kfmrc@kau.edu.sa

(25027 ,61453) 00966-12-695-2000

الأبحاث

المنشورات العلمية

مركز الملك فهد للبحوث الطبية هو مركز أبحاث رائد بنتاج علمي زاخر من عام 1981 م وحتى الان
* لعرض المنشورات العلمية يرجى اختيار سنة النشر

المنشورات العلمية لعام 2021

Updates on Molecular and Biochemical Development and Progression of Prostate Cancer Fahmy O, Alhakamy NA, Rizg WY, Bagalagel A, Alamoudi AJ, Aldawsari HM, Khateb AM, Eldakhakhny BM, Fahmy UA, Abdulaal WH, Fresta CG.
1



Preparation and characterization of a thioctic acid naNostructured lipid carrier to enhance the absorption profile and limit the nephrotoxicity associated with allopuriNol in the treatment of gout Abdulaal WH, Alhakamy NA, Hosny KM. 2



Untargeted Metabolic Profiling of Extracellular Vesicles of SARS-CoV-2-Infected Patients Shows Presence of Potent Anti- Inflammatory Metabolites Alzahrani FA, Shait Mohammed MR, Alkarim S, Azhar EI, El-Magd MA, Hawsawi Y, Abdulaal WH, Yusuf A, Alhatmi A, Albiheyri R, Fakhurji B. 3



Ceftriaxone and Melittin Synergistically Promote Wound Healing in Diabetic Rats Alhakamy NA, Caruso G, Eid BG, Fahmy UA, Ahmed OA, Abdel-Naim AB, Alamoudi AJ, Alghamdi SA, Sadoun HA, Eldakhakhny BM, Caraci F.
4



Development and Optimization of Luliconazole Spanlastics to Augment the Antifungal Activity against Candida albicans Alhakamy NA, Al-Rabia MW, Md S, Sirwi A, Khayat SS, AlOtaibi SS, Hakami RA, Al Sadoun H, Eldakhakhny BM, Abdulaal WH, Aldawsari HM.
5



Development and Optimization of Cinnamon Oil Nanoemulgel for Enhancement of Solubility and Evaluation of Antibacterial, Antifungal and Analgesic Effects against Oral Microbiota Hosny KM, Khallaf RA, Asfour HZ, Rizg WY, Alhakamy NA, Sindi AM, Alkhalidi HM, Abualsunun WA, Bakhaidar RB, Almehmady AM, Abdulaal WH. Oral health is a
6



Potential of Anti-Cancer Activity of Secondary Metabolic Products from Marine Fungi Noman E, Al-Shaibani MM, Bakhrebah MA, Almoheer R, Al-Sahari M, Al-Gheethi A, Radin Mohamed RM, Almulaiky YQ, Abdulaal WH.
7



Recent advances in lipid-engineered multifunctional nanophytomedicines for cancer targeting Handa M, Beg S, Shukla R, Barkat MA, Choudhry H, Singh KK.
8



Remodelin, a N acetyltransferase 10 (NAT10) inhibitor, alters mitochondrial lipid metabolism in cancer cells Dalhat MH, Mohammed MR, Ahmad A, Khan MI, Choudhry H.
9



Lipid/polymer-based nanocomplexes in nucleic acid delivery as cancer vaccines Beg S, Almalki WH, Khatoon F, Malik A, Afaq S, Choudhry H, Hafeez A, Rahman M, Akhter S. 10



Suppression of circulating AP001429.1 long non-coding RNA in obese patients with breast cancer Choudhry H, Hassan MA, AlMalki AL, AlSakkaf KA. 11



Paclitaxel and naringenin-loaded solid lipid nanoparticles surface modified with cyclic peptides with improved tumor targeting ability in glioblastoma multiforme Wang L, Wang X, Shen L, Alrobaian M, Panda SK, Almasmoum HA, Ghaith MM, Almaimani RA, Ibrahim IA, Singh T, Baothman AA. 12



In-Silico Study of Immune System Associated Genes in Case of Type-2 Diabetes With Insulin Action and Resistance, and/or Obesity Eldakhakhny BM, Al Sadoun H, Choudhry H, Mobashir M. 13



Targeting Post-Translational Modifications of the p73 Protein: A Promising Therapeutic Strategy for Tumors Omran Z, H Dalhat M, Abdullah O, Kaleem M, Hosawi S, A Al-Abbasi F, Wu W, Choudhry H, Alhosin M. 14



ArchR is a scalable software package for integrative single-cell chromatin accessibility analysis Granja JM, Corces MR, Pierce SE, Bagdatli ST, Choudhry H, Chang HY, Greenleaf WJ. 15



Structural insights of human N-acetyltransferase 10 and identification of its potential novel inhibitors Dalhat MH, Altayb HN, Khan MI, Choudhry H. 16



Compound C, a Broad Kinase Inhibitor Alters Metabolic Fingerprinting of Extra Cellular Matrix Detached Cancer Cells Mohammed MR, Alghamdi RA, Alzahrani AM, Zamzami MA, Choudhry H, Khan MI. 17



Prospective of nanoscale metal organic frameworks [NMOFs] for cancer therapy Mohammed MR, Ahmad V, Ahmad A, Tabrez S, Choudhry H, Zamzami MA, Bakhrebah MA, Ahmad A, Wasi S, Mukhtar H, Khan MI. 18



The Microbiome and Its Implications in Cancer Immunotherapy Choudhry H. 19



Anti-Hepatocellular Carcinoma Biomolecules: Molecular Targets Insights Juaid N, Amin A, Abdalla A, Reese K, Alamri Z, Moulay M, Abdu S, Miled N. 20



Phytotoxic evaluation of neonicotiNoid imidacloprid and cadmium alone and in combination on tomato (Solanum lycopersicum L.) Touzout N, Mehallah H, Moralent R, Moulay M, Nemmiche S. 21



Strigol1/albumin/chitosan nanoparticles decrease cell viability, induce apoptosis and alter metabolomics profile in HepG2 cancer cell line Al-Malki AL, Bakkar A, Huwait EA, Barbour EK, Abulnaja KO, Kumosani TA, Moselhy SS. 22



Serum heavy metals of passive smoker females and its correlation to bone biomarkers and risk of osteoporosis Banjabi AA, Kurunthachalam K, Kumosani TA, Abulnaja KO, Al-Malki AL, Moselhy SS. 23



Association of blood heavy metal levels with osteocalcin abnormality and incidence of osteoporosis in Saudi subjects Banjabi AA, Kannan K, Kumosani TA, Yousef JM, Abulnaja KO, Moselhy SS. 24



Association of trace elements abnormalities with thyroid dysfunction Al-Bazi MM, Kumosani TA, Al-Malki AL, Kannan K, Moselhy SS. 25



Rheumatic Heart Disease and Its Association with H. pylori Infection Aloutaibi GT, Al-Malki AL, Balgoon MJ, Bahaidarah SA, Moselhy SS. 26



Antiatherogenic Effects of Quercetin in the THP-1 Macrophage Model In Vitro, With Insights Into Its Signaling Mechanisms Using In Silico Analysis Huwait EA, Saddeek SY, Al-Massabi RF, Almowallad SJ, Pushparaj PN, Kalamegam G. 27



Epigenetic immunomodulatory effect of eugenol and astaxanthin on doxorubicin cytotoxicity in hormonal positive breast Cancer cells Fouad MA, Sayed-Ahmed MM, Huwait EA, Hafez HF, Osman AM. 28



Enhancement of Annexin V in response to combination of epigallocatechin gallate and quercetin as a potent arrest the cell cycle of colorectal cancer Al-Ghamdi MA, Al-Enazy A, Huwait EA, Albukhari A, Harakeh S, Moselhy SS. 29



Low clinical utility of testing for antiplatelet factor 4 in asymptomatic individuals after ChAdOx1 nCoV-19 vaccine Barefah AS, Radhwi OO, Alamri SS, Alahwal HM, Denetiu I, Almohammadi AT, Bahashwan SM, Qari MH, Algaissi A, Alamer E, Alhazmi A. 30



Dysregulation of miRNAs in DLBCL: Causative Factor for Pathogenesis, Diagnosis and Prognosis Alsaadi M, Khan MY, Dalhat MH, Bahashwan S, Khan MU, Albar A, Almehdar H, Qadri I. 31



The distribution of Duffy alleles and genotypes in a Western Saudi cohort Bawazir WM, Khogeer A, Ashour A, Sabbag M, Alserihi R, Felimban R, Hakami N, Altayar M, Mirza A, Elfayomi R, Shinawi T. 32



Web-based expert system with quick response code for beta-thalassemia management Banjar HR, Zaher GF, Almutiry HS, Alshamarni AS, Almouhana GI, Alahwal HM, Bahashwan S, Barefah AS, Alnajjar SA, Alharbi HM. 33



Improving detection rates of suspected acute transfusion reactions through active surveillance Badawi MA, Saaty R, Altayyari ST, Khalil R, Moria F, Zaher G, Alnajjar S, Hindawi SI. 34



Diagnosis and management of hematological manifestations of gaucher disease: Insights from Saudi Arabia Owaidah T, Alabbas F, Alhazmi I, Al Saeed H, Balelah S, ElYamany G, Kashari O, Qari M, Saleh M, Roushdy S, ElBagoury M. 35



The Prevalence of Depression and Anxiety Among Sickle Cell Disease Patients in King Abdulaziz University Hospital, Al-Marzouki AF, Alrefaie NI, Aljohani NA, Alandanusi RA, Alghamdi AA, Radhwi OO. 36



In vivo evidence: Repression of mucosal immune responses in mice with colon cancer following sustained administration of Streptococcus thermophiles Hadad SE, Alsolami M, Aldahlawi A, Alrahimi J, Basingab F, Hassoubah S, Alothaid H. 37



In vitro optimization, characterization and anti-tumor evaluation against colorectal cancer of a Novel 5-fluorouracil oral nanosuspension using soy protein, polysaccharides-protein complexation, and in-situ gel formation Abdullah S, El Hadad S, Aldahlawi A. 38



Spotlight on Immunity against COVID-19 with Emphasis on Cytokine Storm Aldahlawi AM, Zaher KS. 39



The Role of Immune-related NLR Pyrin Domain Containing 2 (NLRP2) Gene in the Development and Diseases Basingab F, Alghamdi A, Alhazmi S, Alrofaidi A, Alharbi M. 40



Levels and predictors of fear and health anxiety during the current outbreak of COVID-19 in immunocompromised and chronic disease patients in Saudi Arabia: A cross-sectional correlational study Al-Rahimi JS, Nass NM, Hassoubah SA, Wazqar DY, Alamoudi SA. 41



Dendritic cell-based immunotherapies and their potential use in colorectal cancer immunotherapy Aldahlawi AM, Abdullah ST. 42



An overview of the meningococcal disease and impact of the quadrivalent meningococcal conjugate vaccine Alrobai A, Alrahimi J, El Hadad S. 43



Antimicrobial Activity of Metabolites Extracted from Marine Actinomycetes Alrahimi J, Hassoubah S, Alotaibi N, Abualainin M, Albesher N, Almoubady S. 44



Impacts of saccharomyces on Cd20 and cd68 markers in diabetic Rat spleen immunized with Influenza Vaccines Aldahlawi A, Alhashmi A, Alrahimi J, Hassoubah S, EL Hadad S. 45



The development of a novel oral 5-Fluorouracil in-situ gelling nanosuspension to potentiate the anticancer activity against colorectal cancer cells Abdullah S, El Hadad S, Aldahlawi A. 46



The Glycemic Index of Food- Should It Be Gender Specific? Eldakhakhny BM, Alamoudi AA, Binmahfooz SK, Alamoudi SA, Akshawi ME, Linjawi JH. 47



Glutathione S-Transferase (GSTT1 rs17856199) and Nitric Oxide Synthase (NOS2 rs2297518) Genotype Combination as Potential Oxidative Stress-Related Molecular Markers for Type 2 Diabetes Mellitus Gusti AM, Qusti SY, Bahijri SM, Toraih EA, Bokhari S, Attallah SM, Alzahrani A, Alshehri WM, Alotaibi H, Fawzy MS. 48



Ethanol content of a traditional Saudi beverage Sobia Borai A, Sebaih S, Alshargi A, Albarzan F, Al- Ghamdi A, Al-Ghamdi S, Boraie S, Bahijri S, Al Shareef A, Al-Amri A, Ferns G. 49



Gender Differences in The Factors associated with Hypertension in Non-Diabetic Saudi Adults—A Cross-Sectional Study Al-Raddadi R, Al-Ahmadi J, Bahijri S, Ajabnoor GM, Jambi H, Enani S, Eldakhakhny BM, Alsheikh L, Borai A, Tuomilehto J. 50



The association between hypertension and other cardiovascular risk factors among nondiabetic Saudis adults-A cross sectional study Ajabnoor GM, Bahijri S, Alamoudi AA, Al Raddadi R, Al-Ahmadi J, Jambi H, Borai A, Toumilehto J. 51



BrainFD: Measuring the Intracranial Brain Volume With Fractal Dimension Ashraf GM, Chatzichronis S, Alexiou A, Kyriakopoulos N, Alghamdi BS, Tayeb HO, Alghamdi J, Khan W, Jalal B, Hazem M. 52



Empagliflozin Effectively Attenuates Olanzapine-Induced Body Weight Gain in Female Wistar Rats Ashraf GM, Alghamdi BS, Alshehri FS, Alam MZ, Tayeb HO, Tarazi FI. 53



Standardizing the Effective Correlated Dosage of Olanzapine and Empagliflozin in Female Wistar Rats Ashraf GM, Alghamdi BS, Alshehri FS, Alam MZ, Tayeb HO, Tarazi FI. 54



Tilianin Ameliorates Cognitive Dysfunction and Neuronal Damage in Rats with Vascular Dementia via p-CaMKII/ERK/CREB and ox- CaMKII-Dependent MAPK/NF- κ B Pathways Jiang H, Ashraf GM, Liu M, Zhao K, Wang Y, Wang L, Xing J, Alghamdi BS, Li Z, Liu R. 55



Implications of miR-148a-3p/p35/PTEN signaling in tau hyperphosphorylation and autoregulatory feedforward of Akt/CREB in Alzheimer’s disease Zeng L, Jiang H, Ashraf GM, Liu J, Wang L, Zhao K, Liu M, Li Z, Liu R. 56



Identification of miRNA and Their Regulatory Effects Induced by Total Flavonoids From Dracocephalum moldavica in the Treatment of Vascular Dementia Liu M, Shan G, Jiang H, Zeng L, Zhao K, Li Y, Ashraf GM, Li Z, Liu R. 57



Endothelin-1 induced global ischaemia in adult zebrafish: A model with novel entity of stroke research Chavda V, Patel S, Alghamdi BS, Ashraf GM. 58



Efonidipine Exerts Cerebroprotective Effect by Down-regulation of TGF-β/SMAD-2- Dependent Signaling Pathway in Diabetic Rats Rajput R, Chavda V, Patel SS, Barreto GE, Ashraf GM. 59



In silico interactions of statins with cell death-inducing DNA fragmentation factor-like effector A (CIDEA) Barreto GE, Gonzalez J, Reiner Ž, Jamialahmadi T, Echeverria V, Ashraf GM, Sahebkar A. 60



Physicochemical, Interaction & Topological Descriptors vs. hMAO-A Inhibition of Aplysinopsin Analogs: A Boulevard to the Discovery of Semi-synthetic Antidepression Agents Singla RK, Ashraf GM, Ganash M, Shen B. 61



Identification of new BACE1 inhibitors for treating Alzheimer’s disease Kushwaha P, Singh V, Somvanshi P, Bhardwaj T, Barreto GE, Ashraf GM, Mishra BN, Chundawat RS, Haque S. 62



MicroRNA and mRNA profiling of cerebral cortex in a transgenic mouse model of Alzheimer’s disease by RNA sequencing Zeng L, Jiang HL, Ashraf GM, Li ZR, Liu R. 63



CRISPR/Cas9 gene editing: New hope for Alzheimer’s disease therapeutics Bhardwaj S, Kesari KK, Rachamalla M, Mani S, Ashraf GM, Jha SK, Kumar P, Ambasta RK, Dureja H, Devkota HP, Gupta G. 64



Natural Products for Neurodegeneration: Regulating Neurotrophic Signals Uddin MS, Mamun AA, Rahman MM, Jeandet P, Alexiou A, Behl T, Sarwar MS, Sobarzo-Sánchez E, Ashraf GM, Sayed AA, Albadrani GM. 65



Neuroinflammatory Signaling in the Pathogenesis of Alzheimer’s Disease Uddin MS, Kabir MT, Jalouli M, Rahman MA, Jeandet P, Behl T, Alexiou A, Albadrani GM, Abdel-Daim MM, Perveen A, Ashraf GM. 66



Antioxidant and Signal-Modulating Effects of Brown Seaweed-Derived Compounds against Oxidative Stress-Associated Pathology Begum R, Howlader S, Mamun-Or-Rashid AN, Rafiquzzaman SM, Ashraf GM, Albadrani GM, Sayed AA, Peluso I, Abdel-Daim MM, Uddin M. 65



New Horizons in the Treatment of Neurological Disorders with Tailorable Gold Nanoparticles Khan M, Bilgrami AL, Rizvi A, Moshahid M. 68



The Role of Vitamins in Neurodegenerative Disease: An Update Rai SN, Singh P, Steinbusch HW, Vamanu E, Ashraf G, Singh MP. 69



Efficacy of calcitonin gene-related peptide (CGRP) receptor blockers in reducing the number of monthly migraine headache days (MHDs): A network meta-analysis of randomized controlled trials Masoud AT, Hasan MT, Sayed A, Edward HN, Amer AM, Naga AE, Elfil M, Alghamdi BS, Perveen A, Ashraf GM, Bahbah EI. 70



Peptide Based Therapy for Neurological Disorders Yadav A, Pandey D, Ashraf GM. 71



Delineation of Neuroprotective Effects and Possible Benefits of AntioxidantsTherapy for the Treatment of Alzheimer’s Diseases by Targeting Mitochondrial-Derived Reactive Oxygen Species: Bench to Bedside Walia V, Kaushik D, Mittal V, Kumar K, Verma R, Parashar J, Akter R, Rahman M, Bhatia S, Al- Harrasi A, Karthika C. 72



Promising Strategies of Colloidal Drug Delivery-Based Approaches in Psoriasis Management Singh S, Sharma N, Behl T, Sarkar BC, Saha HR, Garg K, Singh SK, Arora S, Amran M, Abdellatif AA, Bilgrami AL. 73



Mechanistic insights into the role of serum-glucocorticoid kinase 1 in diabetic nephropathy: A systematic review Noor S, Mohammad T, Ashraf GM, Farhat J, Bilgrami AL, Eapen MS, Sohal SS, Yadav DK, Hassan MI. 74



Deciphering the Interacting Mechanisms of Circadian Disruption and Alzheimer’s Disease Uddin MS, Sumsuzzman DM, Jeandet P, Behl T, Rauf A, Amran MS, Ashraf GM. 75



Exploring the Role of Monoamine Oxidase Activity in Aging and Alzheimer’s Disease Rahman M, Uddin M, Samsuzzaman M, Behl T, Hafeez A, Perveen A, Barreto GE. 76



Recent Advances in Synaptosomal Proteomics in Alzheimer’s Disease Ahmad F, Haque S, Chavda V, Ashraf GM. 77



Impaired Quality Control of Mitochondria Underlying the Pathogenesis of Alzheimer’s Disease Uddin MS, Katha UT, Ashraf GM. 78



Epigenetics of glioblastoma multiforme: From molecular mechanisms to therapeutic approaches Uddin MS, Al Mamun A, Alghamdi BS, Tewari D, Jeandet P, Sarwar MS, Ashraf GM. 79



Exploring the Anti-Neuroinflammatory Potential of Steroid and Terpenoid-Derived Phytochemicals to Combat Alzheimer’s Disease Kabir M, Uddin M, Zaman S, Rahman M, Behl T, Ahmad A, Hafeez A, Perveen A, Ashraf GM. 80



Suicide and Suicide Attempts in Elderly Patients: An Epidemiological Analysis of Risk Factors and Prevention Makara-Studzińska M, Somasundaram SG, Halicka J, Madej A, Leszek J, Rehan M, Ashraf GM, Gavryushova LV, Nikolenko VN, Mikhaleva LM, Muresanu C. 81



Deciphering the Role of Nanoparticle-based Treatment for Parkinson’s Disease Moni M, Rahman M, Begum M, Uddin M, Ashraf GM. 82



Synaptotagmin-1: A Multi-Functional Protein that Mediates Vesicle Docking, Priming, and Fusion Ullah N, Maaiden EE, Uddin M, Ashraf GM. 83



Neurotoxic Aβ:Linking Extracellular and Intracellular Aβ in Alzheimer’s Disease Uddin MS, Al Mamun A, Ashraf GM. 84



Exploring the Role of CLU in the Pathogenesis of Alzheimer’s Disease Uddin M, Kabir M, Begum M, Islam M, Behl T, Ashraf GM. 85



Nano-Neurotherapeutics (NNTs): An Emergent and Multifaceted Tool for CNS Disorders Sharma A, Manchanda R, Pottoo FH, Ashraf GM. 86



Challenges of Gene Therapy for Neurodegenerative Disorders Uddin MS, Khan ZA, Sumsuzzman DM, Perveen A, Ashraf GM, Puranik N, Yadav D, Chauhan PS, Kwak M, Jin JO. 87



Neural Stem Cell-Based Therapies and Glioblastoma Management: Current Evidence and Clinical Challenges Benmelouka AY, Munir M, Sayed A, Attia MS, Ali MM, Negida A, Alghamdi BS, Kamal MA, Barreto GE, Ashraf GM, Meshref M. 88



Sleep Disturbances and Cognitive Impairment in the Course of Type 2 Diabetes-A Possible link Brzecka A, Madetko N, Nikolenko VN, Ashraf GM, Ejma M, Leszek J, Daroszewski C, Sarul K, Mikhaleva LM, Somasundaram SG, Kirkland CE. 89



Anti-Neuroinflammatory Potential of Polyphenols by Inhibiting NF-κB to Halt Alzheimer’s Disease Uddin MS, Hasana S, Ahmad J, Hossain M, Rahman M, Behl T, Rauf A, Ahmad A, Hafeez A, Perveen A, Ashraf GM. 90



Exploring Potential of Alkaloidal Phytochemicals Targeting Neuroinflammatory Signaling of Alzheimer’s Diseas Uddin MS, Kabir M, Al Mamun A, Behl T, Mansouri RA, Aloqbi AA, Perveen A, Hafeez A, Ashraf GM. 91



Molecular Mechanisms of Metal Toxicity in the Pathogenesis of Alzheimer’s Disease Kabir MT, Uddin MS, Zaman S, Begum Y, Ashraf GM, Bin-Jumah MN, Bungau SG, Mousa SA, Abdel-Daim MM. 92



Molecular Genetics of Early- and Late- Onset Alzheimer’s Diseas Uddin MS, Hasana S, Hossain M, Islam M, Behl T, Perveen A, Hafeez A, Ashraf GM. 93



Exploring the New Horizon of AdipoQ in Obesity-Related Alzheimer’s Dementia Uddin M, Rahman M, Sufian MA, Jeandet P, Ashraf GM, Bin-Jumah MN, Mousa SA, Abdel- Daim MM, Akhtar MF, Saleem A, Amran M. 94



Multi-Target Drug Candidates for Multifactorial Alzheimer’s Disease: AChE and NMDAR as Molecular Targets,Uddin MS, Al Mamun A, Kabir MT, Ashraf GM, Bin-Jumah MN, Abdel-Daim MM. 95



Melatonin attenuates morphine-induced conditioned place preference in Wistar rats Alshehri FS, Alghamdi BS, Hakami AY, Alshehri AA, Althobaiti YS. 96



Depression, anxiety and stress in Saudi migraine patients using DASS-21: local population-based cross-sectional survey Al-Hayani M, AboTaleb H, Bazi A, Alghamdi B. 97



Effects of melatonin and resveratrol on recognition memory and passive avoidance performance in a mouse model of Alzheimer’s disease, Labban S, Alghamdi BS, Alshehri FS, Kurdi M. 98



Migraine-Related Disabilities Among Saudi Migraine Patients and Its Association with Social Factors AboTaleb HA, Al-Hayani MM, Alghamdi BS. 99



Melatonin Blocks Morphine-Induced Place Preference: Involvement of GLT-1, NF-κB, BDNF, and CREB in the Nucleus Accumbens Alghamdi BS, Alshehri FS. 100



Melatonin Improves Short-Term Spatial Memory in a Mouse Model of Alzheimer’s Disease Labban S, Alshehri FS, Kurdi M, Alatawi Y, Alghamdi BS. 101



Relationship Between Public Mental Health and Immune Status During the COVID-19 Pandemic: Cross-Sectional Data from Saudi Arabia Alghamdi BS, Alatawi Y, Alshehri FS, Tayeb HO, Tarazi FI. 102



Globular glial tauopathy, a newly recognized white matter tauopathy, with depression/anxiety disorder: report and review of classification Kurdi M, Alghamdi BS, Parfitt J, Ang LC. 103



Psychological Distress During COVID-19 Curfews and Social Distancing in Saudi Arabia: A Cross-Sectional Study Alghamdi BS, AlAtawi Y, AlShehri FS, Tayeb HO, Taleb HA, Binsalman A. 104



Molecular Characterization of Integrons and Their Association with Antibiotic Resistance in Acinetobacter baumannii Isolated from Hospitals in Jeddah Alam MZ. 105



Conditionally Reprogrammed Cells and Robotic High-Throughput Screening for Precision Cancer Therapy Alkhilaiwi F. 106



Why do cancer cells break from host circadian rhythm? Insights from unicellular organisms Alamoudi AA. 107



Colossolactone-G synergizes the anticancer properties of 5-fluorouracil and gemcitabine against colorectal cancer cells Algehani RA, Abou Khouzam R, Hegazy GA, Alamoudi AA, El-Halawany AM, El Dine RS, Ajabnoor GA, Al-Abbasi FA, Baghdadi MA, Elsayed I, Hattori M. 108



MSCs and their exosomes: a rapidly evolving approach in the context of cutaneous wounds therapy Marofi F, Alexandrovna KI, Margiana R, Bahramali M, Suksatan W, Abdelbasset WK, Chupradit S, Nasimi M, Maashi MS. 109



Cloning and Embryo Splitting in Mammalians: Brief History, Methods, and Achievements Rahbaran M, Razeghian E, Maashi MS, Jalil AT, Widjaja G, Thangavelu L, Kuznetsova MY, Nasirmoghadas P, Heidari F, Marofi F, Jarahian M. 110



Re-Expression of Poly/Oligo-Sialylated Adhesion Molecules on the Surface of Tumor Cells Disrupts Their Interaction with Immune-Effector Cells and Contributes to Pathophysiological Immune Escape Jarahian M, Marofi F, Maashi MS, Ghaebi M, Khezri A, Berger MR. 111



Formulating etoposide in a nanoemulsion containing polyunsaturated fatty acids potentiates its anti-proliferation and antiinvasion activities against the ovarian cancer cells Alkhatib MH, Al-Hashemi SM, Gashlan HM. 112



Ethyl glucuronide and ethyl sulfate: a review of their roles in forensic toxicology analysis of alcohol postmortem Alsayed SN, Alharbi AG, Alhejaili AS, Aljukhlub RJ, Al-Amoudi DH, Ashankyty AI, Alzahrani MA, Zughaibi TA, Alharbi OA, Kheyami AM, Helmi NM. 113



A Computational Approach Identified Andrographolide as a Potential Drug for Suppressing COVID-19-Induced Cytokine Storm Rehan M, Ahmed F, Howladar SM, Refai MY, Baeissa HM, Zughaibi TA, Kedwa KM, Jamal MS. 114



Forensic Analysis of Polymeric Carpet Fibers Using Direct Analysis in Real Time Coupled to an AccuTOF™ Mass Spectrometer Zughaibi TA, Steiner RR. 115



Substance Use Disorder and COVID-19; Forensic Medicine and Pharmacology Perspectives: A Concise Narrative Review Ali A, Al-Zughaibi T, Shaker AA. 116



Fusaripyridines A and B; Highly Oxygenated Antimicrobial Alkaloid Dimers Featuring an Unprecedented 1,4-Bis(2- hydroxy-1,2-dihydropyridin-2-yl)butane-2,3- dione Core from the Marine Fungus Fusarium sp. LY019 Shaala LA, Alzughaibi T, Genta-Jouve G, Youssef DT. 117



Concatenation of molecular docking and molecular simulation of BACE-1, γ-secretase targeted ligands: in pursuit of Alzheimer’s treatment Jabir NR, Rehman MT, Alsolami K, Shakil S, Zughaibi TA, Alserihi RF, Khan MS, AlAjmi MF, Tabrez S. 118



Polyphenols as anticancer agents: Toxicological concern to healthy cells Islam BU, Suhail M, Khan MK, Zughaibi TA, Alserihi RF, Zaidi SK, Tabrez S. 119



Targeting PI3K/Akt/mTOR Pathway by Different Flavonoids: A Cancer Chemopreventive Approach Zughaibi TA, Suhail M, Tarique M, Tabrez S. 120



Flavonoids and PI3K/Akt/mTOR Signaling Cascade: A Potential Crosstalk in Anticancer Treatment,ul Islam B, Suhail M, Khan MS, Ahmad A, Zughaibi TA, Husain FM, Rehman MT, Tabrez S. 121



Genotyping of interleukins-18 promoters and their correlation with coronary artery stenosis in Saudi population Tabrez S, Jabir NR, Zughaibi TA, Shakil S. 122



Identification of Butyrylcholinesterase and Monoamine Oxidase B Targeted Ligands and their Putative Application in Alzheimer’s Treatment: A Computational Strategy Jabir NR, Rehman M, Tabrez S, Alserihi RF, AlAjmi MF, Khan MS, Husain FM, Ahmed BA. 123



Identification of novel cardiovascular disease associated metabolites using untargeted metabolomics Tabrez S, Mohammed MR, Jabir NR, Khan MI. 124



Anticancer Potential of Biogenic Silver Nanoparticles: A Mechanistic Study Khan MS, Alomari A, Tabrez S, Hassan I, Wahab R, Bhat SA, Alafaleq NO, Altwaijry N, Shaik GM, Zaidi SK, Nouh W. 125



Bioaccumulation of heavy metals and their toxicity assessment in Mystus species Tabrez S, Zughaibi TA, Javed M. 126



Dissecting Sex-Related Cognition between Alzheimer’s Disease and Diabetes: From Molecular Mechanisms to Potential Therapeutic Strategies Ashraf GM, Ebada MA, Suhail M, Ali A, Uddin M, Bilgrami AL, Perveen A, Husain A, Tarique M, Hafeez A, Alexiou A. 127



Nationwide Seroprevalence of SARSCoV- 2 in Saudi Arabia ,Alharbi NK, Alghnam S, Algaissi A, Albalawi H, Alenazi MW, Albargawi AM, Alharbi AG, Alhazmi A, Al Qarni A, Alfarhan A, Zowawi HM. 128



A Robust, Safe, and Scalable Magnetic Nanoparticle Workflow for RNA Extraction of Pathogens from Clinical and Wastewater Samples Ramos‐Mandujano G, Salunke R, Mfarrej S, Rachmadi AT, Hala S, Xu J, Alofi FS, Khogeer A, Hashem AM, Almontashiri NA, Alsomali A. 129



Simultaneous detection and mutation surveillance of SARS-CoV-2 and multiple respiratory viruses by rapid field-deployable sequencing Bi C, Ramos-Mandujano G, Tian Y, Hala S, Xu J, Mfarrej S, Esteban CR, Delicado EN, Alofi FS, Khogeer A, Hashem AM. 130



Quick and Easy Assembly of a One-Step qRT-PCR Kit for COVID-19 Diagnostics Using In-House Enzymes Takahashi M, Tehseen M, Salunke R, Takahashi E, Mfarrej S, Sobhy MA, Alhamlan FS, Hala S, Ramos-Mandujano G, Al-Qahtani AA, Alofi FS. 131



Seroprevalence of SARS-CoV-2 (COVID-19) among healthcare workers in Saudi Arabia: comparing case and control hospitals Alserehi HA, Alqunaibet AM, Al-Tawfiq JA, Alharbi NK, Alshukairi AN, Alanazi KH, Saleh GM, Alshehri AM, Almasoud A, Hashem AM, Alruwaily AR. 132



Cellular and Humoral Immunogenicity of a Candidate DNA Vaccine Expressing SARSCoV- 2 Spike Subunit 1 Alluhaybi KA, Alharbi RH, Alhabbab RY, Aljehani ND, Alamri SS, Basabrain M, Alharbi R, Abdulaal WH, Alfaleh MA, Tamming L, Zhang W. 133



Seroprevalence of SARS-CoV-2 Binding and Neutralizing Antibodies in Healthcare Workers during the Epidemic Peak in Referral Hospitals and Quarantine Sites: Saudi Arabia Alhabbab RY, Alsaieedi A, Algaissi A, Almahboub S, Al-Raddadi RM, Shabouni OI, Alhabbab R, Alfaraj AA, Alamri SS, Aljehani ND, Abdulal RH. 134



Synthetic SARS-CoV-2 Spike-Based DNA Vaccine Elicits Robust and Long-Lasting Th1 Humoral and Cellular Immunity in Mice Alamri SS, Alluhaybi KA, Alhabbab RY, Basabrain M, Algaissi A, Almahboub S, Alfaleh MA, Abujamel TS, Abdulaal WH, ElAssouli M, Alharbi RH. 135



Iron Chelation Reduces DNA Damage in Sickle Cell Anemia ,Al-Khateeb RS, Althagafy HS, ElAssouli MZ, Nori DA, AlFattani M, Al-Najjar SA, Al Amri T, Hashem AM, Harakeh S, Helmi N. 136



Targeted Inhibition of Fibroblast Growth Factor Receptor 1-GLI Through AZD4547 and GANT61 Modulates Breast Cancer Progression Riaz SK, Khan W, Wang F, Khaliq T, Malik A, Razia ET, Khan JS, Haque S, Hashem AM, Alkhayyat SS, Azhar NE. 137



Side Effects of COVID-19 Pfizer-BioNTech mRNA Vaccine in Children Aged 12–18 Years in Saudi Arabia Alamer E, Alhazmi A, Qasir NA, Alamer R, Areeshi H, Gohal G, Qadri M, Hashem AM, Algaissi A. 138



Community-Based Seroprevalence of SARS-CoV-2 Antibodies following the First Wave of the COVID-19 Pandemic in Jazan Province, Saudi Arabia Alhazmi A, Alamer E, Abdelwahab S, Khamjan N, Hamami A, Haddad M, Darraj M, Hashem AM, Algaissi A. 139



Synthetic vaccine affords full protection to mice against lethal challenge of influenza B virus of both genetic lineages Gravel C, Muralidharan A, Duran A, Zetner A, Pfeifle A, Zhang W, Hashem A, Tamming L,Farnsworth A, Loemba H, Chen W. 140



Profile of Circulatory Cytokines and Chemokines in Human Coronaviruses: A Systematic Review and Meta-Analysis Zawawi A, Naser AY, Alwafi H, Minshawi F. 141



Fecal Transplant and Bifidobacterium Treatments Modulate Gut Clostridium Bacteria and Rescue Social Impairment and Hippocampal BDNF Expression in a Rodent Model of Autism Abuaish S, Al-Otaibi NM, Abujamel TS, Alzahrani SA, Alotaibi SM, AlShawakir YA, Aabed K, El- Ansary A. 142



The role of sex-differentiated variations in stress hormones, antioxidants, and neuroimmune responses in relation to social interaction impairment in a rodent model of autism Abuaish S, Al-Otaibi NM, Aabed K, Abujamel TS, Alzahrani SA, Alotaibi SM, Bhat RS, Arzoo S, El- Ansary A. 143



Optimizing the catalytic activities of methanol and thermotolerant Kocuria flava lipases for biodiesel production from cooking oil wastes Najjar A, Hassan EA, Zabermawi N, Saber SH, Bajrai LH, Almuhayawi MS, Abujamel TS, Almasaudi SB, Azhar LE, Moulay M, Harakeh S. 144



Enhancement of β-Glucan Biological Activity Using a Modified Acid-Base Extraction Method from Saccharomyces cerevisiae Mahmoud Amer E, Saber SH, Abo Markeb A, Elkhawaga AA, Mekhemer I, Zohri AN, Abujamel TS, Harakeh S, Abd-Allah EA. 145



Phytochemical-Based Nano- Pharmacotherapeutics for Management of Burn Wound Healing Qadir A, Jahan S, Aqil M, Warsi MH, Alhakamy NA, Alfaleh MA, Khan N, Ali A. 146



Mechanisms Involved in Microglial- Interceded Alzheimer’s Disease and Nanocarrier-Based Treatment Approaches Md S, Alhakamy NA, Alfaleh MA, Afzal O, Altamimi AS, Iqubal A, Shaik RA. 147



Impact of Protein Corona on the Biological Identity of Nanomedicine: Understanding the Fate of Nanomaterials in the Biological Milieu Akhter MH, Khalilullah H, Gupta M, Alfaleh MA, Alhakamy NA, Riadi Y, Md S. 148



Recent Developments in Diagnosis of Epilepsy: Scope of MicroRNA and Technological Advancements Bandopadhyay R, Singh T, Ghoneim MM, Alshehri S, Angelopoulou E, Paudel YN, Piperi C, Ahmad J, Alhakamy NA, Alfaleh MA, Mishra A. 149



Plumbagin-Loaded Glycerosome Gel as Topical Delivery System for Skin Cancer Therapy Md S, Alhakamy NA, Aldawsari HM, Husain M, Khan N, Alfaleh MA, Asfour HZ, Riadi Y, Bilgrami AL, Akhter MH. 150



Development of an Icariin-Loaded Bilosome-Melittin Formulation with Improved Anticancer Activity against Cancerous Pancreatic Cells Alhakamy NA, Badr-Eldin SM, Alharbi WS, Alfaleh MA, Al-Hejaili OD, Aldawsari HM, Eid BG, Bakhaidar R, Drago F, Caraci F, Caruso G. 151



‘Silymarin’ a Potential Treatment Targeting Hepatic Fibrosis of Schistosomiasis Alghanmi M, Alrafiah A. 152



Endolysosome iron restricts Tat-mediated HIV-1 LTR transactivation by increasing HIV- 1 Tat oligomerization and β-catenin expression Khan N, Halcrow PW, Lakpa LK, Rehan M, Chen X, Geiger JD. 153



Computational Insights into the Interaction between Cytoadherence Receptor gC1qR and the DBLβ12 Domain of a Plasmodium falciparum PfEMP1 Ligand Bakri R, Rehan M, Shamshad H, Hafiz A. 154



A Novel Homozygous Missense Mutation in the Zinc Finger DNA Binding Domain of GLI1 Causes Recessive Post-Axial Polydactyly Umair M, Ahmad F, Ahmad S, Alam Q, Rehan M, Alqosaibi AI, Alnamshan MM, Rafeeq MM, Haque S, Sain ZM, Ismail M. 155



Synthesis, Characterization, Molecular Docking and Antimicrobial Activity of Novel Spiropyrrolidine Derivatives Asad M, Arshad MN, Asiri AM, Khan SA, Rehan M, Oves M. 156



Design and synthesis of novel pyrazoline derivatives for their spectroscopic, single crystal X-ray and biological studies Asad M, Khan SA, Arshad MN, Asiri AM, Rehan M. 157



Discovery of a novel and a rare Kristen rat sarcoma viral oncogene homolog (KRAS) gene mutation in colorectal cancer patients Rasool M, Carracedo A, Sibiany A, Al-Sayes F, Karim S, Haque A, Natesan Pushparaj P, Asif M, Achakzai NM. 158



Assessment of clinical variables as predictive markers in the development and progression of colorectal cancer Rasool M, Malik A, Waquar S, Ain QT, Rasool R, Asif M, Anfinan N, Haque A, Alam H, Ahmed S, Hamid Hamdard M. 159



Magnificines A and B, Antimicrobial Marine Alkaloids Featuring a Tetrahydrooxazolo[3,2-a]azepine-2,5(3H,6H)- dione Backbone from the Red Sea Sponge Negombata magnifica Youssef DT, Asfour HZ, Genta-Jouve G, Shaala LA. 160



Psammaceratin A: A Cytotoxic Psammaplysin Dimer Featuring an Unprecedented (2Z,3Z)-2,3- Bis(aminomethylene)succinamide Backbone from the Red Sea Sponge Pseudoceratina arabica Youssef DT, Asfour HZ, Shaala LA. 161



Hemimycalins C–E; Cytotoxic and Antimicrobial Alkaloids with Hydantoin and 2-Iminoimidazolidin-4-one Backbones from the Red Sea Marine Sponge Hemimycale sp. Shaala LA, Youssef DT, 162



The efficacy of interactive group psychoeducation for children with leukaemia: A randomised controlled trial Day M, Harris S, Hussein D, Saka MY, Stride C, Jones M, Makin G, Rowe R. 163



Editorial: Advances in Cancer Stem Cell Biology Hussein D, Pires IM, Krause P, Schulten HJ. 164



The impact of blood donation on blood counts and ferritin levels: A multi-center study from the Eastern Mediterranean region, Hindawi S, Badawi M, Hussein D, Al-Riyami AZ, Daghman NA, Rafie NI, Belgasm NM, Al Zaabi E, Oumeziane N. 165



Structural Aspects of Potential Endocrine- Disrupting Activity of Stereoisomers for a Common Pesticide Permethrin against Androgen Receptor Sheikh IA, Beg MA. 166



Structural binding perspectives of common plasticizers and a flame retardant BDE-153 against thyroxine binding globulin: potential for endocrine disruption Sheikh IA, Beg MA. 167



Hemodynamic, endocrine, and gene expression mechanisms regulating equine ovarian follicular and cellular development Wischral A, Pastorello M, Gastal MO, Beg MA, Gastal EL. 168



Two Novel Homozygous HPS6 Mutations (Double Mutant) Identified by Whole-Exome Sequencing in a Saudi Consanguineous Family Suspected for Oculocutaneous Albinism Karim S, Saharti S, Alganmi N, Mirza Z, Alfares A, Turkistany S, Al-Attas M, Noureldin H, Al Sakkaf K, Abusamra H, Al-Qahtani M. 169



Development of “Biosearch System” for biobank management and storage of disease associated genetic information Karim S, Al-Kharraz M, Mirza Z, Noureldin H, Abusamara H, Alganmi N, Merdad A, Jastaniah S, Kumar S, Rasool M, Abuzenadah A. 170



Integrated Genomic Analysis Identifies ANKRD36 Gene as a Novel and Common Biomarker of Disease Progression in Chronic Myeloid Leukemia Iqbal Z, Absar M, Akhtar T, Aleem A, Jameel A, Basit S, Ullah A, Afzal S, Ramzan K, Rasool M,Karim S. 171



In Vitro Inhibitory Analysis of Rationally Designed siRNAs against MERS-CoV Replication in Huh7 Cells,El-Kafrawy SA, Sohrab SS, Mirza Z, Hassan AM, Alsaqaf F, Azhar EI. 172



Nanoparticles-based drug delivery and gene therapy for breast cancer: Recent advancements and future challenges Mirza Z, Karim S. 173



In silico prediction and experimental validation of siRNAs targeting ORF1ab of MERS-CoV in Vero cell line Sohrab SS, El-Kafrawy SA, Mirza Z, Hassan AM, Alsaqaf F, Azhar EI. 174



Designing and evaluation of MERS-CoV siRNAs in HEK-293 cell line Sohrab SS, El-Kafrawy SA, Mirza Z, Hassan AM, Alsaqaf F, Azhar EI. 175



Thymoquinone nanoparticles protect against cisplatin-induced nephrotoxicity in Ehrlich carcinoma model without compromising cisplatin anti-cancer efficacy Harkaeh S, Qari Y, Tashkandi H, Almuhayawi M, Saber SH, El-Shitany N, Shaker S, Lucas F, Alamri T, Al-Jaouni S, Mousa S. 176



Isolation and Identification of a Wastewater Siphoviridae Bacteriophage Targeting Multidrug-resistant Klebsiella pneumoniae Qadri I, Harakeh S, Teklemariam AD, Al Amri T, Al-Hindi R. 177



Suspected reinfections of SARS-COV-2 in Khyber Pakhtunkhwa, Pakistan – analysis of province-wide testing database Ahmad HA, Khan H, Shahzad M, ul Haq Z, Harakeh S, Yousafzai YM. 178



Analysis of RAS gene mutations in cytogenetically normal de novo acute myeloid leukemia patients reveals some novel alterations Akram AM, Chaudhary A, Kausar H, Althobaiti F, Abbas AS, Hussain Z, Fatima N, Zafar E, Asif W, Afzal U, Yousaf Z. 179



Corrigendum to “In vitro antibacterial activity of honey against multidrug-resistant Shigella sonnei” [Compl. Ther. Clin. Pract. 41 (2020) 1–8/101257] Al-Masaudi SB, Hussain MB, Al-Maaqar SM, Al Jaouni S, Harakeh S. 180



Minor to Moderate Side Effects of Pfizer-BioNTech COVID-19 Vaccine Among Saudi Residents: A Retrospective Cross-Sectional Study, El-Shitany NA, Harakeh S, Badr-Eldin SM, Bagher AM, Eid B, Almukadi H, Alghamdi BS, Alahmadi AA, Hassan NA, Sindi N, Alghamdi SA. 181



The Impact of ABO Blood Grouping on COVID-19 Vulnerability and Seriousness: A Retrospective Cross-Sectional Controlled Study among the Arab Community El-Shitany NA, El-Hamamsy M, Alahmadi AA, Eid BG, Neamatallah T, Almukadi HS, Arab RA, Faddladdeen KA, Al-Sulami KA, Bahshwan SM, Ali SS. 182



Reverse transcriptase loop-mediated isothermal amplification (RT-LAMP)- based diagnosis: A potential alternative to quantitative real-time PCR based detection of the novel SARS-COV-2 virus Haq F, Sharif S, Khurshid A, Ikram A, Shabbir I, Salman M, Ahad A, Rana MS, Raja A, Badar N, Tashkandi H. 183



A Novel Nanoformulation of Ellagic Acid is Promising in Restoring Oxidative Homeostasis in Rat Brains with Alzheimer’s Disease, Harakeh S, Qari MH, Ramadan WS, Al Jaouni SK, Almuhayawi MS, Al Amri T, Ashraf GM, Bharali DJ, Mousa SA. 184



Therapeutic and pharmacological potential of Tanshinones against lung cancer: A systematic review, Alam SS, Uddin F, Khan FB, Kamal MA, Hoque M. 185



Can manipulation of gut microbiota really be transformed into an intervention strategy for cardiovascular disease management? Mehmood K, Moin A, Hussain T, Rizvi SM, Gowda DV, Shakil S, Kamal MA. 186



Natural products: Potential targets of TME related long non-coding RNAs in lung cancer Malla RR, Padmaraju V, Marni R, Kamal MA. 187



Analysis of post COVID-19 condition and its overlap with myalgic encephalomyelitis/ chronic fatigue syndrome Sukocheva OA, Maksoud R, Beeraka NM, Madhunapantula SV, Sinelnikov M, Nikolenko VN, Neganova ME, Klochkov SG, Kamal MA, Staines DR, Marshall-Gradisnik S. 188



Diallyl disulfide and diallyl trisulfide in garlic as novel therapeutic agents to overcome drug resistance in breast cancer Malla R, Marni R, Chakraborty A, Kamal MA. 189



Corrigendum to “Honokiol: A review of its pharmacological potential and therapeutic insights” [Phytomedicine, 153647] Rauf A, Olatunde A, Imran M, Alhumaydhi FA, Aljohani AS, Khan SA, Uddin MS, Mitra S, Emran TB, Khayrullin M, Rebezov M. 190



Natural Product-Based Studies for the Management of Castration-Resistant Prostate Cancer: Computational to Clinical Studies Singla RK, Sharma P, Dubey AK, Gundamaraju R, Kumar D, Kumar S, Madaan R, Shri R, Tsagkaris C, Parisi S, Joon S. 191



Alzheimer Disease and Sleep Disorders: Insights into the Possible Disease Connections and the Potential Therapeutic Targets (Part I) Bahbah EI, Kamal MA. 192



Study of Nutraceuticals and Phytochemicals for the Management of Alzheimer’s Disease: A Review Ahmad SS, Khalid M, Kamal MA, Younis K. 193



Prospective Function of Different Antioxidant Containing Natural Products in the Treatment of Neurodegenerative Diseases Rahman MH, Akter R, Kamal MA. 194



Inflammation and Alzheimer’s Disease: Mechanisms and Therapeutic Implications by Natural Products Rather MA, Khan A, Alshahrani S, Rashid H, Qadri M, Rashid S, Alsaffar RM, Kamal MA, Rehman MU. 195



Honokiol: A review of its pharmacological potential and therapeutic insights Rauf A, Olatunde A, Imran M, Alhumaydhi FA, Aljohani AS, Khan SA, Uddin MS, Mitra S, Emran TB, Khayrullin M, Rebezov M. 196



Molecular docking of alpha-enolase to elucidate the promising candidates against Streptococcus pneumoniae infection Hassan M, Baig AA, Attique SA, Abbas S, Khan F, Zahid S, Ain QU, Usman M, Simbak NB, Kamal MA, Yusof HA. 197



Multi-Omics Approach in the Identification of Potential Therapeutic Biomolecule for COVID-19 Singh R, Singh PK, Kumar R, Kabir M, Kamal MA, Rauf A, Albadrani GM, Sayed AA, Mousa SA, Abdel-Daim MM, Uddin M. 198



Micro-RNAs in the regulation of immune response against SARS CoV-2 and other viral infections Abu-Izneid T, AlHajri N, Ibrahim AM, Javed MN, Salem KM, Pottoo FH, Kamal MA. 199



Prevalence and characteristics of fever in adult and paediatric patients with coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis of 17515 patients Islam MA, Kundu S, Alam SS, Hossan T, Kamal MA, Hassan R. 200



Targeting COVID-19 in Parkinson’s Patients: Drugs Repurposed Anwar F, Naqvi S, Al-Abbasi FA, Neelofar N, Kumar V, Sahoo A, Kamal MA. 201



Prevention Knowledge and Its Practice Towards COVID-19 Among General Population of Saudi Arabia: A Gender-based Perspective Alshammary F, Siddiqui AA, Amin J, Ilyas M, Rathore HA, Hassan I, Alam MK, Kamal MA. 202



Molecular Docking Studies Reveal Rhein from rhubarb ( Rheum rhabarbarum) as a Putative Inhibitor of ATP-binding Cassette Super-family G member 2 Khan MS, Mehmood B, Yousafi Q, Bibi S, Fazal S, Saleem S, Sajid MW, Ihsan A, Azhar M, Kamal MA. 203



Special issue: Cancer nanotherapeutics: Targeted medicine, therapeutic vaccination and challenges with cancer nanomedicines Rahman M, Kamal MA. 204



Drug designing against NSP15 of SARSCOV2 via high throughput computational screening and structural dynamics approach Batool A, Bibi N, Amin F, Kamal MA. 205



A cross-talk between gut microbiome, salt and hypertension Naqvi S, Asar TO, Kumar V, Al-Abbasi FA, Alhayyani S, Kamal MA, Anwar F. 206



Particulate β-glucan activates early and delayed phagosomal maturation and autophagy within macrophage in a NOX-2 dependent manner Fatima N, Upadhyay T, Ahmad F, Arshad M, Kamal MA, Sharma D, Sharma R. 207



Prospects for Discovering the Secondary Metabolites of Cordyceps Sensu Lato by the Integrated Strategy Bibi S, Wang YB, Tang DX, Kamal MA, Yu H. 208



Nanoparticles guided drug delivery and imaging in gastric cancer Nagaraju GP, Srivani G, Dariya B, Chalikonda G, Farran B, Behera SK, Alam A, Kamal MA. 209



Nanomedicine in treatment of breast cancer – A challenge to conventional therapy Afzal M, Alharbi KS, Alruwaili NK, Al-Abassi FA, Al-Malki AA, Kazmi I, Kumar V, Kamal MA,Nadeem MS, Aslam M, Anwar F. 210



Specific targeting cancer cells with nanoparticles and drug delivery in cancer therapy Raj S, Khurana S, Choudhari R, Kesari KK, Kamal MA, Garg N, Ruokolainen J, Das BC, Kumar D. 211



Nanotechnological based miRNA intervention in the therapeutic management of neuroblastoma Pottoo FH, Barkat MA, Ansari MA, Javed MN, Jamal QM, Kamal MA. 212



Dietary flavonoids: Nano delivery and nanoparticles for cancer therapy Aiello P, Consalvi S, Poce G, Raguzzini A, Toti E, Palmery M, Biava M, Bernardi M, Kamal MA, Perry G, Peluso I. 213



Flavonoids nanoparticles in cancer: Treatment, prevention and clinical prospects Khan H, Ullah H, Martorell M, Valdes SE, Belwal T, Tejada S, Sureda A, Kamal MA. 214



Horizons of nanotechnology applications in female specific cancers Rajitha B, Malla RR, Vadde R, Kasa P, Prasad GL, Farran B, Kumari S, Pavitra E, Kamal MA,Raju GS, Peela S. 215



Engineered nanoparticles for imaging and drug delivery in colorectal cancer Pavitra E, Dariya B, Srivani G, Kang SM, Alam A, Sudhir PR, Kamal MA, Raju GS, Han YK, Lakkakula BV, Nagaraju GP. 216



Natural Products for the Prevention and Control of the COVID-19 Pandemic: Sustainable Bioresources Singla RK, He X, Chopra H, Tsagkaris C, Shen L, Kamal MA, Shen B. 217



LPS/TLR4 pathways in breast cancer: insights into cell signalling Afroz R, Tanvir EM, Tania M, Fu J, Kamal MA, Khan M. 218



Endometrial Cancer: Genetic, Metabolic Characteristics, Therapeutic Strategies and Nanomedicine Cai Y, Wang B, Xu W, Liu K, Gao Y, Guo C, Chen J, Kamal MA, Yuan C. 219



Health Science Community Will Miss This Bright and Uniting Star: In Memory of Professor Gjumrakch Aliev, M.D, Ph.D. Chubarev VN, Beeraka NM, Sinelnikov MY, Bulygin KV, Nikolenko VN, Mihaylenko E, Tarasov VV, Mikhaleva LM, Poltronieri P, Viswanadha VP, Somasundaram SG. 220



Sleep Disorders Research From 1945 to 2020: A Bibliometric Analysis Hassan W, Zafar M, Noreen H, Ara A, Duarte AE, Kamdem JP, Kamal MA, Teixeira da Rocha JB. 221



Cellular and Molecular Mechanisms of Dementia: Decoding the Causal of Diabetes Mellitus in Alzheimer’s Disease Rasool M, Malik A, Waquar S, Zaheer A, Asif M, Iqbal Z, Gauthaman K, Kamal MA. 222



Emerging Therapeutic Approaches to COVID-19 Singh IK, Kumari P, Mittal P, Kumar A, Singal B, Hasan GM, Aggarwal R, Kamal MA, Singh A, Hassan M. 223



Functional Neuroproteomics: An Imperative Approach for Unravelling Protein Implicated Complexities of Brain Husain I, Ahmad W, Ali A, Anwar L, Nuruddin SM, Ashraf K, Kamal MA. 224



Exosomes: Critical Mediators of Tumour Microenvironment Reprogramming. Malla RR, Shailender G, Kamal MA. 225



Emergence and Re-emergence of Human Coronaviruses: Spike Protein as the Potential Molecular Switch and Pharmaceutical Target. Ahmad F, Kamal MA, Tekwani BL. 226



ROS-Responsive Nanomedicine: Towards Targeting the Breast Tumor Microenvironment Malla R, Kamal MA. 227



Coronavirus Disease -2019 (COVID-19) in 2020: A Perspective Study of a Global Pandemic Bhat MA, Rahman S, Rather IA, Banday I, Syed S, Koser H, Kamal MA, Minakshi R, Jan AT. 228



Natural Products: A Rich Source of Antiviral Drug Lead Candidates for the Management of COVID-19 Wijayasinghe YS, Bhansali P, Viola RE, Kamal MA, Poddar NK. 229



E6 and E7 Oncoproteins: Potential Targets of Cervical Cancer Malla R, Kamal MA. 230



mTOR Targeted Cancer Chemoprevention by Flavonoids Ul Islam B, Khan MS, Husain FM, Rehman MT, Zughaibi TA, Abuzenadah AM, Urooj M, Kamal MA, Tabrez S. 231



Cardiac Biomarkers in Stroke, Alzheimer’s Disease, and Other Dementia. Are They of Use? A Brief Overview of Data from Recent Investigations Khan S, Kamal MA. 232



Diabetic Cardiomyopathy: From Mechanism to Management in a Nutshell Khan S, Ahmad SS, Kamal MA. 233



Development of Serological Assays and Seroprevalence Studies of the New Coronavirus 2019 (COVID-19): Reports from Saudi Arabia Alandijany TA, Faizo AA. 244



Lack of Antibodies to SARS-CoV-2 among Blood Donors during COVID-19 Lockdown: A Study from Saudi Arabia Alandijany TA, El-Kafrawy SA, Al-Ghamdi AA, Qashqari FS, Faizo AA, Tolah AM, Hassan AM, Sohrab SS, Hindawi SI, Badawi MA, Azhar EI. 235



Pattern of Respiratory Viruses among Pilgrims during 2019 Hajj Season Who Sought Healthcare Due to Severe Respiratory Symptoms ,Alsayed SM, Alandijany TA, El-Kafrawy SA, Hassan AM, Bajrai LH, Faizo AA, Mulla EA, Aljahdali LS, Alquthami KM, Zumla A, Azhar EI. 236



Test-based de-isolation in COVID-19 immunocompromised patients: Cycle threshold value versus SARS-CoV-2 viral culture Alshukairi AN, Tolah AM, Dada A, Al-Tawfiq JA, Almagharbi RS, Saeedi MF, Al-Hamzi MA, El-Kafrawy SA, Bahaudden HA, El-Saed A, Al- Mozaini MA. 237



Re-infection with a different SARSCoV-2 clade and prolonged viral shedding in a hematopoietic stem cell transplantation patient Alshukairi AN, El-Kafrawy SA, Dada A, Yasir M, Yamani AH, Saeedi MF, Aljohaney A, AlJohani NI, Bahaudden HA, Alam I, Gojobori T. 238



Middle East Respiratory Syndrome Coronavirus Al-Tawfiq JA, Azhar EI, Memish ZA, Zumla A. 239



Molecular Detection of Influenza A and B Viruses in Four Consecutive Influenza Seasons 2015-16 to 2018-19 in a Tertiary Center in Western Saudi Arabia Althaqafi A, Farahat F, Alsaedi A, Alshamrani M, Alsaeed MS, AlhajHussein B, El-Kafrawy SA, Azhar EI. 240



Dissemination of VIM-producing Pseudomonas aeruginosa associated with highrisk clone ST654 in a tertiary and quaternary hospital in Makkah, Saudi Arabia Al-Zahrani IA, Al-Ahmadi BM. 241



Amotosalen and ultraviolet A light treatment efficiently inactivates severe acute respiratory syndrome coronavirus 2 (SARSCoV- 2) in human plasma Azhar EI, Hindawi SI, El‐Kafrawy SA, Hassan AM, Tolah AM, Alandijany TA, Bajrai LH, Damanhouri GA. 242



Understanding the role of potential pathways and its components including hypoxia and immune system in case of oral cancer Bajrai LH, Sohrab SS, Mobashir M, Kamal MA, Rizvi MA, Azhar EI. 243



Gene Expression Profiling of Early Acute Febrile Stage of Dengue Infection and Its Comparative Analysis With Streptococcus pneumoniae Infection Bajrai L, Sohrab SS, Alandijany TA, Mobashir M, Parveen S, Kamal MA, Azhar EI. 244



Structure-Based Identification of Natural Products as SARS-CoV-2 M pro Antagonist from Echinacea angustifolia Using Computational Approaches Bharadwaj S, El-Kafraway SA, Alandijany TA, Bajrai LH, Shah AA, Dubey A, Sahoo AK, Yadava U, Kamal MA, Azhar EI, Kang SG. 245



Analysis of bacterial communities in sponges and coral inhabiting Red Sea, using barcoded 454 pyrosequencing Bibi F, Azhar EI. 246



Assessing the diversity of bacterial communities from marine sponges and their bioactive compounds Bibi F, Naseer MI, Azhar EI. 247



Mechanistic insights into the Japanese encephalitis virus RNA dependent RNA polymerase protein inhibition by bioflavonoids from Azadirachta indica Dwivedi VD, Singh A, El-Kafraway SA, Alandijany TA, Faizo AA, Bajrai LH, Kamal MA, Azhar EI. 248



Immunotherapeutic Efficacy of IgY Antibodies Targeting the Full-Length Spike Protein in an Animal Model of Middle East Respiratory Syndrome Coronavirus Infection El-Kafrawy SA, Abbas AT, Sohrab SS, Tabll AA, Hassan AM, Iwata-Yoshikawa N, Nagata N, Azhar EI. 249



A Direct Method for RT-PCR Detection of SARS-CoV-2 in Clinical Samples El-Kafrawy SA, El-Daly MM, Hassan AM, Kaki RM, Abuzenadah AM, Kamal MA, Azhar EI. 250



A Reliable Indirect ELISA Protocol for Detection of Human Antibodies Directed to SARS-CoV-2 NP Protein Faizo AA, Alandijany TA, Abbas AT, Sohrab SS, El-Kafrawy SA, Tolah AM, Hassan AM, Azhar EI. 251



Prevalence of COVID-19 antibodies among operating room and critical care staff at a tertiary teaching hospital: A cross-sectional study Farsi SH, Alandijany TA, Radwi M, Farsi A, Bahaaziq W, Abushoshah I, El-Kafrawy SA, Alsayed S, Azhar EI, Boker A. 252



Association of tomato yellow leaf curl virus — Oman strain with the leaf curl and yellow mosaic symptoms on papaya and wild poinsettia in Oman Haq QM, Sohrab SS, Brown JK, Al-Harrasi A. 253



Efficient inactivation of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in human apheresis platelet concentrates with amotosalen and ultraviolet A light Hindawi SI, El-Kafrawy SA, Hassan AM, Badawi MA, Bayoumi MM, Almalki AA, Zowawi HM, Tolah AM, Alandijany TA, Abunada Q, Picard- Maureau M. 254



Extended Ecological Restoration of Bacterial Communities in the Godavari River During the COVID-19 Lockdown Period: a Spatiotemporal Meta-analysis Jani K, Bandal J, Shouche Y, Shafi S, Azhar EI, Zumla A, Sharma A. 255



Draft genome of Metabacillus niabensis strain 4T19 T isolated from cotton-waste composts for mushroom cultivation Kangale LJ, Levasseur A, Raoult D, Ghigo E, Fournier PE. 256



Draft Genome Sequence of Comamonas aquatilis Strain LK (= CSUR P6418 = CECT 9772), Isolated from the Planarian Schmidtea mediterranea Kangale LJ, Levasseur A, Raoult D, Ghigo E, Fournier PE. 257



Draft Genome Sequence of Comamonas jiangduensis Strain YW1 T Kangale LJ, Levasseur A, Raoult D, Ghigo E, Fournier PE. 258



Draft Genome Sequence of Vogesella oryzae L3B39 T, Isolated from the Rhizosphere of Saline-Tolerant Pokkali Rice Kangale LJ, Levasseur A, Anani H, Raoult D, Ghigo E, Fournier PE. 259



Chryseobacterium schmidteae sp. nov. a novel bacterial species isolated from planarian Schmidtea mediterranea Kangale LJ, Raoult D, Ghigo E, Fournier PE. 260



Publisher Correction: Chryseobacterium schmidteae sp. nov. a novel bacterial species isolated from planarian Schmidtea mediterranea Kangale LJ, Raoult D, Ghigo E, Fournier PE. 261



Culturomics revealed the bacterial constituents of the microbiota of a 10-yearold laboratory culture of planarian species S. mediterranea Kangale LJ, Raoult D, Fournier PE, Ghigo E. 262



Planarians (Platyhelminthes)—An Emerging Model Organism for Investigating Innate Immune Mechanisms Kangale LJ, Raoult D, Fournier PE, Abnave P, Ghigo E. 263



Draft Genome Sequence of Herminiimonas contaminans Strain CCM 7991 T, a Biopharmaceutical Contaminant Kangale LJ, Zgheib R, Ghigo E, Raoult D, Fournier PE. 264



Prevalence of clinical malaria and household characteristics of patients in tribal districts of Pakistan Karim AM, Yasir M, Ali T, Malik SK, Ullah I, Qureshi NA, Yuanting H, Azhar EI, Jin HJ. 265



Clostridium culturomicium sp. nov. and Clostridium jeddahitimonense sp. nov., novel members of the Clostridium genus isolated from the stool of an obese Saudi Arabian Kieu HT, Garrigou N, Fadlane A, Brechard L, Armstrong N, Decloquement P, Yasir M, Azhar EI, Al-Masaudi SB, Lagier JC, Tidjani Alou M. 266



Zoonotic Tuberculosis - The Changing Landscape Kock R, Michel AL, Yeboah-Manu D, Azhar EI, Torrelles JB, Cadmus SI, Brunton L, Chakaya JM, Marais B, Mboera L, Rahim Z. 267



Alkhumra hemorrhagic fever virus infection Madani TA, Abuelzein ET. 268



Monitoring of the Middle East Respiratory Syndrome Coronavirus Activity in a Secluded Herd of Camels Kept Under Field Conditions Madani TA, Abuelzein ET, Hussien HS, Bashri MA, Hassan AM, Azhar EI. 269



Gemella massiliensis sp. nov., a new bacterium isolated from the human sputum Mbogning Fonkou MD, Lo CI, Mekhalif Z, Bilen M, Tomei E, Kuete Yimagou E, Dubourg G, Raoult D, Fenollar F, Fournier PE. 270



Discovery of Zafirlukast as a novel SARS-CoV-2 helicase inhibitor using in silico modelling and a FRET-based assay Mehyar N, Mashhour A, Islam I, Alhadrami HA, Tolah AM, Alghanem B, Alkhaldi S, Somaie BA, Al Ghobain M, Alobaida Y, Alaskar AS. 271



Analysis of Microbial Communities and Pathogen Detection in Domestic Sewage Using Metagenomic Sequencing Yasir M. 272



Emergence of new SARS-CoV-2 Variant of Concern Omicron (B.1.1.529) - highlights Africa’s research capabilities, but exposes major knowledge gaps, inequities of vaccine distribution, inadequacies in global COVID-19 response and control efforts Petersen E, Ntoumi F, Hui DS, Abubakar A, Kramer LD, Obiero C, Tambyah PA, Blumberg L, Yapi R, Al-Abri S, Pinto TD. 273



Full-genome sequencing and analysis of DENV-3 serotype isolated from Yemen Sohrab SS, Madani TA, El-Kafrawy SA, Al-Bar HM, Farraj SA, Uthman NA, Hassan AM, Bajrai LH, Azhar EI. 274



Natural Products Homoharringtonine and Emetine Alkaloids as SARS-CoV-2 Treatment Options Sohrab SS, Suhail M, Kamal MA, Azhar EI. 275



In Silico Prediction and Designing of Potential siRNAs to be used as Antivirals Against SARS-CoV-2 Sohrab SS, Aly El-Kafrawy S, Abbas AT, Bajrai LH, Azhar EI. 276



Evaluation of a Pseudovirus Neutralization Assay for SARS-CoV-2 and Correlation with Live Virus-Based Micro Neutralization Assay Tolah AM, Sohrab SS, Tolah KM, Hassan AM, El- Kafrawy SA, Azhar EI. 277



Computational and In Vitro Experimental Investigations Reveal Anti-Viral Activity of Licorice and Glycyrrhizin against Severe Acute Respiratory Syndrome Coronavirus 2 Tolah AM, Altayeb LM, Alandijany TA, Dwivedi VD, El-Kafrawy SA, Azhar EI. 278



Lagierella massiliensis gen. nov., sp. nov., Isolated from a Stool Sample Traore SI, Lo CI, Bilen M, Raoult D, Fenollar F, Fournier PE. 279



16S amplicon sequencing of microbial communities in enriched and non-enriched sediments of non-volcanic hot spring with temperature gradients Yasir M, Qureshi AK, Azhar EI. 280



Draft genome sequence of colistin-resistant and extended-spectrum β-lactamase (ESBL)- producing multidrug-resistant Escherichia coli isolated from poultry meat Yasir M, Qureshi AK, Kensarah EA, Bibi F, Al- Zahrani IA, Abd El Ghany M, Azhar EI. 281



Lack of Zika Virus and Other Recognized Flaviviruses among the Mosquito Vectors during and Post the Hajj Mass Gathering Yezli S, Yasir M, Yassin Y, Almazrua A, Al-Subhi T, Othman N, Omar A, Abdoon A, Elamin Y, Abuzaid A, Bafaraj T. 282



Neglectibacter timonensis gen. nov., sp. nov. and Scatolibacter rhodanostii gen. nov., sp. nov., two anaerobic bacteria isolated from human stool samples Zgheib R, Ibrahim A, Anani H, Ndongo S, Bilen M, Armstrong N, Richez M, Raoult D, Fournier PE. 283



New human-associated species of the family Atopobiaceae and proposal to reclassify members of the genus Olsenella Zgheib R, Anani H, Meng MM, Mailhe M, Ricaboni D, Morand A, Caputo A, Traore SI, Fontanini A, Armstrong N, Raoult D. 284



Bacterial diversity and the antimicrobial resistome in the southwestern highlands of Saudi Arabia Yasir M, Khan R, Ullah R, Bibi F, Khan I, Karim AM, Al-Ghamdi AK, Azhar EI. 285



Insight to SARS-CoV-2 Vaccines Based on Virus Structure and Properties Basingab F S H, Zaher K S A. 286



Seroprevalence of neutralizing antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among healthcare workers in Makkah, Saudi Arabia Ahmed WA, Dada A, Alshukairi AN, Sohrab SS, Faizo AA, Tolah AM, El-Kafrawy SA, Bajrai LH, Moalim HM, Aly MH, Aboelazm AF. 287



Allergic acute coronary syndrome: Amoxicillin/clavulanic acid intake Lucas FR, Gigante J, Harakeh S, Vieira P. 288




آخر تحديث
9/11/2024 9:49:36 AM