muhayawi,4 Saad Almasaudi,5,6 Mohammad Amjad Kamal,2,6,7,8 and Steve Harakeh2,9

72 Effects of ZD7288, a hyperpolarization-activated cyclic nucleotidegated (HCN) channel blocker, on term-pregnant rat uterine contractility in vitro Mohammed Alotaibi a, *, Karima Kahlat b, Taoufik Nedjadi c, Laiche Djouhri a

73 Effects of Short Term Supplementation of Fish Oil Capsules on the Blood Fatty Acid Profile of Vegetarians: A Pilot Study Shahida A Khan1*, Hegde MV2, Wagh UV2 and Rehana Jamadar2

74 Electron Microscopy of Alkhumra Hemorrhagic Fever Virus Tariq A. Madani,1,2 El-Tayb M.E. Abuelzein,2,3 Sawsan M. Jalalah,4 Huda Abu-Araki,2,5 Esam I. Azhar,2,3,6 Ahmed M. Hassan,2,3 and Hussein M.S. Al-Bar2,7

75 elucidating treatment of alzhemiers disease via

76 Endocrine disruption: In silico interactions between phthalate plasticizers and corticosteroid binding globulin Ishfaq A. Sheikh | Mohd A. Beg

77 Epidermal hydrogen peroxide is not increased in lesional and non-lesional skin of vitiligo Mohammad Z. Zailaie1

78 Estimation of Interleukin-1b Promoter (?? 31 C/T and ?? 511 T/C) Polymorphisms and Its Level in Coronary Artery Disease Patients Shams Tabrez ,1* Nasimudeen R. Jabir,1 Chelapram K. Firoz,1 Salwa Hindawi,2 Shazi Shakil ,3,4 Ghazi A. Damanhouri,1 and Syed Kashif Zaidi3

79 Ethnicity and skin autofluorescence-based risk-engines for cardiovascular disease and diabetes mellitus Muhammad Saeed Ahmad1,2?*, Torben Kimhofer2?*, Sultan Ahmad1, Mohammed Nabil AlAma3, Hala Hisham Mosli4, Salwa Ibrahim Hindawi5, Dennis O. Mook-Kanamori6, KatarõÂnaSÏ ebekovaÂ7, Zoheir Abdullah Damanhouri1,8, Elaine Holmes1,2

80 European Network for Neglected Vectors and Vector-Borne Infections COST Action Guidelines: What Is This About and What Is This For? Remi N. Charrel,1,2 Laetitia Lempereur,3 Andrei D. Mihalca,4 and Muriel Vayssier-Taussat5

81 Evaluation of Anti-Inflammatory Properties of Isoorientin Isolated from Tubers of Pueraria tuberosa Kotha Anilkumar,1,2 Gorla V. Reddy,1 Rajaram Azad,1 Nagendra Sastry Yarla,3 Gangappa Dharmapuri,1 Anand Srivastava,2 Mohammad A. Kamal,4,5,6 and Reddanna Pallu1

82 Evaluation of Cytological and Genetic Effects of Tribulus terrestris Fruit Aqueous Extract on Cultured Human Lymphocytes Sameer H. Qari, S.M. El-Assouli

83 Evaluation of the antiproliferative and cytotoxic activities of marine invertebrates-derived fungi

84 Evaluation of the antiproliferative and cytotoxic activities of marine invertebrates-derived fungi Abdulrahman M Alahdal1, Lamiaa A Shaala2,3, Ahmad O Noor1, Mahmoud A Elfaky4, Sameh S Elhady4, Ameen Almohammadi1, Alaa Bagalagel1, Manar O Lashkar1, Diena M Almasri1 and Diaa TA Youssef4,5

85 Exacerbation of N-nitrosodiethylamine Induced Hepatotoxicity and DNA Damage in Mice Exposed to Chronic Unpredictable Stress Nayeem Bilal1, Nida Suhail1,2, Shirin Hasan1,3, Ghulam M. Ashraf4, Sabiha Fatima5, Husain Y. Khan1, Mariam S. Alharbi6, Athanasios Alexiou7* and Naheed Banu1,6*

86 Exploring the interaction between Mycobacterium tuberculosisEnolase and human plasminogen using computational methods and experimental techniques† Running head: Interaction of Mtb Enolase with Human Plasminogen Amit Rahi1,#, Alisha Dhiman1,#, Damini Singh1, Andrew M. Lynn3,**, Mohd. Rehan2,**, Rakesh Bhatnagar1,*

87 Expression of p-AMPK is associated with hormone receptor phenotypes and lymph node metastasis in breast cancer Mohamad Nidal Khabaz1, Kaltoom Al-Sakkaf2, Imtiaz Ahmad Qureshi1, Nadeem Shafique Butt3, Lila Damnhory2, Mohamed Elshal4, Basim Al-Maghrabi5, Alia Aldahlawi6, Sawsan Ashoor7, Barry Brown8, Pauline Dobson8, Jaudah Al-Maghrabi9

88 Fabrication, optimization, and characterization of umbelliferone ß-D-galactopyranoside-loaded PLGALGALGA nanoparticles in treatment of hepatocellular carcinoma: in vitro and in vivo studies Vikas Kumar,1 Prakash Chandra Bhatt,2 Mahfoozur Rahman,1 Gaurav Kaithwas,3 Hani Choudhry,4,5 Fahad A Al-Abbasi,4 Firoz Anwar,4 Amita Verma6

89 Familial Alzheimer’s disease mutations within the amyloid precursor protein alter the aggregation and conformation of the amyloid beta peptide. Asa Hatami1,2, Sanaz Monjazeb1, Saskia Milton1, and Charles G. Glabe1,3

90 First Complete Genome Sequence of Circulating Dengue Virus Serotype 3 in Jeddah, Saudi Arabia Anwar M. Hashem, Sayed S. Sohrab, Sherif A. El-Kafrawy, Saeid Abo El-Ela, Adly MM. Abd-Alla, Suha A. Farraj, Norah A. Othman, Ahmed M. Hassan, Mai M. El-Daly, Remi N. Charrel, Tariq A. madani, Esam I. Azhar

91 Frontier View on Drug Discoveries for Different Diseases - Part I

92 Frontier View on Drug Discoveries for Different Diseases - Part II

93 Frontier Views in Designing Therapeutic Candidates for Management of Diverse Diseases Mohammad A. Kamal1,2,3 and Nigel H. Greig4

94 Galectins-Potential Target for Cardiovascular Therapy Ghulam Md Ashraf 1,*, Asma Perveen2, Syed Kashif Zaidi3, Ausaf Ahmad4, Shazi Shakil5,6, Chelapram Kandy Firoz1, Nasimudeen R. Jabir1, Iftekhar Hassan7, Taqi Ahmad Khan8, Nagendra Sastry Yarla9, Shams Tabrez1,*

95 Garlic Extract Attenuates Immobilization Stress-Induced Alterations in Plasma Antioxidant/Oxidant Parameters and Hepatic Function in Rats Syed Kashif Zaidi1, Shakeel Ahmed Ansari1, Shams Tabrez2, Md Nasrul Hoda3, Ghulam Md. Ashraf2, Mohd Shahnawaz Khan4, Sultan Alnohair5, Naheed Banu6, and Mohammed Hussain Al-Qahtani1

96 geneticts of ovarian hyperstimulation syndrome

97 Genome analysis of Chlamydia trachomatis for functionalcharacterization of hypothetical proteins to discover novel drugtargetsAhmad Abu Turab Naqvia,1, Safikur Rahmanb,1, Rubia, Firdaus Zeyac, Kundan Kumara,Hani Choudharyd, Mohammad Sarwar Jamale, Jihoe Kimb,*, Md. Imtaiyaz Hassana,*

98 Genome sequence and description of Anaeromassilibacillus senegalensis gen. nov., sp. nov., isolated from the gut of patient with kwashiorkor E. Guilhot1, M. T. Alou1, J.-C. Lagier1, N. Labas1, C. Couderc1, J. Delerce1, A. Diallo2,3, C. Sokhna2,3, P.-E. Fournier1, D. Raoult1,2,3,4 and S. Khelaifia

99 Genomic analysis of a Streptococcus pyogenes strain causing endocarditis in a child M. Beye1, K. El Karkouri1, N. Labas1, D. Raoult1,2 and P.-E. Fournier1

100 Genomic answers for recurrent spontaneous abortion in Saudi Arabia: An array comparative genomic hybridization approach$ Sajjad Karima,*, Hasan Salleh Jamalb, Abdullraheem Rouzib, Mohammed Salleh M. Ardawic, Hans-Juergen Schultena, Zeenat Mirzad, Nuha A. Alansaria, Maha M. Al-Quaitia, Heba Abusamraa, Muhammad Imran Naseera, Rola Turkib,e, Adeel Gulzar Chaudharya, Mamdooh Garia, Adel Mohammed Abuzenadaha,e, Mohammed Hussain Al-Qhatania,*

101 Gingerenone A attenuates monocyte-endothelial adhesion via suppression of I Kappa B kinase phosphorylation† Hee Joo Kim1,2,†, Joe Eun Son1,2,†, Jae Hwan Kim1,2,†, Charles C. Lee3, Hee Yang1,2, Soonham Sami Yaghmoor4, Youssri Ahmed5, Jehad Mustafa Yousef6, Khalid Omer Abualnaja7, Abdulrahman Labeed Al-Malki8, Taha Abdullah Kumosani9, Jung Han Yoon Park1,2, Chang Yong Lee3,10,*, Jong-Eun Kim2,11,* and Ki Won Lee1,2,*

102 Gliomas New Perspectives in Diagnosis, Treatment and Prognosis

103 Halomonas saudii’ sp. nov., a new bacterial species isolated from marine plant Halocnemum strobilaceum F. Bibi1, M. Yasir1, S. A. Alvi1, E. I. Azhar1,2, A. A. K. Al-Ghamdi2, A. M. Abuzenadah3,4, D. Raoult5 and E. Angelakis5

104 Histological, immunohistochemical and ultrastructural study of secondary compressed spinal cord injury in a rat model Wafaa S. Ramadan1, 2, 3, Ghada A. Abdel-Hamid1, 2, 4, Saleh Al-Karim2, 5, Aymn T. Abbas6, 7

105 “HTLV-1 Associated Neurological Disorders” Muhammad Yasir Khan1, Ishaq Nasib Khan2,3, Muhammad Farman2, Saleh Al karim2,4, Ishtiaq Qadri4, Muhammad Amjad Kamal5, Khalid Al Ghamdi2 and Steve Harakeh5,*

106 Hugonella massiliensis gen. nov., sp. nov., genome sequence, and description of a new strictly anaerobic bacterium isolated from the human gut Ziena Elsawi1,* | Amadou Hamidou Togo1,* | Mamadou Beye1 | Grégory Dubourg1 | Claudia Andrieu1 | Nicholas Armsrtong1 | Magali Richez1 | Fabrizio di Pinto1 | Fadi Bittar1 | Noémie Labas1 | Pierre-Edouard Fournier1 | Didier Raoult1,2 | Saber Khelaifia1

107 Identification of Human Leukocyte Antigen (HLA) Patterns in Beta-Thalassemia Patients and their Relevance to the Mutational Spectrum of the Human Beta-Globin Gene (HBB) Aisha Elaimi1,2, Abdullah Alraddadi1,2,5*, Sawsan Abuzinadah1, Asma Alaidaroos1, Ashraf Dallol1, Mohammed Y Saka3, Heba Alkhatabi2,4, Abdulkarim Alraddadi, Adel M Abuzenadah1,2,4

108 Immunogenicity of Candidate MERS-CoV DNA Vaccines Based on the Spike Protein Sawsan S. Al-amri1, Ayman T. Abbas1,2, Loai A. Siddiq1, Abrar Alghamdi1, Mohammad A. Sanki3, Muhanna K. Al-Muhanna4, Rowa Y. Alhabbab1,5, Esam I. Azhar1,5, Xuguang Li6 & Anwar M. Hashem1,7 Saber Khelaifia1

109 Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis

110 In silico analysis of glycinamide ribonucleotide transformylase inhibition by PY873, PY899 and DIA Sidra Batool a, Muhammad Sulaman Nawaz a, Gohar Mushtaq b, Fahed Parvaiz a, Mohammad A. Kamal c,*

111 Inediibacterium massiliense gen. nov., sp. nov., a new bacterial species isolated from the gut microbiota of a severely malnourished infant Maryam Tidjani Alou . Jaishriram Rathored . Caroline Michelle . Gregory Dubourg . Claudia Andrieu . Nicholas Armstrong . Cheikh Sokhna . Aldiouma Diallo . Didier Raoult . Pierre-Edouard Fournier

112 Infectious Agents and Neurodegenerative Diseases: Exploring the Links Mohammad Zubair Alam1, Qamre Alam1, Mohammad Amjad Kamal2,3, Asif Ahmad Jiman-Fatani4,5, Esam I. Azhar6,7, Mohammad Azhar Khan8 and Absarul Haque1,*

113 Insulin Resistance in Alzheimer's Disease p53 and MicroRNAs as Important players

114 “Intestinimonas massiliensis” sp. nov, a new bacterium isolated from human gut G. Durand1,3, P. Afouda1, D. Raoult1,2,3 and G. Dubourg1,3

115 Investigation of gut microbial communities associated with indigenous honey bee (Apis mellifera jemenitica) from two different eco-regions of Saudi Arabia Khalid Ali Khan a, Mohammad Javed Ansari a,?, Ahmad Al-Ghamdi a, Adgaba Nuru a, Steve Harakeh b,c, Javaid Iqbal a

116 Isolation and molecular characterization of mycotoxigenic fungi in agarwood Rashad R. Al-Hindi a, Soher E. Aly b, Amal S. Hathout b, Mona G. Alharbi a, Saad Al-Masaudi a, Soad K. Al-Jaouni c, Steve M. Harakeh d

117 Isolation, diversity, and biotechnological potential of rhizo- and endophytic bacteria associated with mangrove plants from.

118 ‘Jeotgalicoccus saudimassiliensis’ sp. nov., a new bacterial species isolated from air samples in the urban environment of Makkah, Saudi Arabia A. Papadioti1, E. I. Azhar2,3, F. Bibi2, A. Jiman-Fatani4, S. M. Aboushoushah2, M. Yasir2, D. Raoult1,2 and E. Angelakis1

119 “Khelaifiella massiliensis”, “Niameybacter massiliensis” “Brachybacterium massiliense” “Enterobacter timonensis”, “Massilibacillus massiliensis”, new bacterial species and genera isolated from the gut microbiota of healthy infants Maryam Tidjani Alou, Frederic Cadoret, Souleymane Brah, Aldiouma Diallo, Cheikh Sokhna, Vicky Mehrej, Jean-Christophe Lagier, Pierre-Edouard Fournier, Didier Raoult

120 ‘Lysinibacillus saudimassiliensis’ sp. nov., a new bacterial species isolated from air samples in the urban environment of Makkah, Saudi Arabia A. Papadioti1, E. I. Azhar2,3, F. Bibi2, A. Jiman-Fatani4, S. M. Aboushoushah2, M. Yasir2, D. Raoult1,2 and E. Angelakis1

121 Management of Alzheimer’s disease—An insight of the enzymatic and other novel potential targets Badar ul Islama, Shams Tabrezb

122 Manuka Honey Exerts Antioxidant and Anti-Inflammatory Activities That Promote Healing of Acetic Acid-Induced Gastric Ulcer in Rats Saad B. Almasaudi,1 Aymn T. Abbas,2,3 Rashad R. Al-Hindi,1 Nagla A. El-Shitany,4,5 Umama A. Abdel-dayem,6 Soad S. Ali,7 RashaM. Saleh,8 Soad K. Al Jaouni,9 Mohammad Amjad Kamal,10,11 and Steve M. Harakeh12

123 Marseillibacter massiliensis gen. nov., sp. nov., a new bacterial genus isolated from the human gut S. Ndongo1, G. Dubourg1, F. Bittar1, C. Sokhna2, P.-E. Fournier1 and D. Raoult1,3

124 Mass loading and emission of benzophenone-3 (BP-3) and its derivatives in wastewater treatment plants in New York State, USA WeiWang a, Kurunthachalam Kannan a,b

125 Mass loading and removal of benzotriazoles, benzothiazoles, benzophenones, and bisphenols in Indian sewage treatment plants Rajendiran Karthikraj a, Kurunthachalam Kannan a, b, c, *

126 Mass loading and removal of pharmaceuticals and personal care products including psychoactives, antihypertensives, and antibiotics in two sewage treatment plants in southern India Bikram Subedi a, b, Keshava Balakrishna a, c, *, Derrick Ian Joshua c, Kurunthachalam Kannan a, d, **

127 Maternal and neonatal outcomes in twin and triplet gestations in Western Saudi Arabia Samera F. AlBasri, MD, Ghadah M. Shouib, MD, Osama S. Bajouh, MD, Hasan A. Nasrat, MD, Ejaz Ahmad, MSc, Fahad M. AlGreisi, MD.

128 Metabolic Phenotype of Obesity in a Saudi Population Muhammad Saeed Ahmad,*,† Munirah Alsaleh,‡ Torben Kimhofer,‡ Sultan Ahmad,† Wisam Jamal,§ Siraj Omar Wali,? Jeremy Kirk Nicholson,‡ Zoheir Abdullah Damanhouri,†,? and Elaine Holmes

129 Metformin attenuate PTZ-induced apoptotic neurodegeneration in human cortical neuronal cells Fehmida Bibi1, Ikram Ullah2, Myeong Ok Kim3, Muhammad Imran Naseer4

130 Mitochondrial Permeability Transition Pore as a Suitable Targ e t for Neuroprotective Agents Against Alzheimer’s Disease

131 Multiple renal cancer susceptibility polymorphisms modulate the HIF pathway Steffen Grampp1?, Virginia Schmid2?, Rafik Salama2?, Victoria Lauer1, Franziska Kranz1,3, James L. Platt2, James Smythies2, Hani Choudhry4, Margarete Goppelt-Struebe1, Peter J. Ratcliffe2³*, David R. Mole2³*, Johannes SchoÈ del1³*

132 Nanofiber Scaffold Coated with Ag and ZnO Nanoparticles for Treatment of Methicillin Resistant Staphylococcus

133 Nanotechnology for Alzheimer Disease

134 Neisseria meningitidis nasopharyngeal carriage during the Hajj: A cohort study evaluating the need for ciprofloxacin prophylaxis Ziad A. Memish a,b,c,?, Jaffar A. Al-Tawfiq d,e, Malak Almasri a, Esam I. Azhar f,g, Muhammad Yasir f, Muneera S. Al-Saeed f, Huda Ben Helaby f, Ray Borrow h, Abdulhafeez Turkistani a, Abdallah Assiri

135 Noncontiguous finished genome sequence and description of Fusobacterium massiliense sp. nov. isolated from human duodenum M. Mailhe1, D. Ricaboni1,3, V. Vitton2, A. Benezech2, G. Dubourg1, C. Michelle1, C. Andrieu1, N. Armstrong1, F. Bittar1, P.-E. Fournier1, D. Raoult1,4 and M. Million1

136 Noncontiguous finished genome sequence and description of Prevotella phocaeensis sp. nov., a new anaerobic species isolated from human gut infected by Clostridium difficile P. Afouda1, S. Ndongo1, S. Khelaifia1, N. Labas1, F. Cadoret1, F. Di Pinto1, J. Delerce1, D. Raoult1,2 and M. Million1

137 Noncontiguous finished genome sequence and description of Streptococcus timonensis sp. nov. isolated from the human stomach D. Ricaboni1,3, M. Mailhe1, J.-C. Lagier1, C. Michelle1, N. Armstrong1, F. Bittar1, V. Vitton2, A. Benezech2, D. Raoult1,4 and M. Million1

138 Noncontiguous finished genome sequences and description of Bacillus massiliglaciei, Bacillus mediterraneensis, Bacillus massilinigeriensis, Bacillus phocaeensis and Bacillus tuaregi, five new species identified by culturomics F. Cadoret1, M. T. Alou1, P. Afouda1, I. S. Traore1, L. Bréchard1, C. Michelle1, F. Di Pinto1, C. Andrieu1, J. Delerce1, A. Levasseur1, P.-E. Fournier1 and D. Raoult1,2

139 Occurrence of and exposure to benzothiazoles and benzotriazoles from textiles and infant clothing Wenbin Liu a,b, Jingchuan Xue a, Kurunthachalam Kannan a,c,?

140 Occurrence of benzotriazoles (BTRs) in indoor air from Albany, New York, USA, and its implications for inhalation exposure Jingchuan Xue, Yanjian Wan & Kurunthachalam Kannan

141 Occurrence of phthalate diesters in indoor air from several Northern cities in Vietnam, and its implication for human exposure Tri Manh Tran a,?, Hanh Thi Le a, Tu BinhMinha, Kurunthachalam Kannan

142 Of phlebotomines (sandflies) and viruses: a comprehensive perspective on a complex situation Nazli Ayhan1 and Remi N Charrel

143 Olegusella massiliensis gen. nov., sp. nov., strain KHD7T, a new bacterial genus isolated from the female genital tract of a patient with bacterial vaginosis Khoudia Diop a, Awa Diop a, Florence Bretelle a, b, Frederic Cadoret a, Caroline Michelle a, Magali Richez a, Jean-François Cocallemen b, Didier Raoult a, c, Pierre-Edouard Fournier a, Florence Fenollar a, *

144 Optimization Of Alkaline ?-Amylase Production By Thermophilic Bacillus Subtilis Nuha Bakeet Al-Johani 1, Madeha N. Al-seeni1, Youssri Mohamed Ahmed1,2,3*

145 Optimization of Glucose Powered Biofuel Cell Anode Developed by Polyaniline-Silver as Electron Transfer Enhancer and Ferritin as Biocompatible Redox Mediator Sufia ul Haque1, Inamuddin2,3, Abu Nasar1, B. Rajender 1, Anish Khan2,3, Abdullah M. Asiri2,3 & Ghulam Md Ashraf 4

146 Pacaella massiliensis gen. nov., sp. nov., a new bacterial species isolated from the human gut S. Ndongo1, G. Dubourg1, P.-E. Fournier1 and D. Raoult1,2

147 Optimization of expression and purification of human mortalin (Hsp70): Folding/unfolding analysis Mohd Shahnawaz Khan a,?, Anwar Ahmed a, Shams Tabrez b, Badar ul Islamc, Nayyar Rabbani a, Ajamaluddin Malik a, Mohamad A. Ismael a, Mohammad A. Alsenaidy d, Abdulrahman M. Alsenaidy a

148 Paenibacillus phocaensis sp. nov., isolated from the gut microbiota of a healthy infant M. Tidjani Alou1, J. Rathored1, T. T. Nguyen1, C. Andrieu1, C. Couderc1, S. Brah2, B. A. Diallo3, P.-E. Fournier1, D. Raoult1,4 and G. Dubourg1

149 Patterns of Human Respiratory Viruses and Lack of MERS-Coronavirus in Patients with Acute Upper Respiratory Tract Infections in Southwestern Province of Saudi Arabia Ahmed A. Abdulhaq,1,2 Vinod Kumar Basode,1 AnwarM. Hashem,3,4 Ahmed S. Alshrari,5 Nassrin A. Badroon,3 AhmedM. Hassan,3 Tagreed L. Alsubhi,3 Yahia Solan,6 Saleh Ejeeli,1 and Esam I. Azhar3,7

150 phage display technique a novel medicinal approach to overcome

151 “Phoenicibacter massiliensis” gen. nov., sp. nov. , a new bacterium isolated from the human gut of a pygmy woman Melhem Bilen, Frédéric Cadoret, Gregory Dubourg, Pierre-Edouard Fournier, Ziad Daoud, Didier Raoult

152 Photocatalytic degradation of Aniline from aqueous solutions under sunlight illumination using immobilized Cr:ZnO nanoparticles Meghdad Pirsaheb1, Behzad Shahmoradi 2,3, Masumeh Beikmohammadi4, Esmaeel Azizi4, Hooshyar Hossini5 & Ghulam Md Ashraf

153 “Phylogenetic characterization of circulating Dengue and Alkhumra Hemorrhagic Fever viruses in western Saudi Arabia and lack of evidence of Zika virus in the region: A retrospective study, 2010-2015 Moneerah S. Al-Saeed1 | Sherif A. El-Kafrawy1 | Suha A. Farraj1 | Tagreed L. Al-Subhi1 | Norah A. Othman1 | Arwa Alsultan1 | Huda G. Ben Helaby1 | Mustafa M. Alshawdari1 | Ahmed M. Hassan1 | Remi N. Charrel1,2,3 | Esam I. Azhar1,4 | Anwar M. Hashem1,5

154 Pleomorphism and drug resistant cancer stem cells are characteristic of aggressive primary meningioma cell lines Ishaq Khan1,2,3,4, Saleh Baeesa5, Mohammed Bangash5, Hans-Juergen Schulten3, Fahad Alghamdi6, Hanadi Qashqari1, Nawal Madkhali4, Angel Carracedo3,7, Mohamad Saka1, Awatif Jamal6, Jaudah Al-Maghrabi6, Mohammed AlQahtani3, Saleh Al-Karim1,2, Ghazi Damanhouri1, Kulvinder Saini2,8, Adeel Chaudhary3,4, Adel Abuzenadah3,4 and Deema Hussein1

155 Point Mutations in the DNA Binding Domain of p53 Contribute to Glioma Progression and Poor Prognosis1 P. P. Sarmaa, D. Duttab, Z. Mirzac, K. Kr. Saikiaa, *, and B. Kr. Baishyab

156 Possible Hypocholesterolemic Effect Of Ginger And Rosemary Oils In Rats Fatma A. Eissa1, Hani Choudhry1,5,6, Wesam H. Abdulaal1,6, Othman A. Baothman1, Mustafa Zeyadi1, Said S. Moselhy1,2,3,4, Mazin A. Zamzami1,5,6

157 Possible Molecular Interactions of Bexarotene — A Retinoid Drug and Alzheimer’s Aß Peptide: A Docking Study Zeenat Mirza* and Mohd Amin Beg

158 Possible Regulation Of Ldl-Receptor By Naringenin In Hepg2 Hepatoma Cell Line Nora A. Bawazeer1, Hani Choudary2, Mazin A. Zamzami3, Wesam H. Abdulaal3, Mustafa Zeyadi3, Ashwag ALbukhari3, Bruce Middleton4 and Said S Moselhy5,6,7

159 potential linkage between cerebrovascular diseases and metabolic syndrome

160 Presence of Anticardiolipin Antibodies in Patients with Dementia: A Systematic Review and Meta-Analysis Md. Asiful Islam1*, Fahmida Alam1, Mohammad Amjad Kamal2,3,4, Siew Hua Gan1, Teguh Haryo Sasongko5 and Kah Keng Wong6

161 Prevalence and molecular characterization of hepatitis D virus in Saudi Arabia: A single-center study Ghazi A. Jamjoom1, Mai M. El-Daly1, Esam I. Azhar1,2, Hind I. Fallatah3, Hisham O. Akbar3, Mohammed Babatin4, Abdullah S. Alghamdi5, Mohammed I. Dgdgi6, Mohamed A. Hamid7,8, Yousef A. Qari9, Sherif A. El-Kafrawy1

162 Protective Role Of Carnitine Synergized With Vitamin E Against Isoproterenol Induced Cardiac Infarction In Rats. Etimad A. Huwait1,2*, Maryam A. Al-Ghamdi 1,2

163 protein-protein interaction PPI network recent advances in drug

164 Proteomic analysis of naturally occurring boron tolerant plant Gypsophila sphaerocephala L. in response to high boron concentration Huseyin Tombuloglua, Guzin Tombuloglua, Mehmet Serdal Sakcalib, Ali Turkanc, Khalid Rehman Hakeemd,?, Hesham F. Alharbyd, Shah Fahde, Waseem Mohammed Abduld

165 ‘Pseudomonas saudimassiliensis’ sp. nov. a new bacterial species isolated from air samples in the urban environment of Makkah, Saudi Arabia E. I. Azhar1,2, A. Papadioti3, F. Bibi1, A. M. Ashshi4, D. Raoult1,3 and E. Angelakis3

166 Pseudomonas saudiphocaensis’ sp. nov., a new bacterial species isolated from currency notes collected during the Hajj pilgrimage in 2012 at Makkah, Saudi Arabia E. I. Azhar1,2, A. Papadioti3, F. Bibi1, A. M. Ashshi4, D. Raoult1,3 and E. Angelakis3

167 ‘Ramadan fasting in Saudi Arabia is associated with altered expression of CLOCK, DUSP and IL-1alpha genes, as well as changes in cardiometabolic risk factors Ghada M. A. Ajabnoor1,2, Suhad Bahijri1,2*, Noor Ahmad Shaik3,4, Anwar Borai2,5, Aliaa A. Alamoudi1,2, Jumana Y. Al-Aama2,3,4, George P. Chrousos2,6

168 recent advances in drug delivery of polymeric nano-micelles

169 Recent advances in the development of novel protein scaffolds based therapeutics Asim Azhara,*,1, Ejaj Ahmada,1, Qamar Ziaa,b,1, Mohd. Ahmar Raufa, Mohammad Owaisa, Ghulam Md Ashrafc,*

170 Recent updates on molecular genetic engineering approaches and applications of human therapeutic proteins

171 Recent Updates on the Application of Protein-Protein Interaction Network in Drug Discovery Alexiou Athanasios1*, Vairaktarakis Charalampos2, Tsiamis Vasileios2 and Ghulam Md Ashraf 3,*

172 Reduction in CD16/CD56 and CD16/CD3/CD56 Natural Killer Cells in Coronary Artery Disease Nasimudeen R. Jabir, Chelapram K. Firoz, Farid Ahmed, Mohammad A. Kamal, Salwa Hindawi, Ghazi A. Damanhouri, Hussein A. Almehdar & Shams Tabrez

173 Repertoire of human gut microbes Perrine Hugon a, Jean-Christophe Lagier b, Philippe Colson b, Fadi Bittar b, Didier Raoult b, c, *

174 Review and Recommendations on Management of Adult Female Thalassemia Patients with Hypogonadism based on Literature Review and Experience of ICET-A Network Specialists Vincenzo De Sanctis1, Ashraf T. Soliman2, Heba Elsedfy3, Alice Albu4, Soad Al Jaouni5, Salvatore Anastasi6, Maria Grazia Bisconte7, Duran Canatan8, Soteroula Christou9, Shahina Daar10, Salvatore Di Maio11, Mohamed El Kholy3, Doaa Khater12, Mohamed Elshinawy13 ,Yurdanur Kilinc14, Roberto Mattei15, Hala H. Mosli16, Alessandra Quota17, Maria Grazia Roberti18, Praveen Sobti19, Saif AL Yaarubi20, Saveria Canpisi21 and Christos Kattamis22

175 Rubeoparvulum massiliense gen. nov., sp. nov., a new bacterial genus isolated from the human gut of a Senegalese infant with severe acute malnutrition M. Tidjani Alou1, J. Rathored1, J.-C. Lagier1,2,3, S. Khelaifia1, C. Michelle1, C. Sokhna2, A. Diallo2, A. B. Diallo4, P.-E. Fournier1, D. Raoult1,5 and S. Edouard1

176 Saudi Moumouvirus, the First Group B Mimivirus Isolated from Asia Leena H. Bajrai1,2, Felipe L. de Assis3, Esam I. Azhar4, Priscilla Jardot2, Catherine Robert2, Jônatas Abrahão2,3, Didier Raoult2 and Bernard La Scola2*

177 Seroprevalence of Asymptomatic Dengue Virus Infection and Its Antibodies Among Healthy/Eligible Saudi Blood Donors: Findings From Holy Makkah City Ahmed M Ashshi1, Saad Alghamdi1, Adel G El-Shemi1,2, Sabir Almdani3, Bassem Refaat1, Amr M Mohamed1,4, Hani O Ghazi5, Esam I Azhar6 and Faisal A Al-Allaf7

178 Signaling Pathways Regulated By Brassicaceae Extract Inhibit The Formation Of Advanced Glycated End Products In Rat Brain Abdulrahman L. Al-Malki1,2,3,Elie K. Barbour3,4, Huwait EA1,2,5 Said S. Moselhy1,2,3,6 Anas Hassan Saeed ALZahrani 7and Taha A. Kumosani1,3,8

179 Simultaneous determination of brominated and phosphate flame retardants in flame-retarded polyester curtains by a novel extraction method Yuichi Miyake a, Masahiro Tokumura a, Hayato Nakayama a, QiWang a, Takashi Amagai a,?, Sayaka Ogo b, Kazunari Kume c, Takeshi Kobayashi d, Shinji Takasu e, Kumiko Ogawa e, Kurunthachalam Kannan

180 Synopsis on Managment Strategies for Neurodegenerative Disorders: Challenges from Bench to Bedside in Successful Drug Discovery and Development Sheraz Ahmad Bhat1, Mohammad Amjad Kamal2,3,4, Nagendra Sastry Yarla5 and Ghulam Md Ashraf2,

181 Synthesis and Characterization of Cefotaxime Conjugated Gold Nanoparticles and Their Use to Target Drug-Resistant CTX-M-Producing Bacterial Pathogens Sibhghatulla Shaikh,1 Syed Mohd. Danish Rizvi,2* Shazi Shakil,3,4** Talib Hussain,2 Thamir M. Alshammari,5,6 Waseem Ahmad,3 Shams Tabrez,7 Mohammad H. Al-Qahtani,3 and Adel M. Abuzenadah

182 Synthesis of Saccharumoside-B analogue with potential of antiproliferative and pro-apoptotic activities Srinuvasarao Rayavarapu1, Nagendra Sastry Yarla2,3, Sunanda Kumari Kadiri4, Anupam Bishayee5, Siddaiah Vidavalur1, Ramu Tadikonda1, Mahaboob Basha1, Vijaya Rao Pidugu6, Kaladhar S. V. G. K. Dowluru7, Dhananjaya Bhadrapura Lakappa8, Mohammad A. Kamal9,10, Ghulam Md Ashraf9, Vadim V. Tarasov11, Vladimir N. Chubarev11, Sergey G. Klochkov12, George E. Barreto13,14, Sergey O. Bachurin12 & Gjumrakch Aliev

183 Synthesis, screening and pro-apoptotic activity of novel acyl spermidine derivatives on human cancer cell lines Syed Shoeb Razvia, Hani Choudhrya,b,c,e, Said Salama Moselhya,d,e,f, Taha Abduallah Kumosania,d,g, Mohammed Nihal Hasana, Mazin A. Zamzamia,b,c, Khalid Omer Abualnajaa,d,e, Abdulrahman Labeed Al-Malkia,d,e, Mahmoud Alhosina,b,c,1,** , Tadao Asami

184 Taxonogenomics and description of Vaginella massiliensis gen. nov., sp. nov., strain Marseille P2517T, a new bacterial genus isolated from the human vagina K. Diop1, F. Bretelle2, C. Michelle1, M. Richez1, J. Rathored1, D. Raoult1,3, P.-E. Fournier1 and F. Fenollar1

185 The challenges of cholera at the 2017 Hajj pilgrimage

186 The diabetic brain and cognition Peter Riederer1, Amos D. Korczyn16, Sameh S. Ali2, Ovidiu Bajenaru3, Mun Seong Choi4, Michael Chopp5,Vesna Dermanovic-Dobrota7, Edna Gru¨nblatt8,9,10, Kurt A. Jellinger11, Mohammad Amjad Kamal13,14,15, Warda Kamal12, Jerzy Leszek17, Tanja Maria Sheldrick-Michel19, Gohar Mushtaq20, Bernard Meglic18, Rachel Natovich6, Zvezdan Pirtosek21 , Martin Rakusa22 , Melita Salkovic-Petrisic23, Reinhold Schmidt24 , Angelika Schmitt25, G. Ramachandra Sridhar26 , La´szlo´ Ve´csei27 , Zyta Beata Wojszel28 , Hakan Yaman29 , Zheng G. Zhang5,29 , Tali Cukierman-Yaffe

187 The epigenetic integrator UHRF1: on the road to become a universal biomarker for cancer

188 The Relationship between Ultraviolet, Vitamin D and Blood Glucose, in Vivo Study Asma Bukharia*, Faten Khorshidb

189 The Role of S-Palmitoylation of the Human Glucocorticoid Receptor (hGR) in Mediating the Nongenomic Glucocorticoid Actions Nicolas C. Nicolaides1,2 Tomoshige Kino3, Michael L. Roberts1, Eleni Katsantoni4, Amalia Sertedaki2, Paraskevi Moutsatsou5, Anna-Maria G. Psarra6, George P. Chrousos1,2,7 and Evangelia Charmandari1,2

190 Thrombotic Management of Antiphospholipid Syndrome: Towards Novel Targeted Therapies

191 Tomato Leaf Curl Sudan Virus (TLCSDV) causing leaf curl disease on a new host Amaranthus cruentus L. Sayed Sartaj Sohrab

192 Type 3 diabetes mellitus a novel implication of Alzheimer’s disease

193 Urinary levels of triclosan and triclocarban in several Asian countries, Greece and the USA: Association with oxidative stress Archana P. Iyera,b,c,d, Jingchuan Xuee, Masato Hondae, Morgan Robinsone, Taha Abdullah Kumosania,b,d, Khalid Abulnajaa,f, Kurunthachalam Kannana

194 “Vaginella massiliensis” gen. nov., sp. nov., a new genus cultivated from human female genital tract K. Diop1, O. Mediannikov1, D. Raoult1,2, F. Bretelle1,3 and F. Fenollar1

195 Value Added Eggs Seem a Good Option for Improving Blood Omega-6: Omega-3 Ratio and Heart Health Shahida A. Khan1*, MV Hegde2, UV Wagh2, Aziz Khan2, and Rehana Jamadar2

196 Viral Infection and Obesity: Current Status and Future Prospective Sayed Sartaj Sohrab1*, Mohammad A. Kamal2, 3, 4, Richard L. Atkinson5, Maha M. Alawi6, Esam I. Azhar1,7

197 ß-Thalassemia Distribution in the Old World: an Ancient Disease Seen from a Historical Standpoint Vincenzo De Sanctis1, Christos Kattamis2, Duran Canatan3, Ashraf T. Soliman4 , Heba Elsedfy5, Mehran Karimi6, Shahina Daar7, Yasser Wali8, Mohamed Yassin9, Nada Soliman10, Praveen Sobti11, Soad Al Jaouni12, Mohamed El Kholy5, Bernadette Fiscina13 and Michael Angastiniotis14

198 A novel WDR62 mutation causes primary microcephaly in a large consanguineous Saudi family Muhammad Imran Naseer,a Mahmood Rasool,a Sameera Sogaty,b Rukhaa Adeel Chaudhary,c Haifa Mansour Mansour,c Adeel G. Chaudhary,a Adel M. Abuzenadah,a Mohammad H. Al-Qahtania

199 A Targetable EGFR-Dependent Tumor-Initiating Program in Breast Cancer

200 Advances and Implications in Nanotechnology for Lung Cancer Management Sana Sarkara , Khwaja Osama a , Qazi Mohammad Sajid Jamal b , Mohammad Amjad Kamalc,d,e, Usman Sayeed a , M. Kalim A. Khan a , Mohd. Haris Siddiqui a and Salman Akhtar

201 Alzheimer's Disease: From Molecular Mechanisms to Psychobiological Perspectives

202 An ICET- A survey on hypoparathyroidism in patients with thalassaemia major and intermedia: a preliminary report Vincenzo De Sanctis1 , Ashraf T. Soliman2 , Duran Canatan3 , Heba Elsedfy 4, Mehran Karimi5 , Shahina Daar6 , Hala Rimawi7 , Soteroula Christou 8, Nicos Skordis9 , Ploutarchos Tzoulis10, Praveen Sobti11, Shruti Kakkar12, Yurdanur Kilinc13, Doaa Khater14, Saif A Alyaarubi 5, Valeriya Kaleva16, Su Han Lum17, Mohamed A Yassin18, Forough Saki19, Maha Obiedat20, Salvatore Anastasi 21, Maria Concetta Galati 22, Giuseppe Raiola23, Saveria Campisi24 , Nada Soliman25, Mohamed Elshinawy26, Soad Al Jaouni27, Salvatore Di Maio28,Yasser Wali29, Ihab Zaki Elhakim30, Christos Kattamis3

203 Analysis of bacterial communities and characterization of antimicrobial strains from cave microbiota Muhammad Yasir

204 Analysis of SNPs of MC4R , GNB3 and FTO gene polymorphism in obese Saudi subjects. Said Salama Moselhy1,4,6,7*, Yasmeen A Alhetari1 , Archana Iyer1,4,5, Etimad A Huwait1 , Maryam A AL-Ghamdi1 , Shareefa AL-Ghamdi1 , Khadijah Saeed Balamash1 , Ashraf A Basuni2,8, Mohamed N Alama3 , Taha A Kumosani1,4,5, Soonham Sami Yaghmoor4,5

205 Anthocyanins: Possible role as Multitarget therapeutic agents for prevention and therapy of chronic diseases Swathi Putta1,+ , Nagendra Sastry Yarla2,# , Ilaria Peluso3,+ , Dinesh Kumar Tiwari4,+ , GorlaV.Reddy4 , , Priyanka Voori Giri4 , Naresh Kumar4 , Ramarao Malla2 , Veera Brahma Chari5 , Rama Sekhara Reddy D5 , Ramesh Bade2 , Mastan Mannarapu6 , George Barretto7 , Da-Yong Lu8 , Vadim V. Tarasov9 , Vladimir N. Chubarev9 , Frederico Fávaro Ribeiro10 , Luciana Scotti*11, Marcus T. Scotti11, M.A.Kamal12, Gjumrakch Aliev13,$ , Chinthalapally V. Rao14 , Anupam Bishayee15,!

206 Arab Women in Science, Technology, Engineering and Mathematics Fields: The Way Forward Samira I. Islam1,*

207 Assessment of chemotherapy on various biochemical markers in breast cancer patients† Márcia Fernanda Correia Jardim Paz1 , Antonio Luiz Gomes Júnior1 , Muhammad Torequl Islam2 , Shams Tabrez3* , Nasimudeen R Jabir2 , Mohammad Zubair Alam2 , Kátia da Conceição Machado2 , Marcus Vinícius Oliveira Barros de Alencar2 , Keylla da Conceição Machado2 , Eunus S. Ali4 , Siddhartha Kumar Mishra5 , Leonardo Fortes Gomes2, João Marcelo de Castro e Sousa2 , Geane Felix de Souza2 , Ana Amélia de Carvalho Melo-Cavalcante2 , Juliana da Silva

208 Assessment of genetic diversity in IL-6 and RANTES promoters and their level in Saudi coronary artery disease patients Nasimudeen R. Jabir1 | Chelapram K. Firoz1 | Mohammad A. Kamal1 | Ghazi A. Damanhouri1 | Mohammed Nabil Alama2 | Anas S. Alzahrani3 | Hussein A. Almehdar4 | Shams Tabrez

209 Association of Interleukin-6 and Other Cytokines with Self-Reported Pain in Prostate Cancer Patients Receiving Chemotherapy Sarah Al-Mazidi, MSC,*,¶ Karim Farhat, PhD,† TaoufiK Nedjadi, PhD,‡ Adeel Chaudhary, PhD,§ Osman Zin Al-Abdin, MSc,† Danny Rabah, MBBS,† Mohammad Al-Zoghaibi, PhD,* and Laiche Djouhri, PhD,*

210 Association of Tomato leaf curl Sudan virus with leaf curl disease of Squash in Saudi Arabia , Sayed Sartaj Sohrab

211 Bacillus kwashiorkori sp. nov., a new bacterial species isolated from a malnourished child using culturomics El hadji Seck1 | Mamadou Beye1 | Sory Ibrahima Traore1 | Saber Khelaifia1 | Caroline Michelle1 | Carine Couderc1 | Souleymane Brah2 | Pierre-Edouard Fournier1 | Didier Raoult1,3 | Fadi Bittar1

212 Bio-Catalytic Structural Transformation of Anti-cancer Steroid, Drostanolone Enanthate with Cephalosporium aphidicola and Fusarium lini, and Cytotoxic Potential Evaluation of Its Metabolites against Certain Cancer Cell Lines M. Iqbal Choudhary 1, 2, 3 *, Mahwish Siddiqui 1 , Atia-tul-Wahab2 , Sammer Yousuf 1 , Narjis Fatima2 , Malik S. Ahmad1 and Hani Choudhry 3, 4

213 Biological activity of Cymbopogon schoenanthus essential oil Gasal M. Hashim b , Saad B. Almasaudi a , Esam Azhar b,c , Soad K. Al Jaouni d , Steve Harakeh b,

214 Biologically active compounds from the red sea sponge Suberea sp. Lamiaa A Shaala1,2* and Ameen Almohammadi3

215 Biosensors: Classifications, medical applications, and future prospective Hani A. Alhadrami

216 Bisphenols, Benzophenones, and Bisphenol A Diglycidyl Ethers in Textiles and Infant Clothing Jingchuan Xue,† Wenbin Liu,‡ and Kurunthachalam Kannan

217 Blocking of cytokines signalling attenuates evoked and spontaneous neuropathic pain behaviours in the paclitaxel rat model of chemotherapy-induced neuropathy S. Al-Mazidi1,2, M. Alotaibi1 , T. Nedjadi3 , A. Chaudhary4 , M. Alzoghaibi1 , L. Djouhri1

218 Changes in erythrocyte ATPase activity under different pathological conditions. Ali A Kherd1 , Nawal Helmi1,2, Khadijah Saeed Balamash1 , Taha A Kumosani1,2,3, Shareefa A AL-Ghamdi1 , Qari M4 , Etimad A Huwait1 , Soonham S Yaghmoor2,3, Alaama Nabil5 , Maryam A AL-Ghamdi1 , Said S Moselhy1,2,6,7

219 Comprehensive molecular biomarker identifcation in breast cancer brain metastases Hans-Juergen Schulten1* , Mohammed Bangash2 , Sajjad Karim1 , Ashraf Dallol1 , Deema Hussein3 , Adnan Merdad4 , Fatma K. Al-Thoubaity4 , Jaudah Al-Maghrabi5,6, Awatif Jamal5 , Fahad Al-Ghamdi5 , Hani Choudhry7 , Saleh S. Baeesa2 , Adeel G. Chaudhary1 and Mohammed H. Al-Qahtani

220 Congenital factor VII deficiency in Hirschsprung disease patient, a novel case report Galila M. Zaher a , Jummanah S. Jarullah b, * , Soheir S. Adam a , Mazen O. Kurdi a , Mohammad Sarwar Jamal b , Ghazi A. Damanhouri a,

221 Corrigendum to “Urinary biomarkers of exposure to 57 xenobiotics and its association with oxidative stress in a population in Jeddah, Saudi Arabia” [Environ. Res. 150 (2016) 573–581] Alexandros G. Asimakopoulosa,1 , Jingchuan Xuea,f,1 , Bruno Pereira DeCarvalhoa , Archana Iyerb , Khalid Omer Abualnajac , Soonham Sami Yaghmoord , Taha Abdullah Kumosanie , Kurunthachalam Kannana,e,f,?

222 Culturomics and Amplicon-based Metagenomic Approaches for the Study of Fungal Population in Human Gut Microbiota Ibrahim Hamad1,2, Stéphane Ranque 1, Esam I. Azhar3,4, Muhammad Yasir3, Asif A. Jiman-Fatani3,5, Hervé Tissot-Dupont1, Didier Raoult1 & Fadi Bittar

223 Sangeeta Saxena · A. K. Tiwari Editors Begomoviruses: Occurrence and Management in Asia and Africa

224 Decrypting the microRNA signatures in gastric cancer using high-throughput miRNA array coupled with systems biological approaches for precision medicine Fehmida Bibi1 , Peter Natesan Pushparaj2 , Muhammad I. Naseer2 , Muhammad yasir1 , Esam I. Azhar

225 Diabetes mellitus and male aging: Pharmacotherapeutics and clinical implications Article in Current Pharmaceutical Design · March 2017

226 Diversity, Physiochemical and Phylogenetic Analyses of Bacteria Isolated from Various Drinking Water Sources Neveen H. Eid1 , Huda A. Al Doghaither2 , Taha A. Kumosani3 , Munazza Gull4

227 Effect of Supplementation With Chitosan on Weight, Cardiometabolic, and Other Risk Indices in Wistar Rats Fed Normal and High-Fat/High-Cholesterol Diets Ad Libitum Suhad M Bahijri1,2, Lubna Alsheikh1,2, Ghada Ajabnoor1,2 and Anwar Borai2,3,4

228 Electrocatalytic Performance of Chemically Synthesized PIn-AuSGO Composite toward Mediated Biofuel Cell Anode Ruma Perveen1, Inamuddin2,3, Sufa ul Haque1, Abu Nasar1, Abdullah M. Asiri2,3 & Ghulam Md Ashraf 4

229 Epidural Analgesia During Childbirth: Women's Perspective in Saudi Arabia Hanan M. Shamrani1 , mbbs, abog, Arwa F. Shamrani2 , mbbs, Fai J. Almagrabi2 , mbbs, Safwan O. Tayeb2 , mbbs, Rahma S. Bukhari3 , pharm.d, and Steve M. Harakeh4 , phd

230 Evidence for a role of hemozoin in metabolism and gametocytogenesis Ghazi A. Jamjoom1*

231 Exome-wide association study of plasma lipids in >300,000 individuals

232 First Report of Tomato leaf curl Sudan virus Infecting Tomato Plants in Gujarat State, India B. Jarullah,† Department of Biotechnology, Kadi Sarva Vishwavidhyalaya, Gandhinagar, Gujarat, India; and S. S. Sohrab and J. S. Jarullah

233 Fournierella massiliensis, gen. nov., sp. nov., a new human-associated member of the family Ruminococcaceae

234 Genetic diversity of Croton Yellow Vein Mosaic Virus and betasatellites associated with yellow vein mosaic disease of Sida acuta in India Sayed Sartaj Sohrab*

235 Graphene Oxide Based Metallic Nanoparticles and their Some Biological and Environmental Application Aftab Aslam P. Khan1,2*, Anish Khan1,2, Abdullah M. Asiri1,2, Ghulam Md. Ashraf 3 and Basma G. Alhogbia 2

236 Gut microbiota associated with HIV infection is significantly enriched in bacteria tolerant to oxygen Grégory Dubourg,1,2 Jean-Christophe Lagier,1 Sophie Hüe,3,4,5,6 Mathieu Surenaud,3,4,5 Dipankar Bachar,1 Catherine Robert,1 Caroline Michelle,1 Isabelle Ravaux,7 Saadia Mokhtari,8 Matthieu Million,1,8 Andreas Stein7 Philippe Brouqui,1,8 Yves Levy,3,4,5,6,9 Didier Raoult,1,2,10

237 HCV genetics and genotypes dictate future antiviral strategies Louis Papageorgiou1,2, Chrisanthy Vlachakis3 , Konstantina Dragoumani3 , Sofia Raftopoulou4 , Dimitrios Brouzas5 , Nicolas C Nicolaides6,7, George P Chrousos6-8 , Evangelia Charmandari6,7, Vasileios Megalooikonomou9 and Dimitrios Vlachakis6,9

238 Identification of novel inhibitors against UDP-galactopyranose mutase to combat leishmaniasis Mohammad Kashif1,2 | Shams Tabrez1 | Atahar Husein1 | Mohd Arish1 | Ponnusamy Kalaiarasan3 | Partha P. Manna2 | Naidu Subbarao3 | Yusuf Akhter4 | Abdur Rub

239 Immunogenicity in protein and peptide based-therapeutics: An overview

240 Immunohistochemical staining of leptin is associated with grade, stage, lymph node involvement, recurrence, and hormone receptor phenotypes in breast cancer Mohamad Nidal Khabaz1 , Amer Abdelrahman1 , Nadeem Butt2 , Lila Damnhory3 , Mohamed Elshal4 , Alia M. Aldahlawi4 , Swsan Ashoor5 , Basim Al-Maghrabi6 , Pauline Dobson7 , Barry Brown7 , Kaltoom Al-Sakkaf3 , Mohmmad Al-Qahtani8 and Jaudah Al-Maghrab

241 Impact Of Aspartame Consumption On Neurotransmitters In Rat Brain ,Othman A.S. Baothman1 , Said S. Moselhy1,2,3,4 , Sharifah H. Al-Shehri1 and Abdulrahman L AL-Malki1,2,3*

242 Implication of prophetic variables and their role in the development of oral squamous cell carcinoma (OSCC). Saima Rubab Khan1 , Arif Malik1 , Muhammad Abdul Basit Ashraf1 , Sulayman Waquar1 , Shahzad Ahmad1 , Abdul Rehman Khan2 , Ahmad Zaheer3 , Aamir Iqbal3 , Mohammad Zahid Mustafa4 , Abdul Jabbar5 , Saima Siddiqui6 , Muhammad Asif7 , Rozeena Shaikh7 , Hani Choudhry8 , Mazin A. Zamzami8 , Mohammad Sarwar Jamal9 , Mahmood Rasool10*

243 Implications of farnesyltransferase and its inhibitors as a promising strategy for cancer therapy Authors: Sergey G. Klochkov, Margarita E. Neganova, Nagendra Sastry Yarla, Madhukiran Parvathaneni, Bechan Sharma, Vadim V. Tarasov, George Barreto, Sergey O. Bachurin, Ghulam Md Ashraf, Gjumrakch Aliev

244 In silico identification of genes involved in chronic metabolic acidosis Ishfaq A. Sheikha,? , Adeel Malikb , Sameera F.M. AlBasric , Mohd A. Bega

245 In vitro Antiglycation, Antioxidant and Antiproliferative Properties of Peptides Derived from Tryptic Hydrolysis of Soya Bean Abudukadeer Kuerban1*, Said S. Moselhy1,2,3,4, Hanaa Ghashlan1 , Taha A. Kumosani1,3,5 , Othman A. S. Baothman1 , Mustafa Zeyadi1 , Nawal Helmi1 , Tahani M. Alghamdi6 , Mazin A. Zamzami1 , Muqtadir Baig Mirza7 , Fareeduddin Quadri Syed7 , Furkhan Ahmed Mohammed7 , Abdulrahman L. AL-Malki1,2,3 and Khalid O. Abulnaja1,2,3

246 Inactivation of Middle East respiratory syndrome-coronavirus in human plasma using amotosalen and ultraviolet A light Salwa I. Hindawi,1,2 Anwar M. Hashem,3,4 Ghazi A. Damanhouri,2 Sherif A. El-Kafrawy,3,5 Ahmed M. Tolah,3 Ahmed M. Hassan,3 and Esam I. Azhar 3,6

247 Initial investigations of a combined photo-assisted water cleaner and thermal collector Usman Jamil Rajput a , Hani Alhadrami b, c , Faten Al-Hazmi d, e , Quiquan Guo a , Jun Yang a

248 Insights into the molecular mechanisms of stress and inflammation in ageing and frailty of the elderly ,Dimitrios Vlachakis1,2,3, Evangelia I Zacharaki1 , Eirini Tsiamaki4 , Maria Koulouri2 , Sofia Raftopoulou2,5, Louis Papageorgiou2,6 , George P Chrousos7,8,9, John Ellul4 and Vasileios Megalooikonomou1

249 Inventory, loading and discharge of synthetic phenolic antioxidants and their metabolites in wastewater treatment plants Wei Wang a , Kurunthachalam Kannan a, b, *

250 Lactoperoxidase, an Antimicrobial Milk Protein, as a Potential Activator of Carcinogenic Heterocyclic Amines in Breast Cancer ISHFAQ AHMAD SHEIKH1, ESSAM HUSSAIN JIFFRI 2, MOHAMMAD AMJAD KAMAL1, GHULAM MD ASHRAF1 and MOHD AMIN BEG1

251 LC-MS based identification of secondary metabolites from marine antagonistic endophytic bacteria Fehmida Bibi1* , Muhammad Imran Naseer2 , Muhammad Yasir1 , Ahmed Abdullah Khalaf Al-Ghamdi3 , Esam Ibrahim Azhar1,3

252 Levels of Zinc, Magnesium and Iron in Children with Attention Deficit Hyperactivity Disorder Shahida A Khan*

253 Mechanism of Formation of Chlorinated Pyrene during Combustion of Polyvinyl Chloride Yuichi Miyake,† Masahiro Tokumura,† Qi Wang,† Takashi Amagai,*,† Yuichi Horii,‡ and Kurunthachalam Kannan*,§

254 Meet Our Regional Editor Mohammad Amjad Kamal

255 Mesenchymal stem cell therapy of hepatocellular carcinoma in rats: Detection of cell homing and tumor mass by magnetic resonance imaging using iron oxide nanoparticles Mamdooh Faidah1, B–D, F, Abdulwahab Noorwali2, 3, A–C, F, Hazem Atta4, 5, A–F, Naushad Ahmed6, B–F, Hamid Habib7, A, D–F, Laila Damiati3, B–F, Najlaa Filimban3, B–D, Mihal Al-qriqri3, B–D, Soheir Mahfouz8, B–F, Mohamad Nidal Khabaz9, B–F

256 Microbial Enzymatic Degradation of Biodegradable Plastics Roohi1,*, Kulsoom Bano1 , Mohammed Kuddus2 , Mohammed R. Zaheer3 , Qamar Zia4 , Mohammed F. Khan3 , Ghulam Md. Ashraf5 , Anamika Gupta6 and Gjumrakch Aliev7,8,9,

257 Molecular and enzoinformatics perspectives of targeting Polo-like kinase 1 in cancer therapy Shazi Shakila,b,c,? , Mohammad H. Baigd , Shams Tabreze , Syed M. Danish Rizvif , Syed K. Zaidic , Ghulam M. Ashrafe , Shakeel A. Ansaric , Aftab Aslam Parwaz Khang,h , Mohammad H. Al-Qahtanic , Adel M. Abuzenadaha,c , Adeel G. Chaudharya,c

258 Molecular Identification And Growth Inhibition Of Some Human Pathogenic Bacteria Isolated From King Fahad General Hospital, Jeddah Maaly Hassan Ali1 , Fotoon Sayegh 1,2 , Samyah D. Jastaniah1 and Magda M. Aly1*

259 Molecular Interactions of Carcinogenic Aromatic Amines, 4-Aminobiphenyl and 4,4’-Diaminobiphenyl, with Lactoperoxidase – Insight to Breast Cancer Ishfaq Ahmad Sheikh, Mohd Amin Beg And Muhammad Yasir

260 Natural Compounds That Inhibit Protein Glycation: A Review For Recent Findings Abudukadeer Kuerban1* , Said Salama Moselhy1, 2, 3, 4 , Yaaser Q. Almulaiky5 , Syed Shoeb Razvi1 , Mohammed Nihal Hasan1 , Khalid Omar Abulnaja1, 2, 3 , Taha A. Kumosani 1, 2, 3 , Abdulrahman L-AL-Malki 1,

261 New paradigm in ankyrin repeats: Beyond protein-protein interaction module Zeyaul Islama,*, Raghavendra Sashi Krishna Nagampalli a, Munazza Tamkeen Fatima b, Ghulam Md Ashraf c,

262 Nigella sativa and Saudi Honey Diminish Infections and Improve the Survival in a Kostmann’s Syndrome Patient: Case Report Soad K. Al Jaouni1,2, Taher Halawa1,2, Abear Hussein1 , Salwa Al Najjar1 , Mohammad S. Almuhayawi3 , Steve Harakeh4

263 Nigella sativa oil protects against tartrazine toxicity in male rats Madeha N. Al-Seenia , Haddad A. El Rabeyb,c,? , Amani Mohammed Al-Hameda , Mazin A. Zamazamia,d

264 Novel, one-step synthesis of zwitterionic polymer nanoparticles via distillation-precipitation polymerization and its application for dye removal membrane G. P. Syed Ibrahim1, Arun M. Isloor1, Inamuddin2,3,4, Abdullah M. Asiri2,3, Norafqah Ismail5, Ahmed Fauzi Ismail5 & Ghulam Md Ashraf

265 Occurrence, Comparative Growth And Composition Of Tribulus Terrestris L. Under Variable In-Situ Water Stress Ihsanullah Daur1*, Zahid H. Shah1 , Muhammad Z. Ihsan2 , Shahzad Ali3 , Muhammad Waqas4 , Hafiz M. Rehman5 , Abdallah A. Al-Feel1 , Ali K. Elsafori1 And Sayed S. Sohrab6

266 Occurrence, Removal, and Environmental Emission of Organophosphate Flame Retardants/Plasticizers in a Wastewater Treatment Plant in New York State Un-Jung Kim,† Jung Keun Oh,† and Kurunthachalam Kannan

267 PeMtb: A Database of MHC Antigenic Peptide of Mycobacterium tuberculosis Qamar Zia1,2,# , Asim Azhar2,# , Shadab Ahmad2,# , Mohammad Afsar3 , Ziaul Hasan3 , Mohammad Owais2 , Mahfooz Alam3 , Shabab Akbar3 , Magdah Ganash4 , Ghulam Md Ashraf 5 , Swaleha Zubair6,* and Gjumrakch Aliev7,

268 Pharmacological validation of the anxiolytic, muscle relaxant and sedative like activities of Capsicum annuum in animal model Muhammad Jawad1 , Haroon Khan1 , Samreen Pervaiz2, Saud S. Bawazeer3, Tareq Abu-Izneid3, Muhammad Saeed2 and Mohammad Amjad Kamal4

269 Possible Cardioprotective Action Of Pomegranate Juice Punica Granatum And Propolis Against Myocardial Infarction Induced In Rats Ghadeer Turki Aloutaibi1 , Hanaa Gashlan1 , Said Salama Moselhy1, 2, 3, 4, Abdulrahman L. AlMalki1,2,3,* and Jehan A. Khan5

270 Potential Antioxidant and Anti-Proliferative Activities of Biologically Active Marine Algae Extracts Taha A. Kumosani1,2,3 , Khadijah Saeed Balamash1 , Hanaa Ghashlan1 , Youssri Ahmed Mohamed1,2,3,4 , Othman A. S. Baothman1 , Mustafa Zeyadi1 , Soonham Sami Yaghmoor2,3 , Areej H. Alyahiby2 , Rana R. AL-Rasheed2 , Wafa Y. Alturkistani2 , Tahani M. Alghamdi4 , Maryam H. AL-Zahrani1 and Said Salama Moselhy1

271 Protection by Classical and Vectored Vaccines against Endemic Velogenic Newcastle Disease in broiler Farms and Evaluation of a Developed Autogenous Vaccine against Predominant Genotype VI

272 Recent Development and Future Prospects of Plant-Based Vaccines Sayed Sartaj Sohrab1,*, Mohd. Suhail2 , Mohammad A. Kamal2,3,4, Azamal Husen6 and Esam I. Azhar

273 Role of omentin-1 and C-reactive protein in obese subjects with subclinical inflammation Eman M. Alissa a,b, *, Maisa’a M. Al-Salmi a , Nabeel A. Alama a , Gordon A. Ferns c

274 Standardization of a Protocol for Quantitive Evaluation of Anti-Aerosolized Influenza Virus Activity by Vapors of a Chemically-Characterized Essential oil Taha Kumosani1 , Youssef Obeid2 , Houssam Shaib2 , Khalid Abualnaja3 , Said Salama Moselhy4,5 , Archana Iyer6 , Rizwana Sultan7 , Asim Aslam7 , Ahsan Anjum7 and Elie Barbour8*

275 Studies on Performance, Immunity, and Safety of Broilers Vaccinated with Killed H9N2 Vaccine and Supplemented with Essential Oils of Mentofin® in Drinking Water Rizwana Sultan, DVM, PhD1 Asim Aslam, DVM, PhD1 Gulbeena Saleem, DVM, PhD1 Ahsan Anjum, DVM, PhD1 Werner Krull, B.Eng.2 Taha Kumosani, PhD3 Elie K. Barbour, PhD4 *

276 Supplementation with Oligonol, Prevents Weight Gain and Improves Lipid Profile in Overweight and Obese Saudi Females Suhad M. Bahijri1,2,*, Ghada Ajabnoor1,2, Gehan A. Hegazy1,2,4, Lubna Alsheikh2 , Mai Z. Moumena2,3, Bushra M. Bashanfar2,3 and Amal H. Alzahrani2,3

277 Susceptibility of Salmonella Serovars Recovered from Hospitalized Saudis to Commercial Drugs and to a Chemically and Safety-Characterized Essential Oil Blend Taha Kumosani1 , Elie K. Barbour2,*, Houssam Shaib3 , Ghassan Mahmoud3 , Roger Mazloum3 , Chibli Abou Assi3 , Archana Iyer4 , Soonham Yaghmoor5 , Areej Al Yahiby1 , Wafa Al Turkstani6 , Esam Azhar7 , Hasan AlTalhi8 , Ayman Abbas9 , Asif Fatani10, Jehad Yousef11, Steve Harakeh7 , and Muhammad Murtada3

278 Synthesis And Biological Evaluation Of Triazolyl Monastrol Analogues Using Cu-Catalyzed Click Chemistry Hani Mutlak A. Hassan,A* Iuliana Denetiu,A Kaltoom Sakkaf,A Khalid A. Khan,B Peter N. Pushparaj,C And Kalamegam Gauthamanc

279 Therapeutic Effects of Phytochemicals of Brassicaceae for Management of Obesity

280 Therapeutic Suppression of Nonsense Mutation: An Emerging Target in Multiple Diseases and Thrombotic Disorders

281 Trophic Magnification of Parabens and Their Metabolites in a Subtropical Marine Food Web Xiaohong Xue,†,‡ Jingchuan Xue,† Wenbin Liu,†,§ Douglas H. Adams,? and Kurunthachalam Kannan*

282 Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults

283 Efficient Inactivation Of Mers Coronavirus In Human Plasma CP327-A191-Ilovepdf-Compressed


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